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[CSF] Thomas Dupont
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News CXXXII

CANCER BUCCAL, l'autre cancer du fumeur

"Un lien plus que significatif entre le tabagisme et l'infection virale responsable des cancers de la bouche et de la gorge vient d’être mis en évidence par ces chercheurs du Johns Hopkins Medicine. Leurs conclusions, présentées dans le JAMA, confirment également la présence majoritaire du papillomavirus de type 16 (HPV16), transmis par le sexe oral, dans 80% de ces cancers de la gorge."

http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite

ORAL CANCER, another smoker's cancer

"That a more significant link between smoking and viral infection responsible for cancers of the mouth and throat has been highlighted by the researchers from Johns Hopkins Medicine. Their findings, reported in JAMA, also confirmed the predominant presence of HPV type 16 (HPV16), transmitted through oral sex, 80% of throat cancers."

http://www.eurekalert.org/pub_releases/2014-10/jhm-rfl100314.php

French Article
http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite
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[CSF] Thomas Dupont
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News CXXXIII

Genomic diversity of individual lung tumors revealed

"The challenge of what scientists call genomic heterogeneity, the presence of many different variations that drive tumor formation, growth and progression, has now been addressed by scientists. The researchers conducted whole exome sequencing on 48 tumor regions from 11 surgically removed localized lung adenocarcinomas, cancers that form in the epithelial tissue that lines the lung. Surgery for these non-small cell lung cancers is potentially curative."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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No news today crying
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[CSF] Thomas Dupont
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News CXXXIV

1- New cancer drug to begin trials in multiple myeloma patients

"A new cancer drug has been developed, which researchers plan to trial in multiple myeloma patients by the end of next year. The researchers report how the drug, known as DTP3, kills myeloma cells in laboratory tests in human cells and mice, without causing any toxic side effects, which is the main problem with most other cancer drugs. The new drug works by stopping a key process that allows cancer cells to multiply."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

2- Bio-inspired 'nano-cocoons' offer targeted drug delivery against cancer cells

"Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News CXXXV

1- Immune cells in liver drive fatty liver disease, liver cancer

"Immune cells that migrate to the liver and interact there with liver tissue cells get activated by metabolic stress (e.g. through lipids of a high fat diet) and drive the development of fatty liver disease, non-alcoholic steatohepatitis and liver cancer. Scientists made this discovery and thus identified the previously unknown mechanism underlying these serious and widespread diseases."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

2- New treatment designed to save more eyes from cancer

"A new technique for treating the eye cancer retinoblastoma has been developed to improve the odds for preventing eye loss, blindness or death in children with advanced forms of the disease. The new procedure is credited saving the eyesight of a 4-year-old girl."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

3- Helping outdoor workers reduce skin cancer risk

"Skin cancer is one of the biggest fears for one in two outdoor workers, and when the boss and staff work together the sun safe message gets through, a study has found."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

4- Discovery of cellular snooze button advances cancer, biofuel research

"The discovery of a cellular snooze button has allowed a team of scientists to potentially improve biofuel production and offer insight on the early stages of cancer."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

5- How metastases develop in the liver

"Most tumors are only fatal if the cancer cells spread in the body and form secondary tumors, known as metastases, in other organs, such as the liver. Scientists have now shown that increased amounts of a particular protein in the liver create favorable conditions for the implantation of cancer cells and thus for the formation of metastases. The researchers have already succeeded in preventing these processes in an animal model."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

6- Factors that may contribute to pancreatic cancer: New insight

"New research provides a better understanding of pancreatic cancer, and may help identify individuals at increased risk. Pancreatic cancer is a stealthy cancer that is usually detected at very late stages and has a 5-year survival rate of less than 5 percent."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

7- Side effects of cancer prevention surgery can be helped with a single-day education program, study finds

"More women are having ovary-removing surgery as a cancer prevention measure, but many are often unaware of sexual or psychological side effects of the procedure. A new study shows a half-day educational program can help successfully deal with these issues by educating women on how to address them."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

8- New target for personalized brain cancer treatment: PTPRZ-MET fusion protein

"A new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors has been identified by researchers. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

9- Treating cancer: Biologists find gene that could stop tumors in their tracks

"A gene in a soil amoeba that can overcompensate for the specific mutations of a similar gene has been found by researchers. In humans, those genetic mutations can often lead to tumor growth. Researchers are now looking for a separate human gene that could overcompensate for mutations in the same way."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News CXXXVI

CANCER du POUMON : Diagnostic trop tardif, très mauvais pronostic

"Ces préoccupations sont toutes britanniques mais riches d’enseignement quel que soit le pays considéré. Cette étude, menée sur de plus de 20.000 dossiers médicaux, montre que faute de détection suffisamment précoce du cancer du poumon au Royaume-Uni, environ un patient sur 3 meurt dans les 90 jours suivant son diagnostic. Ces données viennent d’être publiées dans la revue Thorax."

http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite

LUNG CANCER : Diagnosis too late, very poor prognosis

"These concerns are all British but full of information regardless of the country. The study was conducted on more than 20,000 medical records, shows that the absence of sufficiently early detection of lung cancer in the UK, about one in 3 patients died within 90 days of diagnosis. These data were recently published in the journal Thorax."

http://thorax.bmj.com/content/early/2014/09/1...2014-205692.full.pdf+html

French Article
http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite
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[CSF] Thomas Dupont
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News CXXXVII

1- Personalized cellular therapy achieves complete remission in 90 percent of acute lymphoblastic leukemia patients studied

"Ninety percent of children and adults with acute lymphoblastic leukemia who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, researchers report."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

2- Optimal particle size for anticancer nanomedicines discovered

"Nanomedicines consisting of nanoparticles for targeted drug delivery to specific tissues and cells offer new solutions for cancer diagnosis and therapy. In a recent study, researchers systematically evaluated the size-dependent biological profiles of three monodisperse drug-silica nanoconjugates to determine the optimum particle size for tissue penetration and tumor inhibition."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

3- Subsidies help breast cancer patients adhere to hormone therapy

"A federal prescription-subsidy program for low-income women on Medicare significantly improved their adherence to hormone therapy to prevent the recurrence of breast cancer after surgery, an investigator reports."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

4- Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer

"SIRT6 -— a protein that inhibits the growth of liver and colon cancers -— can promote the development of skin cancers by turning on an enzyme that increases inflammation, proliferation and survival of sun-damaged skin cells. This suggests that SIRT6 could provide a useful target for cancer prevention."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

5- Prostate cancer's penchant for copper may be a fatal flaw

"Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness, scientists report. Researchers have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News CXXXVIII

1- Modeling tumor dormancy: What makes a tumor switch from dormant to malignant?

"A new computational model may help illuminate the conditions surrounding tumor dormancy and the switch to a malignant state. The so-called cellular automaton model simulated various scenarios of tumor growth leading to tumor suppression, dormancy or proliferation."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

2- Personalized ovarian cancer vaccines developed

"New genomic analysis techniques were used by researchers to identify specific protein sequences, called epitopes, that the immune system can use to identify cancer cells. Their key insight was that the most effective epitopes to include in a personalized vaccine are not those that react most strongly with the immune system, but rather the epitopes that differ most from the host's normal tissue."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

3- Human cancer prognosis related to newly identified immune cell

"A newly discovered population of immune cells in tumors is associated with less severe cancer outcomes in humans, and may have therapeutic potential, according to a new study of 3,600 human tumors of 12 types, as well as mouse experiments."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

4- Cryptic clues drive new theory of bowel cancer development

"Researchers have challenged conventional thinking on how the bowel lining develops and, in the process, suggested a new mechanism for how bowel cancer starts. The researchers produced evidence that stem cells are responsible for maintaining and regenerating the 'crypts' that are a feature of the bowel lining, and believe these stem cells are involved in bowel cancer development, a controversial finding as scientists are still divided on the stem cells' existence."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

5- Ovarian cancer: New test can help doctors choose best treatment

"A new test to help doctors diagnose ovarian tumors and choose the most appropriate treatment has been devised by researchers. Successful treatment depends in part on accurately identifying the type of tumor, but this can be difficult. The new test can discriminate between benign and malignant tumors, and identify different types of malignant tumor, with a high level of accuracy."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

6- Adenocarcinoma: UK tops global league table for gullet cancer in men

"The UK tops the international league table for a type of gullet (oesophageal) cancer, known as adenocarcinoma, in men, reveals a comprehensive estimate of the total number of new cases around the globe in 2012. Worldwide, men are around four times as likely as women to develop the disease, the findings show."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

7- Use of intensive medical services for ovarian cancer patients at end of life increases despite rise in use of hospice

"As more patients choose to spend their final days and weeks in hospice care rather than a hospital, the hope is the use of intensive and costly hospital services would decline. A new study shows that for one group of terminally ill cancer patients, that is not what is happening. Authors suggest that many patients received aggressive treatments while in the hospital, and resorted to hospice care as an "add-on" when those treatments fail, the authors write."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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No news today crying
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[CSF] Thomas Dupont
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News CXXXIX

1- Patients treated with radiation therapy who have tumors in left breast have comparable overall survival to those with tumors in right breast

"Tumor laterality (left-side vs. right-side) does not impact overall survival in breast cancer patients treated with breast-conserving surgery and adjuvant external beam radiation therapy, according to a study."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

2- Selenium effective treatment against breast cancer, study suggests

"Selenium, when attached to a monoclonal antibody presently used to treat breast cancer, has shown greater success in destroying cancer cells in a patient who has developed resistance to the chemotherapy, research demonstrates. Almost a quarter of a million people were diagnosed with breast cancer this year, while another 3 million are living with the disease."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

3- Biomarkers uPA/PAI-1 in breast cancer: Benefit, harm of test unclear

"Since studies are lacking, it remains unclear whether certain patients have a benefit if the decision for or against adjuvant chemotherapy is based on the concentration of uPA and PAI-1, a new report states."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

4- Advances in creating treatment for common childhood blood cancer

"A new drug in development may offer first alternative to standard chemotherapy for T-Cell Acute Lymphoblastic Leukemia, scientists report. An estimated quarter of the 500 U.S. adolescents and young adults diagnosed each year with this aggressive disease fail to respond to standard chemotherapy drugs that target cancer cells."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

5- Earlier unknown molecular-level mechanism may contribute to growth rate of breast cancer

"A previously unknown molecular-level mechanism that may partly explain the increased growth of cancer cells has been discovered by researchers. The study showed that high levels of miRNA-378a-5p molecule cause cell division anomalies. This renders the number of chromosomes in cancer cells abnormal, which is known to promote growth and the spread of cancer."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

6- Genetic variant protects some Latina women from breast cancer

"A genetic variant common in Latina women protects against breast cancer, an international research collaboration has found. The variant, a difference in just one of the three billion "letters" in the human genome known as a single-nucleotide polymorphism (SNP), originates from indigenous Americans and confers significant protection from breast cancer, particularly the more aggressive estrogen receptor-negative forms of the disease, which generally have a worse prognosis."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29

7- 3-D printed facial prosthesis offers new hope for eye cancer patients following surgery

"A fast and inexpensive way to make facial prostheses for eye cancer patients has been developed using facial scanning software and 3-D printing, according to researchers. Their novel process can create more affordable prosthetics for any patients who have hollow sockets resulting from eye surgery following cancer or congenital deformities."

http://www.sciencedaily.com/releases/2014/10/...ily%3A+Top+Health+News%29
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