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World Community Grid Forums
Category: Support
Forum: Suggestions / Feedback
Thread: WCG and Pandemic-Related Projects |
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Thread Status: Active Total posts in this thread: 120
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Falconet
Master Cruncher Portugal Joined: Mar 9, 2009 Post Count: 3294 Status: Offline Project Badges: 
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nasher
Veteran Cruncher USA Joined: Dec 2, 2005 Post Count: 1422 Status: Offline Project Badges: 
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looking forward to this as well
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2384 Status: Offline Project Badges: 
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A deliberative, controlled scientific process is necessary to prevent unforeseen unwanted consequences, such as Hoskins effects. Thanks for the excellent article on Hoskins Effect.http://en.wikipedia.org/wiki/Hoskins%20effect I've been thinking that if the antigen used in vaccination were the conformational form of the Spike protein ACE2 binding epitope that it would be less likely to mutate away from the initial IgG response. If the B cells produced neutralizing IgGs they may offer longer lasting immunity. Problem may that in using peptides or proteins representing the ACE2 binding site the antigen presenting cells (APCs) display such a short peptide (MHC-II presents 13-18 amino acids & MHC-I only 8-10 aa) it could neutralize by blocking the binding epitope but not actually bind that epitope itself. I know, that was clear as mud. I haven't kept up but I see Moderna is conducting a human clinical trial of its mRNA vaccine in Seattle. https://www.washingtonpost.com/outlook/2020/0...-vaccine-trial-volunteer/ Wish I could join. Tried finding a trial in my town but to no avail: https://clinicaltrials.gov/ct2/results?cond=C...mp;rslt=&Search=Apply   ...KRI please cancel all shadow-banning[Edit 3 times, last edit by Aurum420 at Apr 9, 2020 2:42:25 AM] |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2384 Status: Offline Project Badges:
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---------------------------------------- ...KRI please cancel all shadow-banning[Edit 4 times, last edit by Aurum420 at Apr 12, 2020 2:37:05 PM] |
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Falconet
Master Cruncher Portugal Joined: Mar 9, 2009 Post Count: 3294 Status: Offline Project Badges:
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Different studies have shown the SARS-CoV-2 spike protein changes conformation to allow binding to human ACE2 receptor proteins. Will this project use the fusion conformation or a dynamic model??? Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Hey Aurum, that question may be better suited for the Science thread as the admins seem more attentive over there. AMD Ryzen 5 1600AF 6C/12T 3.2 GHz - 85W AMD Ryzen 5 2500U 4C/8T 2.0 GHz - 28W AMD Ryzen 7 7730U 8C/16T 3.0 GHz |
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_heinz
Cruncher Joined: Apr 5, 2020 Post Count: 10 Status: Offline Project Badges:
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I decided to support Cancer and Microbiome meanwhile till Covid19 project is starting. today I got the Silver badge for Cancer Marker.
regards to all crunchers _heinz |
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BladeD
Ace Cruncher USA Joined: Nov 17, 2004 Post Count: 28976 Status: Offline Project Badges: 
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I decided to support Cancer and Microbiome meanwhile till Covid19 project is starting. today I got the Silver badge for Cancer Marker. regards to all crunchers _heinz Of course, there's another on-going Cancer project, Smash Childhood Cancer.  |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: 
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Rosetta@Home is currently running some WUs to help with modeling coronavirus protein. Their WUs are mixed up so I don't know which one is exactly for the coronavirus research. However, I think their purpose is to solve protein folding works from Fold.it . So I guess every WU helps. I'm only dedicating my laptop to Rosetta 'cause there's no job for Android, They had many tasks with "foldit" in their names, but I think all of those are finished now. These were for testing proteins designed by the Fold.it project to get more information on how well they bind to the virus. Now, most of their tasks relevant to the virus have "COVID-19" in their names instead. Their tasks with names beginning with "rb_" are submitted in such a way that their names say little if anything about whether they are related to the virus or not. Their tasks for Android are now called tasks for mobile devices, since they are now able to run on some mobile devices that don't use Android. There often are some, but the demand for them is so high that they tend to run out of them within hours. |
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Dataman
Ace Cruncher Joined: Nov 16, 2004 Post Count: 4865 Status: Offline Project Badges:
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FYI
----------------------------------------Scripts Research, La Jolla CA, 04/01/20: https://www.scripps.edu/news-and-events/press...penPandemics-covid19.html   |
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