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yojimbo197
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Re: Trojan Horse Cancer Killer

Yes, HIF's are transcription factors. There are chaperonins that are upregulated/highly expressed with heat shock. But if memory serves me, there are other proteins besides chaperonins that get upregulated during heat shock.
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[Dec 23, 2012 11:00:09 PM]   Link   Report threatening or abusive post: please login first  Go to top 
twilyth
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Re: Trojan Horse Cancer Killer

I just meant that both are involved in regulating protein folding. I would imagine that heat shock proteins function mainly to stabilize the 3D structure of proteins that are already folded whereas chaperonins provide the environment needed for a protein to assume its functional 3D form once synthesized.

IDK. I don't really follow this stuff that closely but it's pretty damn cool.

Thanks for the information. Cheers!
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[Dec 23, 2012 11:04:12 PM]   Link   Report threatening or abusive post: please login first  Go to top 
yojimbo197
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Re: Trojan Horse Cancer Killer

Yeah I don't think you are understanding what I"m saying. Heat shock proteins were initially identified as proteins of a specific molecular weight(X kDaltons) that were significantly upregulated after heat shocking cells. Investigators then indentified the DNA and protein sequence for the HSP's. Then they determined the function of the proteins when it wasn't known. Ubiquitin is one protein that is highly upregulated after heat shock. Yet ubiquitin has many functions. It can be a molecular tag signaling for proteasome dependent degradation(ie. IkB), a sorting signal to specific intraceullar compartments(ie. EGF-R), oligomerization of proteins (RIG-I and MDA5), and protein-protein interactions(TAB2/3)
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[Dec 24, 2012 12:37:19 AM]   Link   Report threatening or abusive post: please login first  Go to top 
twilyth
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Re: Trojan Horse Cancer Killer

Yeah, I'm definitely misunderstanding. But in my defense, there is this wikipedia entry on their role as chaperones.

I get my information from lay science publications so I only tend to get bits and pieces. Sometimes I put them together and get the right picture but other times . . .

I used to date a molecular biologist and it would drive her nuts. I would talk to her about some cutting edge research but I wouldn't know most of the basic concepts involved. It's a wonder she didn't strangle me.
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[Edit 1 times, last edit by twilyth at Dec 24, 2012 12:46:13 AM]
[Dec 24, 2012 12:45:33 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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