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The red spirit
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OpenPandemics and other projects

Hi,
I want to know what is the difference between Open Pandemics (WCG subproject) and other distributed computing project. I'm talking about Folding@Home, Rosetta@Home, GPU Grid, Ibercivis BOINC.

I tried to search for info myself, here's what I found:
Folding@Home - precise simulation of protein folding
Rosetta@Home - somewhat streamlined folding simulation
WCG OpenPandemics - barebones folding simulation with highest focus on folding results rather than folding process
GPU Grid - no idea, nVidia only project
Ibercivis - no idea

I sorta tried to keep track of Folding, Rosetta and OpenPandemics at first, but some time later I forgot most of what makes them different. At this point I'm not even sure what differences they have, but it seems that some projects overlap and do same work as others. Folding@Home for some reason is the most popular one, but from what I understand OpenPandemics should be the quickest to find some rough solutions. Then Rosetta and Folding would examine known results in greater depth. GPU Grid and Ibercivis joined really late and at this point they seem to be pointless. Also Rosetta seemed really lively at first, but right now it's seemingly dead and some people are talking in forums that Rosetta might be ending altogether and that their work will move to some other platform, which will have GPU crunching support.

Please, enlighten me about all those projects and what are they doing differently.
[Nov 10, 2020 6:29:00 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Jim1348
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Re: OpenPandemics and other projects

To further confuse the issue, you missed SiDock@home, an interesting new one.
https://fightcovid.boinc.ru/sidocktest/

Here is my quick, non-expert overview:
In general, OPN, Ibercivis and SiDock are "docking" programs that try to find the molecule (a ligand I think) that best attaches, or "docks" to the target virus. The purpose is to disrupt its function. In some cases, they may even dock to the ACE2 protein that you are trying to protect from the virus.

At any rate, Folding tries to find the weak points in the virus that are useful to attack. They can examine the virus in great detail at high speed.
https://foldingathome.org/2020/07/26/citizen-...puter-to-combat-covid-19/

And Rosetta tries to construct proteins that can "cap" the virus to protect the ACE2 protein on the surface of the lungs it from the virus.
https://www.youtube.com/embed/ODEIN5V3yLg
Rosetta is far from dead. It is making great progress. But they are past their first phase, and may not need to be doing so much COVID work any more, unless the virus mutates.

PS- GPUGrid is a very nice project. I usually keep a couple of cards on it.
But they are not doing anything specifically for COVID. There are other things to deal with.
Folding and Rosetta also do a wide variety of work. I have supported them both for many years.

PPS: This give a bit of background on how Folding relates to docking.
https://foldingforum.org/viewtopic.php?f=17&t=35110&p=336603
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[Edit 6 times, last edit by Jim1348 at Nov 10, 2020 9:10:47 PM]
[Nov 10, 2020 7:06:59 PM]   Link   Report threatening or abusive post: please login first  Go to top 
robertmiles
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Re: OpenPandemics and other projects

Ibercivis is currently only for those who can follow instructions written in Spanish.

GPUGrid did some work that is now used for COVID-19 projects, such as the virus caps, but has finished that work.

I've seen a project at https://covid.si/en/ mentioned, but have not investigated. Probably a non-BOINC project.

Folding@home main (non-BOINC)

https://foldingathome.org/

Folding@Home Forum (separate account creation required)

https://foldingforum.org/index.php


Quarantine@Home (GPU only for Linux) (probably non-BOINC)

https://quarantine.infino.me/


TN-Grid does not want to be mentioned much until they install a new server. Genetic work affecting COVID-19.


BOINC projects are set up to be compatible with other BOINC projects on the same computer. Non-BOINC projects are difficult to make share a computer with any other project.

I've seen recent articles saying that a mutated version of the virus is affecting mostly mink farms and humans near them. The mutation affects the spike protein, and therefore any treatment aimed at the spike protein may need more work to handle this mutation.
[Nov 11, 2020 1:08:31 AM]   Link   Report threatening or abusive post: please login first  Go to top 
robertmiles
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Re: OpenPandemics and other projects

English study suggests T cells could be sufficient to protect from COVID-19

https://www.reuters.com/article/us-health-cor...om-covid-19-idUSKBN27Q004
[Nov 11, 2020 1:09:54 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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