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Johnny Cool
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Are we crunchers making any progress?

Like most/many of you, I just keep crunching.

I was not sure where to post this question. thinking

I do realize that Research takes a *lot* of time to announce any new progress with "White Papers" and so forth.

As an IT Recruiter, I fully understand this. I work with Research Labs (not with any "Big Pharma" research labs) besides many Software Development Companies. wink

Every now and Zen, we need to know what progress has been done.

Ah yes, software methodologies comes to mind in this case. Well, maybe.

And while I am at it, when will WCG give us Cancer work units and other worthy projects like Diabetes and many other diseases?

Team Mates want to know. wink

Anything positive ... any news ... we are not DC drones.

I do believe in the power of Distributed Computing. We all do. This why we are all here.

If anything, give us some "smoke signals" that Native Americans used to use. Well, actually, living in Colorado, Native Americans are still taught this very old way of communicating. Many times, better that using cell phones!

'tis their great Heritage. good luck

We often see "burned-out" folks who have stopped crunching. That is rather sad.

WCG, please give us more Progress Reports if you can. wink

I do understand that the majority of all/most DC Projects are still awaiting progress upon further review.

That's why it is called "Research".

I know, I am asking questions that have yet to be answered. Still ...

Many new drugs are "hitting" the Market Place. That is all well and good.

Yet, the search for Cures ....
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[Edit 2 times, last edit by Johnny Cool at May 6, 2006 3:40:27 AM]
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Former Member
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Re: Are we crunchers making any progress?

We just had a load of updates.

HPF: http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7068

FAAH: http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7042

The cancer project will be here "soon". A more precise date would be nice, but we have to assume that WCG will let us at it as soon as they are happy it's bug free. That has been the procedure on previous new features, and it works better than announcing a launch date then having to move it around.
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retsof
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Re: Are we crunchers making any progress?

It's a trade off. Some want more "progress". Others want "something new". If you are running too many projects at once, the progress on each will be slower.

Like others, I think that Cancer will attract lots of new members because of the perceived worthiness of that kind of project. I'm pushing the existing workunits out as fast as I can to both finish them sooner and see something new sooner.

As an IT Recruiter, I fully understand this. I work with Research Labs (not with any "Big Pharma" research labs) besides many Software Development Companies.

Every now and Zen, we need to know what progress has been done.
That brings up a classic situation. If I apply for a job and hear nothing, the lack of information makes me figure I didn't get it. Most companies only send out a progress notice to the one successful candidate.
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[Edit 3 times, last edit by retsof at May 6, 2006 1:46:53 PM]
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Re: Are we crunchers making any progress?

Didactylos says that a Cancer Project will be here "soon". I"m wondering what type of cancer project. As far as I can understand we must first calculate and understand how proteins fold and equally important how they "misfold" before we can understand cancer on any decent level.

So I'm wondering why we don't just focus on getting that done first? Understanding protein folding will not only unlock the doors for a cure for cancer but also a load of other serious disease and conditions.

I'm runnning the World Grid and Stanford protein folding and misfolding project. This requires and enormous amount of my CPU power as the work unit take maybe 1 to 2 solid days of solid 24 hour crunching even on my machine. World Grid typically takes 4.5 hours by contrast.

Just my opinion that PROTEIN FOLDING and MISFOLDING might be a "PREREQUISITE" to finding an effective cure for cancer which would explain why we have had a good success so far. Grid dot org is already working on a cancer project and has been for a while now of which I used to crunch and lost interest and faith in it.

I'm glad to see some updates on the FAAH project. Good to see something is getting done unlike some other project I have dedicated my resources on.
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Former Member
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Re: Are we crunchers making any progress?

Hi rbolo28,

I asked the same question some time ago. You might like to look at the response here:

http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=5471#43988

Cheers
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Former Member
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Re: Are we crunchers making any progress?

How about a straight answer to the most obvious question any member of this Grid could ask. "What are we accomplishing here and what progress have we made in the real world resulting from our contribution here", would somebody competent please answer our members first question
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[Edit 2 times, last edit by Former Member at May 6, 2006 9:45:32 PM]
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retsof
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Re: Are we crunchers making any progress?

This grid crunching is only the first PRELIMINARY phase to what the researchers could hope to accomplish in the real world. We are SCREENING drugs to find promising candidates and folding proteins to analyze their structure. The researchers have to compile the findings at the conclusion of the project and write any research papers and publications in future phases. Some of that might even call for some recrunching, as in Rosetta phase II.

"Mr. Edison, have you invented the light bulb yet?"

"I don't know, son. It's still pretty dark around here. I have a few thousand other filament combinations to try first."

And then, there's the power plants, dynamos, distribution system, transformers, appliances, watt-hour meters, motors and even electric bills. Sorry, I have to get back to work on that light bulb. There later turned out to be 25 designs for light bulb bases and many patent disputes over 13 years until the Edison socket won out.
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[Edit 3 times, last edit by retsof at May 6, 2006 9:49:59 PM]
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Former Member
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Re: Are we crunchers making any progress?

This grid crunching is only the first PRELIMINARY phase to what the researchers could hope to accomplish in the real world. We are SCREENING drugs to find promising candidates and folding proteins to analyze their structure. The researchers have to compile the findings at the conclusion of the project and write any research papers and publications in future phases. Some of that might even call for some recrunching, as in Rosetta phase II.

"Mr. Edison, have you invented the light bulb yet?"

"I don't know, son. It's still pretty dark around here. I have a few thousand other filament combinations to try first."

And then, there's the power plants, dynamos, distribution system, transformers, appliances, watt-hour meters, motors and even electric bills. Sorry, I have to get back to work on that light bulb. There later turned out to be 25 designs for light bulb bases and many patent disputes over 13 years until the Edison socket won out.


Spare me the Edison, Tesla Quotes, many of us here do not "worship his shaddow", what I would like is an answer to the first question.
or at least a competent explanation of the process.
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[Edit 3 times, last edit by Former Member at May 6, 2006 10:56:42 PM]
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Re: Are we crunchers making any progress?

What we do here is basic science. Universities and research labs with projects requiring a lot of computing power come to the WCG, and we crunchers do the hard work. Note that the big pharmaceuticals can go and buy their own supercomputers - WCG have strict entry requirements.

So, the lab will have designed an experiment, written the code, and created the input data. We do the crunching. The lab gets back the results. They analyse the results, in the context of their experiment. They write a paper. Probably several papers (these are big experiments we're doing here). This takes time. They will publish in peer reviewed journals, present their findings at international conferences, all that jazz. The HPF project has just started publishing now, after a couple of years of crunching. But now they've started, we can expect to see more papers coming out, since they are still getting new data all the time.

If you are interested, there are previous papers available published by the FAAH lab and the HPF lab, which give a lot of the context for these projects.

What happens to the published research after that depends on the project. FAAH are searching for candidate drugs. Their findings will go through several phases of testing and trials, hopefully ending in successful human testing. This process takes a fair few years, as well. It is likely that the later phases will be undertaken by other labs and drugs companies.

The HPF results are slightly different. They are going to be useful in all sorts of other research projects. The predicted structures may well be used in future crunching projects, to find drugs for specific diseases.

Protein misfolding is an entirely different problem, and is being worked on by a different project.

So, what difference have we made in the real world? Well, so far some scientists know a lot more than they did, and the FAAH scientists have already found some good leads for further testing.
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Re: Are we crunchers making any progress?

Thankyou Didactylos
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