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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: Interesting news articles about AIDS |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: 
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http://www.bloomberg.com/news/2014-07-22/aids...ug-rouses-hidden-hiv.html
Researchers from Aarhus University gave the medicine romidepsin to six HIV-infected people in an effort to rouse the virus from the so-called reservoirs where it sleeps. It worked: Infusions of the drug woke the virus up and caused it to start reproducing, a step that may allow the immune system to clear it ... Bionor Pharma ASA (BIONOR), based in Oslo, is studying romidepsin as part of a “kick-and-kill” approach to curing HIV in which romidepsin kicks HIV out of hiding before another drug called Vacc-4x would prompt the immune system to kill it. ... Romidepsin was used at a third of the normal cancer dosing, he said. Side effects were consistent with those known to occur with romidepsin and others in a class of compounds that interfere with the function of the enzyme histone deacetylase. No severe toxicity was observed and no dose reductions were necessary ... patients received three infusions of romidepsin, sold by Celgene Corp. as Istodax, over 14 days. The drug increased virus production in HIV-infected cells by 2.1 to 3.9 times more than normal, and increased the amount of virus to measurable levels in the blood of five patients, a sign that the “kick” part of the ["kick & kill"] strategy is working. Because the amount of HIV that sleeps in viral reservoirs isn’t known, the researchers have no way of knowing how much of the latent virus was flushed out by the drug ... |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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http://www.dailymail.co.uk/sciencetech/articl...virus-human-DNA-time.html
22 July 2014 - Scientists 'delete' HIV virus from human DNA for the first time Process could also be a cure for other latent infections, researchers say Researchers based the two-part HIV-1 editor on a system that evolved as a bacterial defence mechanism to protect against infection. When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and remove the HIV-1 DNA. Dr Khalili's lab engineered a 20-nucleotide strand of gRNA to target the HIV-1 DNA and paired it with a DNA-sniping enzyme called Cas9 and used to edit the human genome. From there, the cell's gene repair machinery takes over, soldering the loose ends of the genome back together – resulting in virus-free cells. |
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Rickjb
Veteran Cruncher Australia Joined: Sep 17, 2006 Post Count: 666 Status: Offline Project Badges: 
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The International AIDS Society (IAS) 2014 annual conference in Melbourne, Australia is currently underway, following the tragic loss of 6 of its delegates in the crash of Malaysian Airlines Flight MH17 in Ukraine. A number of interesting speeches and research papers have been and will be presented there. I'll leave it to others to post summaries here.
----------------------------------------The conference's website is at http://aids2014.org/ We seem to have missed an opportunity to get an advertisement for FAAH on their home page. [Edit 1 times, last edit by Rickjb at Jul 23, 2014 6:04:25 AM] |
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l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: 
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Regarding the AIDS conference, here's a panel discussion from Australian ABC radio. Note the "show transcript" button.
http://www.abc.net.au/radionational/programs/...ence-in-melbourne/5607072 |
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Michael2901
Veteran Cruncher Joined: Feb 6, 2009 Post Count: 586 Status: Offline Project Badges: 
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http://www.ncbi.nlm.nih.gov/pubmed/23922365
J Infect Dis. 2013 Dec 15;208(12):2085-94. doi: 10.1093/infdis/jit395. Epub 2013 Aug 6. Targeting of the purine biosynthesis host cell pathway enhances the activity of tenofovir against sensitive and drug-resistant HIV-1. Heredia A1, Davis CE, Reitz MS, Le NM, Wainberg MA, Foulke JS, Wang LX, Redfield RR. Abstract BACKGROUND: Targeting host-cell pathways to increase the potency of nucleoside/nucleotide analog reverse transcriptase inhibitors (NRTIs) is an important strategy for clinical investigation. Resveratrol is a natural product that inhibits cellular ribonucleotide reductase, prolonging the S phase of the cell cycle and preferentially lowering dATP levels. METHODS: We performed in vitro evaluation of resveratrol on the antiviral activity of adenosine analog tenofovir (TFV) against sensitive and drug-resistant human immunodeficiency virus type 1 (HIV-1), from subtypes B and C, in primary cells. RESULTS: Resveratrol enhanced the antiviral activity of TFV by up to 10-fold and restored susceptibility of TFV-resistant viruses. Resveratrol prevented wild-type HIV-1 from developing phenotypic resistance to TFV. Notably, resveratrol enhanced TFV activity against sensitive and resistant HIV-1 from both subtypes B and C. CONCLUSIONS: Prolonged wide-scale use of thymidine analogs in the setting of viral failure has limited the efficacy of second-line NRTI-based regimens in Africa. Moreover, the extensive use of ddI and d4T has led to high frequencies of the K65R mutation, further compromising TFV efficacy. In light of increasing resistance to commonly used NRTIs in global HIV treatment programs, targeting nucleoside biosynthesis with resveratrol, or derivatives with improved bioavailabilities, is a potential strategy to maintain, enhance, and restore susceptibility of commonly used NRTIs. KEYWORDS: HIV-1; NRTI; antiretrovirals; drug resistance; resveratrol; subtype C; tenofovir PMID: 23922365 [PubMed - indexed for MEDLINE] PMCID: PMC3836462 [Available on 2014/12/15] |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges:
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People With HIV Less Likely to Develop Multiple Sclerosis
"...people with HIV seemed to have a 60 percent less chance of developing MS than those who did not have HIV. Also, the longer a person has had HIV, the less likely they were to develop MS...." http://www.hivplusmag.com/research/2014/08/08...evelop-multiple-sclerosis |
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l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges:
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"...people with HIV seemed to have a 60 percent less chance of developing MS than those who did not have HIV. Also, the longer a person has had HIV, the less likely they were to develop MS...." " I have some good news and some bad news. You're 60% less likely to get MS" Wow, talk about mixed emotions. |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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http://www.bioresearchonline.com/doc/research...atc~c=771+s=773+r=001+l=a
In an unexpected discovery, scientists at Missouri University have found that proteins that promote the entry of viruses like HIV and Ebola into host cells also possess the ability to block the release of these diseases... Gordon Freeman, professor at Harvard Medical School, has analyzed the findings at MU and reports, “The study shows that TIM proteins keep viral particles from being released by the infected cell and instead keep them tethered to the cell surface…We may be able to use this insight to slow the production of these viruses.” |
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littlepeaks
Veteran Cruncher USA Joined: Apr 28, 2007 Post Count: 748 Status: Offline Project Badges: 
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Here's an interesting article from Chemical and Engineering News, describing some of the background, and where we are now in one area of HIV research.
It also gives a good background of some of the methods and obstacles of drug development. Aiming For HIV’s Weak Spot Scientists seek ways to block the virus before it can infect a single cell. |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges:
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"...people with HIV seemed to have a 60 percent less chance of developing MS than those who did not have HIV. Also, the longer a person has had HIV, the less likely they were to develop MS...." " I have some good news and some bad news. You're 60% less likely to get MS" Wow, talk about mixed emotions. I'm sorry not finding in the article your remarks. I guess you've written it, by yourself, didn't you, I_mckeon? |
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