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Category: Completed Research Forum: Smash Childhood Cancer Thread: SCC Project starts a new phase in their quest for curing childhood cancers |
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Thread Status: Active Thread Type: Sticky Thread Total posts in this thread: 70
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Falconet
Master Cruncher Portugal Joined: Mar 9, 2009 Post Count: 3295 Status: Offline Project Badges: |
There were 3 drug docking programs used for the fightAIDS@home project: Autodock, VINA, and BEDAM. The first 2 of these were developed in-house at Scripps, while BEDAM was developed elsewhere. I gather that each gave different results, and in general they gave too many false positives. BEDAM is very CPU-intensive, and was only used for a limited selection of the most promising drug leads from the other 2 programs. Any or all of these could have been used for the earlier phases of SCC, but VINA was the chosen one, probably because it ran fastest. VINA could also have been chosen for Open Pandemics (OPN), but the current, upgraded, verson of Autodock (Autodock4) is being used instead. The upgrade has enabled the program to model covalent bonding, which could not be done by the original Autodock or presumably by VINA. Additionally, a GPU version of Autodock is now in use and this overcomes the disadvantage of Autodock running more slowly than VINA, by a vast margin. Has Autodock4 for CPU and/or GPU been trialled for SCC, and are there any plans to do so? Interesting questions. AMD Ryzen 5 1600AF 6C/12T 3.2 GHz - 85W AMD Ryzen 5 2500U 4C/8T 2.0 GHz - 28W AMD Ryzen 7 7730U 8C/16T 3.0 GHz |
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Mad_Max
Cruncher Russia Joined: Nov 26, 2012 Post Count: 22 Status: Offline Project Badges: |
If you have any comments or questions, please leave them in this thread for us to answer. Thank you for your support, patience and understanding. There is a minor error in your news / announcement: As of December 2020, 48,000 hours of calculations have been donated to the SCC team by WCG volunteers It clearly should be years, not hours. 48 000 hrs is a puny amount of calculations - just little above 5 years of CPU time ( 48000/24/365 = 5,47y) When the project was active on WCG, it was running at pace of several dozen years of CPU time in just one/each calendar day! It is an equivalent of several hundred thousand of CPU cores running 24/7. |
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Cyclops
Senior Cruncher Joined: Jun 13, 2022 Post Count: 295 Status: Offline |
If you have any comments or questions, please leave them in this thread for us to answer. Thank you for your support, patience and understanding. There is a minor error in your news / announcement: As of December 2020, 48,000 hours of calculations have been donated to the SCC team by WCG volunteers It clearly should be years, not hours. 48 000 hrs is a puny amount of calculations - just little above 5 years of CPU time ( 48000/24/365 = 5,47y) When the project was active on WCG, it was running at pace of several dozen years of CPU time in just one/each calendar day! It is an equivalent of several hundred thousand of CPU cores running 24/7. Hi Mad_Max, thanks for catching that, the article been updated to say years as we intended. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Cyclops what a lot of people want to here is when will work units for SCC be ready to be sent out to the people
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Warped@RSA
Senior Cruncher South Africa Joined: Jan 15, 2006 Post Count: 420 Status: Offline Project Badges: |
Is there any news about when these work units will be released for crunching?
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Dave
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Pete Broad
Senior Cruncher Wales Joined: Jan 3, 2007 Post Count: 167 Status: Offline Project Badges: |
There's usually a period of Beta testing for this project before the official launch.
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Hans Sveen
Veteran Cruncher Norge Joined: Feb 18, 2008 Post Count: 803 Status: Offline Project Badges: |
Welcome back SCC!
----------------------------------------Just received my first wu since 12/10/ 2020. This one: SCC1_0004081_MyoD1-A_7911 [Edit 1 times, last edit by Hans Sveen at Apr 21, 2023 5:57:02 AM] |
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bfmorse
Senior Cruncher US Joined: Jul 26, 2009 Post Count: 295 Status: Offline Project Badges: |
Cyclops what a lot of people want to here is when will work units for SCC be ready to be sent out to the people I can’t speak for Cyclops but, I have observed SCC WU’s slowly and quietly released for processing. And ZERO http issues!Thank you for allowing us to contribute! |
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adriverhoef
Master Cruncher The Netherlands Joined: Apr 3, 2009 Post Count: 2104 Status: Recently Active Project Badges: |
[I can’t speak for Cyclops but, I have observed SCC WU’s slowly and quietly released for processing. And ZERO http issues! That's right. So, while OPNG-workunits are easy to get now, let nobody tell you that releasing OPNG-workunits causes HTTP errors. (Speaking for myself, of course, welcoming other opinions.) The last sole HTTP error for me was on 20-Apr-2023 at 11:29:24 UTC and the one before that was on 18-Apr-2023 at 06:55:21 UTC. |
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Grumpy Swede
Master Cruncher Svíþjóð Joined: Apr 10, 2020 Post Count: 2106 Status: Offline Project Badges: |
Very good. I just got my first "new" SCC task, on my slow, Samsung RV-511 Laptop. (at the moment, my only running computer). The price for electricity is more than I'm willing to pay, so I surely do not run my computers 24/7.
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