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poppageek
Advanced Cruncher Joined: Nov 16, 2004 Post Count: 99 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
OK boys, you heard the lady. Let's get to work! CRUNCH!!
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
We are committed to releasing all the docking results to the public as soon as we get them Thank you Carol, that one line very directly removes any doubts that we're making me wary, that was all I needed to hear and thank you very much for clarifying it. |
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poppageek
Advanced Cruncher Joined: Nov 16, 2004 Post Count: 99 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
From the OpenZika project web site.
----------------------------------------FAQ answer to second question: How might the ...eful to Zika researchers? In compliance with World Community Grid policy, the researchers will make their data openly accessible, thereby allowing other scientists to apply their own methods and approaches to further study promising compounds. The open data component of this project (and all other World Community Grid projects) means that the likelihood of finding effective drug treatments for Zika may be higher than if the researchers worked in isolation. http://openzika.ufg.br/help-to-fight-zika/ OpenZika Project Project Goal The main goal of the OpenZika project is to screen millions of compounds from existing databases against homology models of Zika protein structures as well as against experimentally determined Zika protein structures, as soon as these are known. These screening results will all be made publicly available, opening the door for other scientists to also use these data to help develop Zika treatments. [Edit 2 times, last edit by PoppaGeek at May 24, 2016 5:45:20 AM] |
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hiimebm
Senior Cruncher United States Joined: Oct 19, 2014 Post Count: 305 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Good thing they clarified; this thread was about to get heated to hotter than a Pentium 4 (aye?).
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MrKermit
Advanced Cruncher Joined: Jun 13, 2009 Post Count: 95 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I am very fortunate that Carolina and Alex have agreed to volunteer their time as well to get this off the ground - without them this would not have happened because as a company I could not have done this WCG project. That was clear from the outset. I had the idea and the motivation but Carolina and Alex have the facilities and expertise to make this happen. Please support us as we and our collaborators try to identify drugs active against Zika ASAP. We need YOU! I would propose amending your statement to "We, the people of the world, are very fortunate..." Let me explain. Compute cycles are everywhere, and lost to time because people don't donate their idle time to researchers. We all know that, that's why we are on WCG! Researchers with the ability to put that otherwise idle/lost computational time are actually the scarce resource. It doesn't matter who profits in the end, it's not about the efficiency of the computer systems, the time would otherwise have been wasted. It has a slight marginal cost in power consumption. The incredible inefficiency in the system is the utilization of the researchers' minds. These extremely rare, specialized talents, that take decades to specialize and are pulled in many directions to put their ideas through scientific rigor. They have to train their replacements, search for grants, beg for time and attention to their ideas. If a researcher can fully test 1 idea in 6 months, then doubling their compute time might get them the answer in 3 months. Doubling the productivity of that rare, specialized skill. If they become billionaires, they'll still research. It's what they do. They will spend the Billions on more research. Their own, and the promising work of their peers. I'm Ok with researchers joining the Billionaire Class... They'll get more done and we'll get more researchers! This is why I chose my Nick, "It's not easy being Green." I pay crazy power bills every month, but research computers have a very short life and the best way to make sure they reach their full potential is to keep them busy doing research, even if it's donated time like WCG some times. We get paid for some time on our computers, but we give away what we can too. The best way to help these researchers reach their full potential, is to get them every cycle we can, and hope to 2x, 10x, or more their productivity. Regardless of who turns it into cash. Trying to rationalize donating an otherwise wasted resource is futile. If you had a pile of paints going bad, wouldn't you give them to an artist even if he may sell the painting some day?! Godspeed Researchers! If you need to run any MPI / Parallel codes give me a shout. We have Infiniband on all these nodes, so they can do some things WCG can't. We even have a couple GPU's and Intel XeonPhi cards to test on. Sincerely, MrKermit ![]() |
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BladeD
Ace Cruncher USA Joined: Nov 17, 2004 Post Count: 28976 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
OK boys, you heard the lady. Let's get to work! CRUNCH!! ![]() Cheers! Ditto! |
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Bearcat
Master Cruncher USA Joined: Jan 6, 2007 Post Count: 2803 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I really don't care who comes in to start a project on WCG as long as ALL results go public to everyone at the same time. No reason to bash someone who has a legitimate question. Once the question has been answered, then up to all of us to decide if we choose to volunteer our computers. It was a good question and the scientists answered. I will be staying!
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Crunching for humanity since 2007!
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I do not know HFCC, but in my mind that is a tragedy - if the motivation is making money. There has to be a way to bring to patients. One of the companies I co-founded (Phoenix Nest) works on Sanfilippo Sundrome MPS IIID. We know of only 2 patients in the US. We were still able to work with an academic institute, get NIH grant funding to support developing a treatment. We had to have a 12 page commercialization plan . Without that the reviewers would not fund it. So bottom line market size should not be a consideration. If the science is there and the NIH or other group supports it, it can be done. The drug ultimately will not be cheap (several years from clinic at least) to recoup the costs but investment of several million $ can lead to therapeutics, does not need to be billions. well, as internet is a "large base of data", that data can be accessed for something else than pop/film stars, videos, facebook or porn... several months ago a member of higher rank in R&D of LG was associated with the CEP2 project here...to this day, no explanation has been given from CEP2 project leaders or WCG...in my opinion: "LG is a large company, that can fund it's own research...taking such undisclosed unfair opportunity is something I personally don't like...so I pulled all my grid computers from CEP2 research, after donating 2y worth of data to them!" some allegations have been raised to FAH & FAHB project...for those, we got some answers, so I continued to support that project! & it's not that I like private companies that are associated with this projects here...just that some of us (including myself) want to hear what is the position of the associated business! yes, we do know that clinical trials, manufacturing a prototype & later manufacturing costs money...& we're OK with it! just that we'd like that "research pages be made public" regardless if it's access for yourself as a company or any other player on the market...& that in this 1st stage of the research "no patents" will be made...so it's upon 2nd stage of the project that scientists (including yourself), can select some of the candidates for a cure, test them & then possibly patent them... the idea is simple: getting so much screened candidates of, makes: 1. faster approach to testing a better candidate 2. lower cost of R&D 3. lower patent costs 4. (& eventually) lower cure costs so, you might say some of us here are against a total "neo-liberal capitalism", while we are in the same time for a less money oriented way similar to "Nordic capitalism"...as WCG is a way to make some cures cheaper & available to all public - including Africa & South America! hope you do see some of the concerns, as we raised this questions...as some of us donate a 1/10 of our income to electric costs & computer parts (maintenance)! ![]() |
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
I have a question regarding the ethics and legitimacy of this project for BOINC. Reading about the OpenZika project, I noticed one of the lead principal researchers is CEO of Collaborations Pharmaceuticals, Inc. This piqued my curiosity. I did a little research on this company. It is a for profit biotech research company. I've been involved in a number of BOINC projects. It's always been my understanding that all projects are OPEN, academic and/or govt. sponsored but not associated with for profit companies. The knowledge gained from BOINC projects is suppose to be for the equal benefit of all researchers world-wide. Collaborations, it appears, partners with numerous not for profit research facilities at medical universities. For a for profit research company isn't that akin to insider trading? Collaborations is in the business of not only computational investigations, but taking those findings and advancing them to clinical stage trials and ultimately to successful drugs/vaccines. This gives Sean Ekins’ company an unfair advantage over all the other companies trying to find answers for Zika. As the article states "Our work on World Community Grid is only the first step in the larger project of discovering a new drug to fight the Zika virus. Next, we will analyze the data obtained from World Community Grid’s virtual screening to choose the compounds that show the most promise. After we have selected and tested compounds that could be effective in killing the Zika virus, we will publish our results.” I own shares in 3 different bio-tech companies that are working on the Zika virus and have been since the outbreak in 2015. Some who have also been working on ebola and dengue for several years. They'd be at a disadvantage getting this information AFTER Ekins company has had the information for some time before it's published. It could be many months, to years, in advance of the rest of the research community. They could begin investigating the first compounds as they complete project testing that show promising results. Everyone one else will only get that information after millions have been put through the entire process. It seems to me that some researchers, who have previously worked on other BOINC projects, have now gone on to advising and working in major roles with new projects, while associated with or having founded their own private for profit companies, taking advantage of their "inside" information. THIS IS USING BOINC FOR PRIVATE FINANCIAL GAIN---completely against the principals which it was developed for and why most of us volunteer our computers computational power and time. If I've evaluated this incorrectly, I'd appreciate someone clarifying it for me. Although I think the Zika virus needs an all out effort by everyone, I won't be volunteering my computer for this project until I'm sure this isn't a round about way of using us and our computers for private advantage and gain. seems to me, that there's a lot of "private interest" in the initial post as well...as I do also own shares, just not in any of the pharmacy industry - so I can relate to that question asked! but, let me give you (rac-ram) some idea...why don't you also collaborate on this research with your companies? You're a share-holder after-all, so ask them...collaborate on this like a partner & sign in all computers in those companies to WCG & Zika research...what is the benefit? - you'd be secure for your investment - companies will get data as a partner - & WCG/Zika project will get a large portion of computing power so, this topic (unlike any of our previous) is "privately funded" with your money against OpenZika project...that's why this topic didn't succeed & I was waiting for explanation from the scientist to stick this "privately funded sticker" to your forehead! now you have some options: - get your companies in research project OpenZika - or just stay quiet, like you did before with not writing at all on this forum have a great day, ![]() ---------------------------------------- [Edit 1 times, last edit by KLiK at May 24, 2016 6:45:16 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
OK boys, you heard the lady. Let's get to work! CRUNCH!! ![]() Cheers! You have got my vote, it was right to ask, I have read your comments along with the counter arguments and on balance (always risky) feel content. |
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