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JmBoullier
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Re: Welcome to the Influenza Antiviral Drug Search project

I have tested this on my Ubuntu box and it shows the graphics same as what is shown in the screen shot above.

I was afraid you would say that! smile
So maybe I will have to find what is wrong in my setup. I say "maybe" because if I am alone with this problem I don't really care: generally I look at the graphics for the first WUs and then I seldom start them.

For the record I am using Ubuntu 9.04 too, and the BOINC and IBM logos are there in fact, they are just so small that I had not seen them when I wrote my first post!

Cheers. Jean.
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[May 6, 2009 11:32:17 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project

awesome 1 WU - 1 result, no "wasting" (i know checking if the result is ok isn't really a waste)

This sounds like a very interesting project, are we only looking for drugs to combat animal based influenza, like the current H1N1 or bird based, or are we looking to fight human only influenza too?

(yes, we won't try to cure H1N1, it's only an example biggrin )
[May 6, 2009 5:29:57 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project

http://www.USA-NCI.com

Concanavalin A, constructs the NCI-1, has several scientic literatures to demonstrate to against all Type A influenza virus. The memorial cytotoxic T cells can exist / last for 1 year more. In Asia, many Type A influ patients were health restored or prevented.

Concanavlin A in NCI-1 to Anti-Type A Influenza
Nature 288, 164 - 165 (13 November 1980); doi:10.1038/288164a0
Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line
LIN YUN LU & BRIGITTE A. ASKONAS*
National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
*To whom correspondences should be addressed.
Spleen cytotoxic T cells killing influenza virus-infected target cells are cross-reactive for the different type A influenza viruses, in contrast to the circulating antibodies, which show fine specificity for each A virus subtype variant1,2. This finding has raised the question of whether a single T cell can recognize cells infected with all the type A viruses. T-killer cell lines with specificity for alloantigens and the male Y antigen can be selected by means of growth factors present in the supernatant of T cells stimulated with Concanavalin A (refs 3−7). We report here that we have been able to establish clones of mouse T cells killing target cells infected with influenza virus. Our cell line maintains the same specificity as the heterogeneous spleen cell population from infected mice, in as far as the T-killer cells are specific for A influenza virus, but do not discriminate between the different type A viruses. The cell line maintains H−2 restriction and does not kill cells infected with B influenza virus. The cells grow in the presence of T-cell growth factor and do not require antigen for growth although they maintain their receptors for type A virus. They can also be stimulated by irradiated T-helper cells from mice primed by type A influenza infection in the presence of type A virus-infected cells.

http://www.USA-NCI.com


Activation of influenza-specific memory cytotoxic T lymphocytes by Concanavalin A stimulation
Maya Tsotsiashvilli, Raphael Levi, Ruth Arnon and Gideon Berke*
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Received 20 July 1997; revised 23 September 1997; accepted 25 September 1997.
Available online 21 May 1998.
Abstract
Traditionally, the in vitro activation of virus-specific memory cytotoxic T lymphocytes (CTLs) has been achieved by stimulating the CTLs with antigen-presenting cells (APCs) infected with an appropriate virus or pulsed with virus-specific antigenic peptides. Here, we describe the utilization of the polyclonal activator Concanavalin A (Con A) for in vitro restimulation of memory CTLs from virus-primed mice. Using this simple method, the activation of splenocytes with Con A for 3 days (i) eliminates the need to stimulate with virus-pulsed APCs and (ii) generates CD8+ CTLs that exhibit virus specificity and MHC-restricted lytic activity similar to CTLs obtained by conventional viral restimulation. In vitro Con A stimulation of splenocytes from BALB/c mice primed with the A/Texas/77 or A/Japanese/57 strain of influenza virus and from C57L/J mice infected with the A/Texas strain, generated CTLs with specific lytic activity. Hence reactivation of memory CTLs by this method is a general phenomenon rather than a mouse or viral strain-specific one. The Con A stimulation method used here had a recall of long-term (1 year) memory CTLs that effectively lysed virally infected targets. Further Con A-stimulated effector lymphocytes from virally primed animals have been shown to recognize and subsequently lyse target cells pulsed with virus or virus-derived peptides. The Con A reactivation of specific anti-viral CTLs may facilitate (i) studying anti-viral CTL responses and (ii) identifying of viral epitopes when unknown or when appropriate viral stimulation is impossible.
( http://www.USA-NCI.com )
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Re: Welcome to the Influenza Antiviral Drug Search project

H1N1 is a human influenza. It was responsible for the Spanish Flu pandemic in 1918-1920.

There are different strains of H1N1, some endemic in humans, others in other species. The project is studying neuraminidase, one of the proteins found on the surface of the influenza virus. The project is studying many variants, including N1 - the same N1 that H1N1 is named after.

So, yes, the project is looking for drugs to treat H1N1.

If you were asking whether the project will also look at influenza B, which almost exclusively infects humans, then I think so, because that virus is also covered in hemagglutinin and neuraminidase.
[May 6, 2009 5:57:16 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project

So maybe I will have to find what is wrong in my setup. I say "maybe" because if I am alone with this problem

You're not alone ;)


Fedora 10, Intel Corporation Mobile 945GM/GMS/GME, 943/940GML Express Integrated Graphics Controller (rev 03), BOINC 6.4.4
[May 6, 2009 7:31:45 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project


If you were asking whether the project will also look at influenza B, which almost exclusively infects humans, then I think so, because that virus is also covered in hemagglutinin and neuraminidase.


That's what I was talking about, thanks!
[May 6, 2009 8:47:26 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Sekerob
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Re: Welcome to the Influenza Antiviral Drug Search project

So maybe I will have to find what is wrong in my setup. I say "maybe" because if I am alone with this problem

You're not alone ;)
http://www.yoimg.com/i/e06c67ff9deb6d9319ad52d0e6d78900-.png

Fedora 10, Intel Corporation Mobile 945GM/GMS/GME, 943/940GML Express Integrated Graphics Controller (rev 03), BOINC 6.4.4

Can you check other AutoDock projects if looking good. On my laptop for all these I just get a black frame. HCC and HPF2 show properly.
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[May 6, 2009 8:51:39 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project

TBirdTheYuri,

There is a mechanism that prevents the servers from being flooded with error workunits from a computer producing error results. An aborted result counts as an error. As a result this mechanism has engaged to limit the number of results your computer can get.

The mechanism will lower your max daily limit by one for each result that is returned in error. Once you return valid results, your limit will be double until it gets back to the max limit of 80 results per day per processor.

You aborted a number of workunits so that you could get work for the new projects thus causing your daily limit to be lowered. As soon as you start returning the workunits successfully your limit will jump back up quickly.

However, I have manually reset your limit. You should be able to fill your cache now.



I think that people should not abort all of their current work units just because a new project comes along. It is counterproductive. It wastes computation and slows down WU validation for others. By switching over to just getting new WUs from the new project and finishing the ones that you have, you start on the new ones maybe a day later. If you do have very large backlogs of old WUs, maybe you should reconsider your settings if you plan on dumping them anyway.

My 2 cents.
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Sekerob
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Re: Welcome to the Influenza Antiviral Drug Search project

Be assured that knreed will do this quota resetting by exception! All this user side aborting causes many results to be recycled with short deadlines left for others with 'reliable' devices to mop them up... those that churn through the tasks in the order they arrive.
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[May 6, 2009 8:59:56 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Welcome to the Influenza Antiviral Drug Search project

sorry but I am new here
how can add this project in my boinc?
which url I nead to write?

sry for bad english, I am from Croatia
[May 7, 2009 8:52:08 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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