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World Community Grid Forums
Category: Active Research
Forum: OpenPandemics - COVID-19 Project
Thread: Covid-19 - Discuss Scientific Papers |
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Thread Status: Active Total posts in this thread: 80
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges: 
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Development of an openEHR Template for COVID-19 Based Clinical Guidelines
This study has developed the openEHR template for COVID-19 based on the latest guideline from China using openEHR modeling methodology. It represented the capability of the methodology for rapidly modeling and sharing knowledge through reusing the existing archetypes, which is especially useful in a new and fast-changing area such as with COVID-19. https://www.jmir.org/2020/6/e20239/  |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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Mutated coronavirus shows significant boost in infectivity - Scripps Research
COVID-19- causing variant taking over in the United States and Europe now carries more functional, cell-binding spikes. A tiny genetic mutation in the SARS coronavirus 2 variant circulating throughout Europe and the United States significantly increases the virus' ability to infect cells, lab experiments performed at Scripps Research show. The new study by researchers at Scripps Research, based in Florida has not yet been peer reviewed, shows that the mutation appears to change the biological function of the virus, experts say. https://www.scripps.edu/news-and-events/press...virus-spike-mutation.html |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2386 Status: Offline Project Badges: 
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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
----------------------------------------https://science.sciencemag.org/content/early/2020/06/15/science.abc7520 https://www.scripps.edu/news-and-events/press...rton-covid19antibody.html   ...KRI please cancel all shadow-banning |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2386 Status: Offline Project Badges:
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The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
----------------------------------------https://www.scripps.edu/_files/pdfs/news-and-...rotein%20reduces%20S1.pdf Press release: https://www.scripps.edu/news-and-events/press...virus-spike-mutation.html ...KRI please cancel all shadow-banning[Edit 1 times, last edit by Aurum420 at Jun 20, 2020 5:06:58 AM] |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: 
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Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane
https://pubs.acs.org/doi/10.1021/acs.jpcb.0c04553 |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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How the Coronavirus Short-Circuits the Immune System
In a disturbing parallel to H.I.V., the coronavirus can cause a depletion of important immune cells, recent studies show. https://www.nytimes.com/2020/06/26/health/cor...system.html?smid=em-share |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2386 Status: Offline Project Badges:
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Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane You beat me to it. I was going to read it first. These guys posted a video of the glycosylated Spike. All these "thorns" sure restrict the available sites for IgGs or other molecules to bind to S. Hopefully we're modeling glycosylated proteins.https://pubs.acs.org/doi/10.1021/acs.jpcb.0c04553 ...KRI please cancel all shadow-banning |
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Jim1348
Veteran Cruncher USA Joined: Jul 13, 2009 Post Count: 1066 Status: Offline Project Badges:
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The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. https://foldingathome.org/2020/06/26/the-sars...phase-separates-with-rna/This is all very interesting. Maybe you can figure out what it means. |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2386 Status: Offline Project Badges:
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Jim1348, That's a very interesting topic. I've been talking to Veronica Falconieri Hays & Jennifer Fairman about their beautiful illustrations of SARS-CoV-2 and how they modeled its nucleocapsid.
----------------------------------------https://www.scientificamerican.com/article/ho...-for-scientific-american/ https://www.scientificamerican.com/interactiv...onavirus/?utm_source=digg She gave me this 2011 reference from SARS research and Figure 10 is very interesting. I've been meaning to post it to suggest that if one could produce covalent linkers to clump M-shorts or M-longs together it could disrupt virion assembly: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486061/ I don't see the full article just the abstract & it turns my brain into a condensate. I see there's several other papers just out on the same topic. More after I do some reading. ...KRI please cancel all shadow-banning |
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Aurum
Master Cruncher The Great Basin Joined: Dec 24, 2017 Post Count: 2386 Status: Offline Project Badges:
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Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane You beat me to it. I was going to read it first. These guys posted a video of the glycosylated Spike. All these "thorns" sure restrict the available sites for IgGs or other molecules to bind to S. Hopefully we're modeling glycosylated proteins.https://pubs.acs.org/doi/10.1021/acs.jpcb.0c04553 Also look at Figure 6 to see what a major challenge we're up against: https://www.biorxiv.org/content/10.1101/2020.02.20.957472v1.full.pdf ...KRI please cancel all shadow-banning[Edit 1 times, last edit by Aurum420 at Jun 28, 2020 3:02:30 PM] |
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