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Jim1348
Veteran Cruncher USA Joined: Jul 13, 2009 Post Count: 1066 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Aurum420,
----------------------------------------Thank you. Those are wonderful illustrations, and as clear (i.e., detailed) an explanation as I can understand in the SA article. It shows what a few billion years of evolution can do for you. [Edit 1 times, last edit by Jim1348 at Jun 28, 2020 4:55:50 PM] |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
[edit]
Also look at Figure 6 to see what a major challenge we're up against: https://www.biorxiv.org/content/10.1101/2020.02.20.957472v1.full.pdf This appears to show that the glycans shielding the virus are built from mannose. Question: Does all of this mannose come from the diet, or is it built in the body from something else? If all of it comes from the diet, would altering the diet so that it produces less mannose after digestion help control both this virus and the others mentioned? If not, does this make the various protein sites where the glycans bind a good target for binding something to block glycan attachment? |
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smeyer55
Senior Cruncher Joined: Feb 15, 2009 Post Count: 303 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
From Wikipedia
Mannose is not an essential nutrient; it can be produced in the human body from glucose, or converted into glucose. |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2387 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I get the drift of your questions as being does altering glycosylation offer any therapeutic value in fighting Covid-19? I doubt it since it's so integral to so many normal cellular process from the springiness of our cartilage to intercellular signalling to forming IgA & IgG antibodies.
----------------------------------------"Glycosylation is a common modification of proteins and lipids that involves non-templated dynamic and complex processes. Glycans have multiple crucial roles in cellular responses to environmental stimuli as well as cellular growth and differentiation; specific changes in glycan composition are directly linked to many diseases." Take a look at Figures 1-7: https://www.nature.com/articles/s41581-019-0129-4 Take a look at the Metabolism biochemical pathway diagram on the mannose page: https://en.wikipedia.org/wiki/Mannose Everything ending in -ase is an enzyme and -ose is a sugar. If one were deficient in mannose your body would up-regulate certain pathways to make mannose from glucose, fructose, galactose or glycogen (stored in fat cells). Problem I'm worried about is that if a drug is developed in silico for the bare viral protein but in the wild it was covered in wavy sugary hairs that hid its binding site then it would be useless. The scientists at Scripps are among the best in the world and they'll plan for this. It significantly reduces available target sites. ![]() ![]() [Edit 2 times, last edit by Aurum420 at Jun 29, 2020 5:56:35 PM] |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I found partial answers to my questions.
Human metabolism can turn glucose into mannose; therefore diet is not the only source of mannose except in some people with genetic disorders blocking this conversion. Human metabolism uses mannose for various purpose, so permanently eliminating it is not a good idea. It is normally NOT used as an energy source. Too high a level of mannose can be fatal. High levels of mannose are often seen in those with diabetes; this MIGHT be why COVID-19 is often more severe in those with diabetes. MANNOSE METABOLISM: MORE THAN MEETS THE EYE https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252654/ |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
The places where proteins or glycans connect to cell walls are called GPI anchors.
Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology: Introduction to a Thematic Review Series https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689333/ Human metabolism uses some on human cell walls, so elimination all of them is not a good idea. A GPI anchor contains mannose and a phospholipid. |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
The SARS-CoV2 virus which causes COVID-19 DOES use glycans, built mostly from mannose, for shielding from the immune system.
Site-specific glycan analysis of the SARS-CoV-2 spike https://science.sciencemag.org/content/early/2020/05/01/science.abb9983 |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
World's dominant strain of coronavirus 'is 10 TIMES more infectious than the one that jumped to humans in China' because it mutated so its vital spike protein doesn't snap as often in the body, scientists say
A mutated version of the coronavirus that has gripped Europe and the West is more infectious because it doesn't break as often inside the body, a study has found. Researchers at The Scripps Research Institute in Florida say the 'spike protein' that the virus uses to attach to cells in the airways has adapted since January. http://a.msn.com/05/en-us/BB167e7l?ocid=se ![]() |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
New journal will vet Covid-19 preprints, calling out misinformation and highlighting credible research
The wild, wild west of Covid-19 preprints is about to get a new sheriff. On Monday, the MIT Press is announcing the launch of an open assess journal Rapid Reviews: Covid-19 that will publish reviews of preprints related to Covid-19, in an effort to quickly and authoritatively call out misinformation as well as highlight important, credible research. https://www.statnews.com/2020/06/29/new-journal-vet-covid-19-preprints/ ![]() |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Study finds hydroxychloroquine helped coronavirus patients survive better
A surprising new study found that the controversial antimalarial drug hydroxychloroquine helped patients survive better in the hospital. http://a.msn.com/05/en-us/BB16hifu?ocid=se ![]() |
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