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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges: ![]() ![]() ![]() ![]() |
http://www.popsci.com/science/article/2012-08...be-harnessed-fight-cancer [...] HIV-derived protein factories could pump out generations upon generations of new molecules and drug compounds to help alleviate a wide range of illnesses. [...] This is the first time I would thank HIV for anything. |
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Michael2901
Veteran Cruncher Joined: Feb 6, 2009 Post Count: 586 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
http://www.bio-medicine.org/biology-news-1/Un...y-news+%28Biology+News%29
"Date:7/24/2012 Under the right conditions, peptide blocks HIV infection at multiple points along the way Human defensins, aptly named antimicrobial peptides, are made in immune system cells and epithelial cells (such as skin cells and cells that line the gut). One of these peptides, human neutrophil peptide 1, under certain circumstances hinders HIV infection, but exactly how it works remains unclear. HIV entry into mature T-helper cells (cells essential to the immune system) proceeds by attachment of the virus to specific targets on T-helper cells, uptake of the virus, fusion of its envelope with the cell membranes, and release of the virus into the cells. In a forthcoming Journal of Biological Chemistry Paper of the Week, Gregory Melikyan at Emory University and colleagues investigated the ability of human neutrophil peptide 1 to impede each step of this process. |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges: ![]() ![]() ![]() ![]() |
The Path to a Cure
"...To be clearer, HIV requires bonding at two sites in order to gain entry into human cells: the CD4 receptor site and a chemokine receptor site, most commonly CCR5. When a person has both genes (homozygous) carrying the delta 32 variant, it results in a deletion of the gene that, under normal circumstances, selects for the CCR5 chemoreceptor. In other words, it results in them lacking CCR5, a protein on the surface of immune cells that HIV uses to gain entry. In this situation, HIV is disabled from gaining entry or infecting human cells. Roughly 1% of Northern Europeans possess this abnormality. Other individuals that are heterozygous and have the genetic modification in only one gene are not protected." http://www.thebody.com/content/65775/the-path-to-a-cure.html Can HIV Infection Be Cured? "...There are ongoing research efforts in several areas: Clearing out reservoirs of infection Vaccinations to help the immune system fight HIV (therapeutic vaccination) Making cells resistant to HIV Modifying stem cells Many researchers believe that a cure will require a combination of approaches." http://www.thebody.com/content/67370/can-hiv-...e-cured.html?ic=sadefault |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
WCG's crunching calculates inter-molecule bonding strength - this new technology can directly measure inter-atom bonding strength within a single molecule!
http://arstechnica.com/science/2012/09/atomic...rength-of-chemical-bonds/ The covalent bonds that hold complex molecules together can come in different forms. Atoms like carbon, nitrogen, and oxygen can form both single and double bonds, sharing two or four electrons. Nitrogen and carbon can even form a triple bond, sharing six. And those are some of the simpler ones. A mixed series of single and double bonds, like those found in benzene, can end up creating a diffuse electron cloud, so that each of the bonds has an odd number of electrons. The exact strength of these bonds depends strongly on the context of the surrounding molecule. It's possible to get a variety of information about these bonds. We could calculate what their energy is, probe them with chemical reactions, and could even detect the difference in bond strength by imaging the structure of a crystalized population of molecules. But now, a consortium of researchers in Europe have figured out how to use a modified form of atomic force microscopy to examine the strength of chemical bonds in a single molecule. [...] the authors were able to discriminate down to bonds that differed by only 0.03 Angstroms (3.0 × 10-12 meters). [...] Molecules that don't form crystals easily could be imaged with this technique, and the extremely precise control could allow researchers to inject electrons or probe chemical conditions at specific points in a single molecule. [...] |
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Michael2901
Veteran Cruncher Joined: Feb 6, 2009 Post Count: 586 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
http://www.bio-medicine.org/biology-news-1/Co...y-news+%28Biology+News%29
"Date:8/26/2012 Compound discovered that boosts effect of vaccines against HIV and flu Oxford University scientists have discovered a compound that greatly boosts the effect of vaccines against viruses like flu, HIV and herpes in mice. An 'adjuvant' is a substance added to a vaccine to enhance the immune response and offer better protection against infection. The Oxford University team, along with Swedish and US colleagues, have shown that a type of polymer called polyethyleneimine (PEI) is a potent adjuvant for test vaccines against HIV, flu and herpes when given in mice. The researchers were part-funded by the UK Medical Research Council and report their findings in the journal Nature Biotechnology. Mice given a single dose of a flu vaccine including PEI via a nasal droplet were completely protected against a lethal dose of flu. This was a marked improvement over mice given the flu vaccine without an adjuvant or in formulations with other adjuvants. The Oxford researchers now intend to test the PEI adjuvant in ferrets, a better animal model for studying flu. They also want to understand how long the protection lasts for. It is likely to be a couple of years before a flu vaccine using the adjuvant could be tested in clinical trials in humans, the researchers say. 'Gaining complete protection against flu from just one immunisation is pretty unheard of, even in a study in mice,' says Professor Quentin Sattentau of the Dunn School of Pathology at Oxford University, who led the work. 'This gives us confidence that PEI has the potential to be a potent adjuvant for vaccines against viruses like flu or HIV..." |
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Michael2901
Veteran Cruncher Joined: Feb 6, 2009 Post Count: 586 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
http://www.bio-medicine.org/biology-news-1/Po...y-news+%28Biology+News%29
"Date:8/9/2012 Potential drug molecule shows enhanced anti-HIV activity Researchers from Munich and Naples have shown that minimal modification of a synthetic peptide with anti-HIV activity results in a new compound with more than two orders of magnitude higher binding affinity to the chemokine receptor CXCR4 and greatly improved anti-HIV activity. This could be a step toward the design of new, more effective drugs against AIDS, inflammatory diseases, and some forms of cancer. Different strains of HIV-1 use either the chemokine receptor CCR5 or CXCR4 for entry into immune cells. While drugs that block usage of CCR5 by the virus are already available for anti-HIV therapy, no drugs have been approved that prevent the virus from using the CXCR4 receptor. Because the new cyclic peptide may be used to block CXCR4, it is a promising new drug candidate to block HIV-1 infections..." |
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robertmiles
Senior Cruncher US Joined: Apr 16, 2008 Post Count: 443 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I just found some information on a research program for creating a cheap way for mothers to keep from passing their HIV along to children they are feeding with their breast milk.
It seems that passing electricity through some liquids will inactivate any HIV they contain. Breast milk is one of them. A group at North Carolina State University (NCSU) is developing a baby bottle that will create electricity if shaken, and pass it through the bottle's contents. A battery or hand-cranked generator can also be the energy source. This does take some extra time to put the breast milk in the bottle, though. No web link available. |
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Michael2901
Veteran Cruncher Joined: Feb 6, 2009 Post Count: 586 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Web link to the above referenced article is as follows:
http://www.engr.ncsu.edu/magazine/fall2012/seniors.php |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
http://www.dailymail.co.uk/health/article-222...ce-milk-protects-HIV.html
The amazing new treatment using COW'S MILK that could prevent HIV PUBLISHED: 05:24 EST, 24 October 2012 [...] scientists, led by Dr Marti Kramski, vaccinated pregnant cows with an HIV protein and studied the first milk that cows produced after giving birth. The first milk, called the colostrum, is naturally packed with antibodies to protect the newborn calf from infections. The vaccinated cows produced HIV antibodies in their milk. 'We were able to harvest antibodies specific to the HIV surface protein from the milk,' said Dr Kramski. 'We have tested these antibodies and found in our laboratory experiments that they bind to HIV and that this inhibits the virus from infecting and entering human cells.' The HIV-inhibiting antibodies from cows’ milk will be developed into a cream called a microbicide that is applied into the vagina before and/or after sex to protect women from contracting sexually transmitted infections. Other microbicides are being developed around the world but the antibodies in this research are easier and cheaper to produce, providing a new HIV-prevention strategy. [...] |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges: ![]() ![]() ![]() ![]() |
"... elite controllers suppress HIV by generating a powerful CD8+ T killer cell response against just two or three small regions of the virus."
http://www.nlm.nih.gov/medlineplus/news/fullstory_129787.html |
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