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bassim
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different grids working on Human Proteome Folding ?

hello
There are many web sites [grids] working on the same projects such as Proteome Folding and cancer folding.
Such sites are world community grid, folding@home and www.grid.org

my question is, are all these sites collaborating with each other, or each one is doing its own research causing some folding redundancy?

which site should I fold for to minimize the redundancy?
[Sep 7, 2006 7:05:43 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

You can do all sorts of things by folding. Folding@Home, for example, are mostly concentrating on finding better ways to simulate folding as it happens in real life. Rosetta@Home is looking for practical ways to fold.

Human Proteome Folding uses the Rosetta software to fold proteins concentrating on human secreted proteins and certain proteins known to be involved in certain diseases.

Human Proteome Folding Phase 2 and all future WCG projects are exclusive to WCG. Some previous projects were shared, so that may have led to confusion.

Some grids are less concerned about scientific integrity. For example, grid.org routinely send out old (already calculated) work units when they run short. Some grids actually charge, and keep the results proprietary. World Community Grid does none of this. All results are released into the public domain, and volunteer effort is not wasted.
[Sep 7, 2006 7:34:25 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

Folding@home is a much different thing to this place and grid is, erm, well,[self-edited to save the admins some time] laughing
[Sep 7, 2006 7:35:57 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

Hi bassim,

Grid.org and WCG did work simultaneously on Human Proteome Folding Phase 1 (HPF1) but the crunching for that project is complete. The Human Proteome Folding Phase 2 project is only at WCG. HPF2 is temporarily on hold while they fix a bug.

The Help Defeat Cancer project (HDC) is only at WCG. I don't think any other organisation has a project that is even a little bit similar to HDC. Other projects may be involved in cancer research but their research is different from HDC.

The Fight Aids @ Home project (FAAH) is unique too. There may be other projects working on AIDS but WCG does not collaborate with them and their research is slightly different.

So, the short answer is... WCG is not collaborating with other projects at this time, you could work on all the projects WCG offers with zero redundancy. There is a lot of friendly cooperation between most of the projects but very little reduncancy.

Grid.org has a very bad reputation. Ask around and you will discover they have little respect in the community.
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[Edit 2 times, last edit by Former Member at Sep 7, 2006 9:23:24 PM]
[Sep 7, 2006 7:37:31 PM]   Link   Report threatening or abusive post: please login first  Go to top 
we45dfa35gh3476
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Re: different grids working on Human Proteome Folding ?

Some grids are less concerned about scientific integrity. For example, grid.org routinely send out old (already calculated) work units when they run short. Some grids actually charge, and keep the results proprietary. World Community Grid does none of this. All results are released into the public domain, and volunteer effort is not wasted.


Indeed. The re-crunching of old HPF1 data (I'm not enough of a veteran to remember the re-crunch of cancer) on grid.org irritated me so much (and went on for quite a while)...I yanked all 120 work computers off grid.org and brought them over to the WCG. I like it much better over here biggrin
[Sep 7, 2006 9:03:21 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

I just hope WCG can handle userbase growth better than grid......at least the P.R here is better, ie it exists.

Looks like stats updates may runinto hours rather than minutes in the near future tho biggrin
[Sep 7, 2006 9:06:51 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

Fixing the stats is definitely on the list.

I recall reading somewhere that WCG are prepared to scale up all the way to 10 million users. Sounds like we have plenty of room to grow :-D
[Sep 7, 2006 9:43:26 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: different grids working on Human Proteome Folding ?

I didn't crunch at grid.org so I don't know the history there as intimately as many others. What was the first indication that validated WUs were being resent and recrunched? How did the suspicion begin? How did it grow?
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[Edit 1 times, last edit by Former Member at Sep 7, 2006 11:29:31 PM]
[Sep 7, 2006 11:25:15 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: different grids working on Human Proteome Folding ?

RT archived the discovery on http://www.unofficialworldcommunitygrid.com - don't know if the original is still available.
[Sep 7, 2006 11:32:01 PM]   Link   Report threatening or abusive post: please login first  Go to top 
we45dfa35gh3476
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Re: different grids working on Human Proteome Folding ?

I didn't crunch at grid.org so I don't know the history there as intimately as many others. What was the first indication that validated WUs were being resent and recrunched? How did the suspicion begin? How did it grow?


I don't know about the cancer re-crunch personally, but here's the low-down of the HPF1 re-crunch:

---HPF1 is announced closed over here
---Members (incl. Scribe) ask (on grid.org forum) what we're still crunching with HPF1 after it's closed
---Robby posts member news that HPF1 is not crunching anything new, but he doesn't want to close it yet (no reason given)
---This thread is started...basically saying that we're wasting time everyday on nothing. Stats were posted about how much time was wasted every day (quite a lot) on re-crunching HPF1 for all those users who don't read the forums.
---Finally, after about 2 months, Robby turns off HPF1 and announces it in member news (and this time he says he left HPF1 on because "some people liked the screensaver" - poor excuse IMHO...thousands of users leave the project on without reading the forums & had their time/resources wasted).

So, in this instance, it was admitted after it was announced closed here but left on over there (and people asked - I'm sure nothing would have been announced if no one raised an eyebrow about it). I'm not sure how it went down with cancer data.
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[Edit 3 times, last edit by we45dfa35gh3476 at Sep 8, 2006 1:04:56 AM]
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