Data published in 2012 by Dr. Feghali-Bostwick demonstrates that certain endostatin-derived peptides are useful for both inhibition and reversal of fibrosis in preclinical mouse models of fibrosis as well as in human skin (Science Translational Medicine, 2012). iBio has initially expressed the active pharmaceutical ingredient for this product using its patented iBioLaunch™ technology, and plans to make clinical development of this product a key priority in the proprietary application of iBioLaunch.

People who have suspected idiopathic pulmonary fibrosis (IPF) without typical patterns on high resolution computed tomography scans could in future be spared the substantial risks of lung biopsy and be given a confident diagnosis of IPF based on clinical and radiological findings alone, according to new research published in The Lancet Respiratory Medicine.
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HRCT scans of the lungs can identify typical 'honeycombing pattern' of lung scarring and damage to the air sacs known as usual interstitial pneumonia (UIP) in people with IPF. In a patient with progressive breathlessness who has no significant environmental exposures attributable to pulmonary fibrosis, or evidence of collagen vascular diseases, the UIP pattern on HRCT is characteristic of IPF. When patients suspected to have IPF do not have the definitive UIP pattern on HRCT images, international guidelines recommend a surgical lung biopsy to make a confident diagnosis of IPF in such patients.

Pacific Therapeutics Ltd. lead drug candidate for fibrosis (progressive scarring of the organ), PTL-202 is a combination of Pentoxifylline an FDA approved drug and N-Acetyl-Cysteine (NAC) an amino acid and an extremely potent and important antioxidant. The Company has completed an initial clinical trial of the combination with positive results. "It's estimated that 45 % of all deaths are related to fibrotic changes" World Health Organization Feb, 2008.