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Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Dear all,

We arrived to the launch of HCMD2. The World Community Grid team estimates that the projectwill start in mid-April, 2009. We ultimated everything from our side, MAXDo is in the hands of WCG and the work units are on their way.

HCMD2 will study cross docking of 2246 human protein structures. In total we shall dock 2 466 753 pairs of proteins among the 2246x2246 possible
ones. This means that 913 627 781 945 docking initial positions should be computed by a full cross-docking. By using JET (which predicts protein-protein interfaces), we can reduce the docking space of 87%, that is we shall have only 118 771 611 652 conformations to be analyzed by MAXDo. This makes the computation feasible on WCG! THANKS to you!!

The set of proteins we shall dock contains all proteins known to have a role in muscular dystrophy (MD). In the set, the vast majority of other proteins are potential targets of the MD subset and in the project we shall evaluate the potential interactions between them.

You can find information on the work done in these last months at http://www.ihes.fr/%7Ecarbone/HCMDproject.htm

Looking forward to work with you again very soon.

My best regards,

Alessandra


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Chers tous,

Nous sommes arrivés au moment du lancement de la deuxième phase du projet Help Cure Muscular Dystrophy (HCMD2). La World Community Grid (WCG) estime que le projet débutera mi-avril 2009. Nous avons, de notre côté, terminé tout ce que l'on souhaitait et MAXDo est dans les mains de la WCG. Les unités de calcul seront délivrées très bientôt.

HCMD2 étudiera, par cross docking, 2246 structures protéiques chez l'homme. Au total, nous avons à "docker" 2246x2246 interactions possibles. Cela signifie que 913 627 781 945 positions initiales de docking devraient être calculées par un cross-docking complet. Avec JET (qui prédit les interfaces protéine-protéine), nous allons réduire l'espace de docking de 87%, c'est-à-dire que MAXDo aura seulement 118 771 611 652 conformations à analyser. Cela rend le calcul faisable sur la WCG! Nous vous remercions par avance pour le temps de calcul que vos machines lui dédieront!!

L'ensemble des 2246 protéines qui seront dockées contient toutes les protéines connues pour jouer un rôle dans les maladies neuromusculaires (MN). Dans l'ensemble complet, la vaste majorité des autres protéines sont des cibles potentielles de l'ensemble des MN et, dans le projet, nous allons évaluer les interactions potentielles entre elles.

Vous pouvez trouver les informations sur le travail que nous avons conduit ces derniers mois à l'adresse http://www.ihes.fr/%7Ecarbone/HCMDproject.htm

En attendant de travailler avec vous très bientôt de nouveau.

Très cordialement.

Alessandra
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Thank you very much for the update smile
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Thanks for the update! biggrin
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logaritse
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Thank you for this information :)

can wait until HCMD2 available for crunch cool
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Simplicity meet classic
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mwgiii
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Excellent news.

Will the badges be the same or will there be new badges?
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applause Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Thanks for the update. Can't wait to start crunching! drooling Francis
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ALAIN_13013
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Alessandra,

Voici la nouvelle que nous attendions depuis longtemps. Nous sommes heureux que la phase 1 ait amené des résultats, et nous sommes près pour attaquer la seconde Phase.

Cordialement, Alain.
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Bonjour à tous,

Excellente nouvelle, presque deux ans d'attente, mais ne vous inquiètez pas, les troupes sont loin d'être démotivé ! Il va y avoir bousculade pour faire vos calculs !!!
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gb009761
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Yes, this is truly good news - and I'm sure that there'll be plenty of people 'chomping at the bit' to get your WU's on their CPU's wink
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damir1978
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Re: Help Cure Muscular Dystrophy Update on Febuary 24, 20089

Waaaaaw! Super. I can't wait to contribute. biggrin
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