Hello haroldlberk,

There is a quicktime movie showing a protein (Ubiquitin) being folded by Rosetta that the ISB links to at the bottom of the Rosetta section of the ISB Human Proteome Folding Project web page at http://www.systemsbiology.net/Scientists_and_...e_Folding_Project#Rosetta

The movie takes a long time to load and is not very informative. It is a very jerky stick figure. But the web page is very informative about the HPF project.

Hello Christine MH,

Your questions are addressed in the status updates at:
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=3563#26720
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=3345#21550
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=3206
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=2885
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=2607
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=2608

My interpretation is at http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=3620#27782

Notice that the ISB intends to produce a number of different online databases. My guess is that they will produce one per species. The initial database [the one that will be their defacto testbed] will not be the gigantic human database.

Hope this helps. Be sure to look at http://www.cytoscape.org/
mycrofth

Hello qliner,

[Grin] See above. My guess [I am a volunteer for the World Community Grid] is that the ISB scientists will start out by running Cytoscape to develop long lists of interacting networks of proteins. Of course, they will try to take advantage of any prior research in other species. And lots of people will become more familiar with database issues than they would have expected when they first began studying Biology back in school. And when they start publishing, a lot of other scientists will start looking at the online databases. And then ... and then ... well - - we will just have to wait and see.

We hope that this will generate a lot of useful hypotheses about the basic processes of cell biology. More specifically, we hope that some of these hypotheses will suggest useful directions for medical research and better treatments for human diseases.

look up one in the forum for the HPF post : "HPF update:"

we try to put one up every month of so. In short we're 80% done so far.

the next phase of the project will hopefully be a higher resolution study of
a few of the proteins that look interesting from this round (using a different algorithm)

Sorry to be picky, but I think this intro needs work. While I understand what you are getting at, I think it is unnecessarily confusing.

" What is a protein?

Proteins are far from being just things we eat. They are the molecular machines that carry out metabolism, they carry messages that direct development and enable the immune system to tell friend from foe, they repair damage to our DNA after we’ve spent too much time in the sun. In short proteins are at the center of Human biology, all biology."

Additionally, under the heading "Which Proteins are Important", second paragraph, the following sentence need a question mark:

"Can you imagine trying to fix a car or a machine knowing the function of only 60% of the components. "

Everything else looks good, but I have a significant organic chemistry background, and found it over simplified.

Hope this helps!