I agree about the reliability of SSDs and have not been worried about that aspect. My main desktop machine is an i7 Shuttle with an SSD for the system drive and a 2tB spinning drive for data. The page file is on the SSD although it probably doesn't get as much wear as one might expect since the machine has 6gB of RAM. The main hassle, if I could call it that is trying to keep the 80gB SSD no more than half full. This means installing some of the more porky programs and those which are seldom used on the spinning drive.

Right now I'm considering building the next machine on a mini-ITX motherboard and having nothing but an SSD installed along with a thinline DVD and a flash reader. Biggest question is whether it would be worthwhile installing a graphics card which can crunch or to stick with the onchip graphics solution to minimize power usage.