http://www.medicalnewstoday.com/releases/262622.php

"Article Date: 01 Jul 2013

Protein Is Involved With Colon Cancer Cell's Ability To Invade Other Cells


Understanding how the protein km23-1 enables in the spread of colon cancer may lead to new treatments for the disease, according to researchers at Penn State College of Medicine.

Previous research shows that km23-1 is involved in the movement of cancer cells and in the control of specific proteins at the leading edge of moving cells. Kathleen Mulder, professor of biochemistry and molecular biology, who discovered the protein, now says km23-1 is used in the cancer cell's ability to move out of a tumor in the early stages of invasion..."

http://www.medicalnewstoday.com/releases/262652.php

"Article Date: 02 Jul 2013

A Double-Edged Sword: How Oncogenes And Tumor Suppressor Genes Can Contribute To Chromosomal Instability

Cells rely on an intricate network of signaling pathways to govern a number of processes ranging from tissue repair to programmed cell death. De-regulation of signaling pathways is a hallmark of cancer and responsible for driving tumor formation.

Aneuploidy, defined as an abnormal chromosome number, is a distinct feature commonly observed in most solid tumors that arises from errors in cell division during mitosis. While some tumors maintain a stably aneuploid genome, many cancer cells persistently mis-segregate their chromosomes during mitosis, a phenomenon known as chromosomal instability (CIN). CIN is thought to drive the genomic re-shuffling that enables cells to acquire new phenotypes such as drug resistance and is intimately associated with loss of mitotic fidelity..."

http://www.medicalnewstoday.com/articles/262739.php

"Article Date: 02 Jul 2013

Vitamin C Influences Gene Activity In Stem Cells

A study of mouse stem cells reveals that vitamin C may play a role in their health by influencing the switching on and off of genes. The researchers suggest this could have an important effect on the development of mice, humans and other animals, and finding out more about the underlying mechanisms could improve our understanding of in vitro fertilization, cancer and adult stem cells..."

http://www.medicalnewstoday.com/releases/262753.php

"Article Date: 03 Jul 2013

When The Body Turns Traitor And Aids And Abets The Spread Of Cancer

The very system that is meant to protect the body from invasion may be a traitor. These new findings of a study, led by investigators at the Research Institute of the McGill University Health Centre (RI-MUHC), reveal that infection-fighting white blood cells play a role in activating cancer cells and facilitating their spread to secondary tumours. This research, published in the Journal of Clinical Investigation has significant implications for both the diagnosis and treatment of cancer.

"We are the first to identify this entirely new way that cancer spreads," says senior author Dr. Lorenzo Ferri, MUHC director of the Division of Thoracic Surgery and the Upper Gastrointestinal (GI) Cancer Program. "What's equally exciting is medications already exist that are being used for other non-cancer diseases, which may prevent this mechanism of cancer spread or metastasis." According to Dr. Ferri, the next steps are to validate if these medicines will work for the prevention and treatment of cancer metastasis, and then to determine the optimal timing and dosing..."

http://www.medicalnewstoday.com/releases/262844.php

"Article Date: 03 Jul 2013

Study Confirms Adding Chemotherapy To Surgery Improves Survival In Advanced Gastric Cancer

For patients with advanced gastric cancer, treatment with chemotherapy after surgery can reduce the risk of cancer related death by 34% over five years compared to surgery alone, researchers said at the 15th ESMO World Congress in Gastrointestinal Cancer..."