| Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
 |
World Community Grid Forums
Category: Completed Research
Forum: Help Cure Muscular Dystrophy - Phase 2 Forum
Thread: What's next for the HCMD2 results? |
| No member browsing this thread |
|
Thread Status: Active Total posts in this thread: 4
|
|
| Author |
|
|
ngmwcg
Cruncher Joined: Jan 2, 2010 Post Count: 18 Status: Offline Project Badges: 
|
I'm curious what's next for the HCMD2 results? Is the data already being used in the lab to synthesize potential therapeutic compounds? Or is the scope of this project right now to first finish the results, then publish them for future usage? Will these results be consolidated with others in a massive human proteome database (as was done for the human genome project)? Does the team expect to do more computational work on a subset or all of the HCMD2 results? In other words do you anticipate an HCMD3 or are we nearing the end of the compute heavy work, in which things will transition to lab and clinical work?
No need to answer all of these questions individually, just curious if anyone had any insight. Whatever the team wishes to share would be interesting and greatly appreciated. Thanks -NGM |
||
|
|
Randzo
Senior Cruncher Slovakia Joined: Jan 10, 2008 Post Count: 339 Status: Offline Project Badges: 
|
Hellou.
This project is inspectiong protein-protein interactions so they cannot synthesize potentional drug candidates. (it is more like basic research) Speculations about HCMD3 are far far away. We need to finish this project and scientists need a lot of time to analyze results. Wich them good luck. |
||
|
|
ngmwcg
Cruncher Joined: Jan 2, 2010 Post Count: 18 Status: Offline Project Badges:
|
That's along the lines of what I would expect, but to simplify my question; are scientists already studying the results or must the project complete in it's entirety before results are published and available for study?
|
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello ngmwcg,
I don't know the answer to your question for certain, but one way to try to find out is to read all the posts by Alessandra Carbone using Search. Here are 2 relevant posts: 24 Dec 2010 a short upgrade in this Christmas evening to say once more thank you and to give you some idea of what we are doing at the moment. We are ultimating the analysis on the data obtained on phase 1 and hopefully we shall give you some update on this soon. We also started the tests on the prediction of co-evolution signals between protein interfaces. Roughly, we study the hypothesis that during its evolution a protein that changed a residue on its interface induced residue changes also on the interface of the partner. We should be able to trace these changes that occurred between partners. We know this observation to be true for several protein pairs but we are trying to refine our method for a large scale analysis to apply it afterwards to the set of proteins you are docking. This approach, combined with other results, should help to sharply discriminate between protein partners and proteins that do not interact. 2 Feb 2011 the HCMD project considers 2200 proteins and a bit more than 200 of them are known to be involved in muscular dystrophy. all remaining 2000 proteins exist in the cells but are unknown to interact (yet) with the 200 and/or to be involved in muscular dystrophy. The project will end up to point out all possible interactions of the 2200 proteins, even those that do not have something to do with MD. Hopefully the results will be of biological and medical interest to many researchers and will help the understanding of several forms of neuromuscular diseases. To me, this sounds as though we need all 2200 proteins before we can test all possible interactions, although we can and must test the software before we have our complete list for testing. Lawrence |
||
|
|
|