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Re: Interesting news articles about AIDS

7 Mar 2010 BusinessWeek: "HIV Hides Out in Bone Marrow Cell"
http://www.businessweek.com/lifestyle/content/healthday/636732.html
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Re: Interesting news articles about AIDS

http://www.hivvaccineenterprise.org/sites/def...0Brief%20March%202010.pdf

http://www.hivvaccineenterprise.org/content/f...ling-increased-nih-fundin

The benefts of HIV/AIDS research extend far beyond helping
those people at risk for or living with HIV. Investment in AIDS
research has provided scientists worldwide with a model for
combating an array of other diseases and conditions. For
example, AIDS research has led to:
* Promising Experimental Treatments for Cancer
* Potential Benefits for Heart Attack and Stroke Patients
* New Approaches to Treating Hepatitis, Osteoporosis,
Heart Damage, and Influenza
etc.
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Re: Interesting news articles about AIDS

San Francisco Wins $9.5 Million Grant to Develop a New HIV/AIDS Research Center

http://www.californiachronicle.com/articles/view/145190

The AIDS Office will not only renovate new and existing research space to conduct state-of-the-art HIV research, but will also allow the City a broader opportunity to promote collaboration between research units and colleagues worldwide, and create meeting space for community members to guide research efforts.
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Re: Interesting news articles about AIDS

VGTI offering new insights into HIV research

http://www.tcpalm.com/news/2010/mar/07/vgti-o...sights-into-hiv-research/

HIV triggers the gut to release bacteria, which prompt white blood cells to produce a protein called PD-1. Too much PD-1 triggers the production of another protein — IL-10 — and those two proteins, which are known to be present at high levels during HIV infection, work together to shut down disease-fighting T-cells and weaken the entire immune system.

The creation and interaction of these proteins begins to explain why some HIV-infected people have low viral loads but still have major problems in their immune system, Sékaly said.
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Re: Interesting news articles about AIDS

http://www.sciencecodex.com/lightactivated_wa...nto_super_protein_killers

Using a novel light activation technique, Scripps Research Institute scientists have been able to turn molecules with only a modest ability to fight specific proteins into virtual protein destroyers. The new technique, which uses a "warhead" molecule capable of inactivating nearby proteins when triggered by light, could help to accelerate the development of new therapies by providing researchers with a new set of research tools and options. The study was published March 14, 2010 in an advanced, online edition of the journal Nature Chemical Biology. "High-throughput screening can produce a synthetic ligand [peptoid] capable of binding to just about any protein you want," said Thomas Kodadek, a professor in the Department of Chemistry at the Institute's Jupiter, Florida, campus, who led the study. "The problem is, they almost always have modest potency – which makes them less than ideal research tools. By attaching this 'warhead' molecule to a peptoid, we've shown that we can increase that protein-killing potency by a thousand fold without going through an expensive and time-consuming optimization process." [...]
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Papa3
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Re: Interesting news articles about AIDS

http://www.sciencecodex.com/university_of_mic...nhibitor_of_hiv_infection

A potent new inhibitor of HIV, derived from bananas, may open the door to new treatments to prevent sexual transmission of HIV, according to a University of Michigan Medical School study published this week. [...] In laboratory tests, BanLec, the lectin found in bananas, was as potent as two current anti-HIV drugs. Based on the findings published March 19 in the Journal of Biological Chemistry, BanLec may become a less expensive new component of applied vaginal microbicides, researchers say. [...] Some of the most promising compounds for inhibiting vaginal and rectal HIV transmission are agents that block HIV prior to integration into its target cell. The new research describes the complex actions of lectins and their ability to outsmart HIV. [...] The U-M team discovered BanLec, the lectin in bananas, can inhibit HIV infection by binding to the sugar-rich HIV-1 envelope protein, gp120, and blocking its entry to the body. [...] "Lectins can bind to the sugars found on different spots of the HIV-1 envelope, and presumably it will take multiple mutations for the virus to get around them," [...]
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Re: Interesting news articles about AIDS

Establishment of a research consortium to explore the barriers to and potential for eradication of HIV infection.

http://www.amfar.org/lab/grants/default.aspx?id=8358

Each collaboration is funded for a total of up to $300,000 for direct costs plus up to 20 percent for indirect costs. The performance period for collaborations funded under this RFP will be for one year starting May 1, 2010, and may be renewable for subsequent years. Application Deadline: March 25, 2010
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Re: Interesting news articles about AIDS

http://www.sciencecodex.com/acne_drug_prevents_hiv_breakout

Acne drug prevents HIV breakout - In monkeys treated with minocycline, the virus load in the cerebrospinal fluid, the viral RNA in the brain and the severity of central nervous system disease were significantly decreased - "Minocycline reduces the capability of the virus to emerge from resting infected T cells," - minocycline very selectively interrupts certain specific signaling pathways critical for T cell activation. However, the antibiotic doesn't completely obliterate T cells or diminish their ability to respond to other infections or diseases
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Re: Interesting news articles about AIDS

http://abcnews.go.com/Technology/flawless-dia...ry?id=10137275&page=2

How Could Flawless Diamonds Change Future of Medicine?
Immaculate Diamonds Could Produce New Generation of Powerful Lasers

The diamond the Argonne and Brookhaven scientists used wasn't completely flawless, but it was close enough.

"This is a huge milestone in this type of laser research," said Stephen Durbin, a scientist at Purdue University who wrote an accompanying article in Nature Physics about the diamond mirror.

X-ray lasers would take pictures of much smaller things like proteins, drugs or other molecules. To take a picture of these tiny structures, scientists have to carefully and painstakingly grow entire crystals of these molecules. An X-ray laser would eliminate the need for these crystals; a single molecule could take a better picture than anything currently available.
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Re: Interesting news articles about AIDS

http://www.sciencecodex.com/compound_screenin..._development_made_simpler

Dr Jonathan Baell and Dr Georgina Holloway have developed a series of 'filters' that can be used to weed out those molecules likely to come up as false positives when screening a chemical library for compounds that could be useful in drug development.
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