| Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
 |
World Community Grid Forums
Category: Completed Research
Forum: Help Conquer Cancer
Thread: Trojan Horse Cancer Killer |
| No member browsing this thread |
|
Thread Status: Active Total posts in this thread: 14
|
|
| Author |
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
|
||
|
|
dskagcommunity
Senior Cruncher Austria Joined: May 10, 2011 Post Count: 219 Status: Offline Project Badges: 
|
wow nice :)
---------------------------------------- |
||
|
|
themoonscrescent
Veteran Cruncher UK Joined: Jul 1, 2006 Post Count: 1320 Status: Offline Project Badges: 
|
Good news, but I was wondering what happens to the virus once it had done it's job, I doubt it'll come with a kill switch built in (so to speak)???
----------------------------------------  |
||
|
|
twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2129 Status: Offline Project Badges:
|
If I can take a wild guess, it might be engineered to require and enzyme only produced by tumor cells. According to the article,
----------------------------------------At this stage each white blood cell contained just a couple of viruses. However, once the macrophages enter the tumour the virus can replicate. It sounds like there is something secreted by the tumor that is required for replication.  [Edit 1 times, last edit by twilyth at Dec 21, 2012 8:39:15 PM] |
||
|
|
yojimbo197
Advanced Cruncher Joined: Jun 30, 2012 Post Count: 83 Status: Offline Project Badges:
|
The proteins necessary for viral replication are controlled by a switch. This particular switch is tightly regulated by oxygen tension. At low oxygen tension(hypoxia), which is most common in and immediately around tumors, this switch triggers the production of the viral proteins needed for viral replication within the immune cells/macrophages.
---------------------------------------- |
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Fine !
|
||
|
|
Paul Schlaffer
Senior Cruncher USA Joined: Jun 12, 2005 Post Count: 242 Status: Offline Project Badges: 
|
Thank you for the info, this is an amazing development.
----------------------------------------Anyone who has seen the beginning of the movie "I am Legend" must be experiencing Deja Vu.  “Where an excess of power prevails, property of no sort is duly respected. No man is safe in his opinions, his person, his faculties, or his possessions.” – James Madison (1792) |
||
|
|
twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2129 Status: Offline Project Badges:
|
yojimbo can correct me if I'm wrong but I think all such proteins are called heat-stress proteins - even if the stress isn't heat induced. What I can't remember is if they were first discovered in yeast or not. I'm thinking not since I believe bacteria also produce them, not just eukaryotes, but I can't remember.
----------------------------------------[Edit 1 times, last edit by twilyth at Dec 23, 2012 4:58:48 AM] |
||
|
|
yojimbo197
Advanced Cruncher Joined: Jun 30, 2012 Post Count: 83 Status: Offline Project Badges:
|
Twilyth, you have the right idea(environmental stress), but wrong set of proteins in mind. The switch controlling the expression of viral replication proteins in this experiment is a promoter or binding site if you will for a group of oxygen sensitive proteins called Hypoxia Inducinble Factor proteins(HIF's).
----------------------------------------[Edit 1 times, last edit by yojimbo197 at Dec 23, 2012 9:42:12 PM] |
||
|
|
twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2129 Status: Offline Project Badges:
|
Ah, cool. I just looked both up. So HIF are transcription factors and heat stress proteins are more like chaperonins?
---------------------------------------- |
||
|
|
|