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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
VIH : Une thérapie génique booste les cellules T contre le virus
----------------------------------------"Cet essai de phase I de première thérapie génique personnalisée, menée sur 12 patients séropositifs, ouvre l’espoir de pouvoir contrôler le virus sans besoin de médicaments antirétroviraux, voire de le repousser à des niveaux indétectables. Menée par des chercheurs américains, cette étude, présentée dans le New England Journal of Medicine, propose une toute nouvelle voie de lutte contre l’infection, protéger les cellules T qui vont pouvoir ainsi repousser le virus jusqu’à l’épuiser presque complètement." http://www.santelog.com/news/VIH-sida-VHC/vih...relasuite.htm#lirelasuite HIV : Gene therapy boosts T cells against virus "This phase I trial of gene therapy first custom, conducted on 12 HIV-positive patients, opens the hope of controlling the virus without the need for antiretroviral drugs or to repel to undetectable levels. Conducted by American researchers, the study, presented in the New England Journal of Medicine, offers a new way to fight against the infection, protect T cells that will power and push the virus to deplete almost completely." http://www.uphs.upenn.edu/news/News_Releases/2014/03/june/ http://www.nejm.org/doi/full/10.1056/NEJMoa1300662 French Article http://www.santelog.com/news/VIH-sida-VHC/vih...relasuite.htm#lirelasuite |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
VIH : un deuxième bébé potentiellement soigné
----------------------------------------"L’an dernier, à la même époque, le bruit courait qu’un bébé avait été guéri fonctionnellement du Sida grâce à une prise en charge très précoce après sa naissance. Une annonce qui avait laissé certains chercheurs dans le doute. Mais celui-ci pourrait bien disparaître puisqu’on annonce désormais qu’un second bébé pourrait être dans la même situation. Il est cependant encore trop tôt pour le prouver." http://www.futura-sciences.com/magazines/sant...potentiellement-soigne%5D |
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Rickjb
Veteran Cruncher Australia Joined: Sep 17, 2006 Post Count: 666 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Researchers have disabled the CCR5 gene in the CD4 T cells in samples of patients' blood and then returned the blood to their bloodstream. CCR5 is the major coreceptor for human immunodeficiency virus (HIV). The procedure was found to be safe in the 12 patients in the trial. There is also evidence that the procedure confers significant resistance to HIV infection of the patients' T cells.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV, Tebas P1, Stein D, Tang WW, Frank I, Wang SQ, Lee G, Spratt SK, Surosky RT, Giedlin MA, Nichol G, Holmes MC, Gregory PD, Ando DG, Kalos M, Collman RG, Binder-Scholl G, Plesa G, Hwang WT, Levine BL, June CH, N Engl J Med. 2014 Mar 6;370(10):901-10. doi: 10.1056/NEJMoa1300662. Abstract |
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twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2129 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
This is a little off topic but is related to HIV prevention. There is a new device for women that is designed to not only prevent conception but will also lower if not eliminate the risk of HIV infection.
----------------------------------------Article from Science Codex. The easy-to-use ring delivers controlled doses of tenofovir (a common antiretroviral drug) and levonorgestrel (a contraceptive) for 90 days. The rings are being manufactured now, and the device soon will undergo its first test in women. ![]() ![]() |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
Thanks for the news twilyth & Rickjb
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
Fighting HIV with an eye on ethics
----------------------------------------"Researchers are grappling with serious ethical concerns amid efforts to design and launch studies to test whether “treatment as prevention” can dramatically slash transmission rates." http://news.harvard.edu/gazette/story/2014/03...n=03.11.daily%2520%281%29 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
Sida : les premiers espoirs de la thérapie génique contre le VIH
----------------------------------------"S’il demeure encore impossible avec les connaissances actuelles d’éradiquer à grande échelle le VIH chez les personnes contaminées, des chercheurs viennent de faire un progrès conséquent en développant une technique de thérapie génique capable de ralentir la progression du virus. Certains patients qui en ont bénéficié ont même pu interrompre leurs traitements antirétroviraux pendant trois mois. Il y a donc là une piste à creuser." http://www.futura-sciences.com/magazines/sant...-genique-contre-le-VIH%5D AIDS : early hopes of gene therapy against HIV "Though it is still impossible with current knowledge to eradicate large-scale HIV infected persons, researchers have just made a substantial progress in developing a gene therapy technique that can slow the progression of the virus. Some patients who have benefited even have interrupted their antiretroviral treatment for three months. There is therefore a track to dig." http://www.nejm.org/doi/full/10.1056/NEJMoa1300662 French Article http://www.futura-sciences.com/magazines/sant...-genique-contre-le-VIH%5D |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Vaginal gel protects 5 out of 6 monkeys from HIV even when administered 3 hours AFTER sex!
http://stm.sciencemag.org/content/6/227/227ra35 [...] gel containing the strand transfer inhibitor L-870812 protected two of three macaques when applied 30 min before SHIV challenge. We next evaluated the efficacy of 1% raltegravir gel and demonstrated its ability to protect macaques when applied 3 hours after SHIV exposure (five of six protected; P < 0.05, Fisher’s exact test). Breakthrough infections showed no evidence of drug resistance in plasma or vaginal secretions despite continued gel dosing after infection. We documented rapid vaginal absorption reflecting a short pharmacological lag time and noted that vaginal, but not plasma, virus load was substantially reduced in the breakthrough infection after raltegravir gel treatment. We provide a proof of concept that topically applied integrase inhibitors protect against vaginal SHIV infection when administered shortly before or 3 hours after virus exposure. |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
Thanks Papa3
----------------------------------------![]() For the french people ![]() VIH : un gel vaginal qui protège de l'infection après le rapport sexuel "Un gel microbicide appliqué jusqu'à trois heures après un rapport sexuel est en mesure de bloquer l'infection par le virus du sida." http://www.sciencesetavenir.fr/sante/20140313...apport-sexuel#xtor=EPR-6-[ActuSciences17h]-20140313 ---------------------------------------- [Edit 1 times, last edit by [CSF] Thomas Dupont at Mar 14, 2014 9:39:18 AM] |
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Aqua1986
Cruncher Portugal Joined: Aug 18, 2006 Post Count: 17 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
For the first time, an allosteric interaction (that is, a regulation mechanism whereby enzymes can be activated or de-activated) between a protein, which forms part of the sheath of the Human Immunodeficiency Virus (HIV) and the antibody 2F5 (FAB), a potent virus neutralizer has been discovered. This important scientific breakthrough could help specialists to understand the mechanisms behind generating immune responses and help towards the design of future vaccines against the HIV virus.
http://www.sciencedaily.com/releases/2014/03/140317084645.htm |
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