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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding
Thread: Which drug companies will benefit from this research? Pfizer? |
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Thread Status: Active Total posts in this thread: 13
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Just wondering if anyone knows whether the American drug companies, which are certainly in no need of charity, such as pfizer, .... and would certainly use results in order to dominate the medicine market killing competition and overcharging (all of which we are full aware of) will benefit from this research? Does anyone which companies exactly will benefit from the efforts contributed to this research project and how results will be used or controlled; including how the top 10 pharms in America will or will not benefit from results gained? Any info appreciated....
Andrew England |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
This is answered in 'Start Here' at http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=1582
The short answer is: all of them. The long answer: the results we create with our computers become public domain, like the multiplication table. All medical / biological researchers in the world can use them. Lawrence |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Minkeyman007 --
This topic has been about beaten to death in the forum thread at http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=199. In that thread, one member (Azeeb) quoted portions from the Request for Proposal document that must be submitted by organizations wishing to use the World Community Grid. It is worth restating his post here: The RFP (Request for Proposal) document clearly states: "World Community Grid is designed as a resource for research done with a philanthropic or humanitarian purpose and will only be available to projects conducted for public and not-for-profit purposes. It will serve as a useful tool for the completion of a certain stage of research, hastening the progress of projects into further phases of development. Results must be made available to the global research community by the sponsoring research organization and remain in the public domain. The results will also be available on World Community Grid’s website for volunteers and other visitors." Also: "World Community Grid, with technology and funding provided by the IBM Corporation, is making grid technology available to public and not-for-profit organizations to use in humanitarian research that might otherwise not be completed due to the high cost of the computer infrastructure required in the absence of a public grid." And: "Following the conclusion of the project, the research organization will make results produced by World Community Grid freely available to other research organizations within six months. The research organization also will provide results in a lay version for the World Community Grid community of volunteers and interested visitors to the web site." There are also other threads in the forum that discuss the not-for-profit nature of this venture. The search facility of the forum will allow you to research this. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
According to all agreements available on this site. The results of this computation are public domain. Who ever knows were to go to acccess the info can go weather academic or private industry.
Information wants to be free an oldtime internet slogan sure applies here. All results are free to all no matter what thier status. So I suppose this could be a doubleedged sword to some. I can guartee you though that any application from this computation will not be developed through the university system. Even Universitys at best would create a private spin off company to develope any applicable medical apps. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I would like you to know that Merck phar. supplied my wife 300.00 a pill nausea medicine for free. They have a program for people that cannot afford medicine!!! And if we could get the GD lawyers out of the lawsuit business all medicine would be cheaper!!!TAKE THAT
----------------------------------------[Edit 1 times, last edit by Former Member at Apr 20, 2005 11:44:38 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
EMEND® (aprepitant) Helps Prevent Nausea/Vomiting for Breast Cancer
The results of an investigational study evaluating the effect of an antiemetic regimen including EMEND® in the prevention of nausea and vomiting after chemotherapy in breast cancer patients were published today in the Journal of Clinical Oncology (JCO). Results from this study of patients who received chemotherapy treatments moderately likely to cause nausea and vomiting showed that significantly more breast cancer patients treated with the regimen including EMEND (EMEND in combination with a 5-HT3 receptor antagonist and a corticosteroid) reported a complete response in the five days after initiation of chemotherapy compared to a standard regimen (5-HT3 receptor antagonist and a corticosteroid) (50.8% vs. 42.5%, p=0.015), as measured after the first cycle of chemotherapy. Complete response is defined as no vomiting and no use of other therapies for nausea or vomiting. Additionally, significantly more patients in the group taking EMEND reported no vomiting over the five days of the study (76% vs. 59%, p <0.001). Use of other therapies for nausea and vomiting was similar between the two treatment groups (59% vs. 56%, p=ns). Also, more patients receiving EMEND reported minimal or no impact of nausea and vomiting on their daily life (63.5% vs. 55.6%, p=0.019). “Patients often report that the vomiting and nausea associated with chemotherapy is very difficult and distressing for them and their families, and breast cancer patients can be particularly vulnerable to nausea and vomiting,” said Kelly B. Pendergrass, M.D., study investigator and clinical oncologist at Kansas City Cancer Center. “In this study of breast cancer patients who received chemotherapy that is moderately likely to cause nausea and vomiting, we found that in the group of patients who received the regimen including EMEND, fewer patients experienced nausea and vomiting after chemotherapy than patients who received other common therapies used alone.” Both regimens were generally well tolerated. The most common adverse events reported with both patient groups were hair loss, fatigue, headache and constipation. This worldwide, multi-center, randomized, double-blind, parallel-group study evaluated 857 breast cancer patients who had never before undergone chemotherapy. Patients in the study received chemotherapy that is moderately likely to cause nausea and vomiting and is the most frequently used chemotherapy regimen used to treat breast cancer. The following agents were administered either alone or in combination: IV cyclophosphamide 750-1500 mg/m2 (+ 5%); IV cyclophosphamide 500-1500 mg/m2 (+ 5%) and IV doxorubicin <60 mg/m2 (+ 5%); IV cyclophosphamide 500-1500 mg/m2 (+ 5%) and IV epirubicin <100 mg/m2 (+ 5%); other chemotherapeutic agents Hesketh Level 2 or lower were allowed to be added to the above chemotherapeutic regimens. Patients were randomized to receive either the regimen including EMEND (day 1: EMEND 125 mg one hour before chemotherapy, ondansetron 8 mg 30-60 minutes before chemotherapy and dexamethasone 12 mg 30 minutes before chemotherapy followed by ondansetron 8 mg eight hours later; days 2-3: EMEND 80 mg once daily) or a standard regimen (day 1: ondansetron 8 mg 30-60 minutes before chemotherapy, dexamethasone 20 mg 30 minutes before chemotherapy and ondansetron 8 mg eight hours later; days 2-3: ondansetron 8 mg twice daily). Patients reported incidences of nausea, vomiting and use of other medications for nausea and vomiting in a diary for five days. EMEND, when added with other medicines, is currently approved in the United States to help prevent and control nausea and vomiting caused by initial and repeat courses of chemotherapy treatments that are highly likely to cause nausea and vomiting in adult patients. Important information about EMEND EMEND is not used to treat nausea and vomiting that patients already have. Patients should tell their doctor about all the medicines they are taking, if they are pregnant or plan to become pregnant, or if they have liver problems. EMEND may cause serious life-threatening reactions if used with certain medicines. Patients should not take EMEND if they are taking any of the following medicines: ORAP® (pimozide), SELDANE® (terfenadine), HISMANAL® (astemizole) or PROPULSID® (cisapride). Taking EMEND with these medicines could cause serious or life-threatening problems. EMEND may also affect some medicines, including chemotherapy, causing them to work differently in the body. Women who use birth control medicines during treatment with EMEND and for up to one month after using EMEND should also use a back-up method of contraception to avoid pregnancy. The most common side effects with EMEND are tiredness, nausea, hiccups, constipation, diarrhea, and loss of appetite. These are not all of the possible side effects of EMEND. About Merck Merck & Co., Inc. is a global research-driven pharmaceutical company dedicated to putting patients first. Established in 1891, Merck discovers, develops, manufactures and markets vaccines and medicines in more than 20 therapeutic categories. The company devotes extensive efforts to increase access to medicines through far-reaching programs that not only donate Merck medicines but help deliver them to the people who need them. Merck also publishes unbiased health information as a not-for-profit service. For more information, visit http://www.merck.com. this is the product that was donated to my wife at no charge ---------------------------------------- |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Just wondering if anyone knows whether the American drug companies, which are certainly in no need of charity, such as pfizer, .... and would certainly use results in order to dominate the medicine market killing competition and overcharging (all of which we are full aware of) will benefit from this research? Does anyone which companies exactly will benefit from the efforts contributed to this research project and how results will be used or controlled; including how the top 10 pharms in America will or will not benefit from results gained? Any info appreciated.... Andrew England Hi Andrew, I live in England, too. I spent most of last year undergoing treatment for cancer and I can understand why Marysduby, whose wife has incurable cancer, is so upset with you. Yes, American companies will benefit from this research. In fact, given the much greater amount of money that the U.S. government spends on basic medical research, I expect that the main benefits will go to firms with U.S.-based R&D (which includes many firms that you would probably consider European, like Bayer, GSK and Sanofi-Aventis). I am sure that the drugs will be expensive when they come out, but I don't care because: 1. The information we are providing is pretty basic: companies will have to put a great deal of work in to get a product to market. 2. The Human Proteome Project is more likely to increase competition than stifle it. Right now if a company finds a protein that is very important in a major disease, they can patent it in the U.S. and there is some concern that this stifles innovation by keeping competing companies from working on the same problem. 3. Whether these innovations come to market eight years from now or thirty years from now, they will still be expensive. The main beneficiaries will be the patients, who will have access to better medicines more quickly. Patents don't last forever and the sooner something makes it into clinical trials, the sooner it comes off patent in the end. 4. The big problem with the drugs companies not the prices charged, but that often they don't offer good value for money. It is hailed as a major breakthrough when a highly unpleasant drug combination offers a lousy four month increase in survival for women with breast cancer that has spread to other organs. The most recent 'breakthrough' of this type cost a mind boggling $80,000. New medicines are so inexpensive and ineffective that some U.S. cancer patients are in danger of running through the $1 million lifetime limit on their health insurance without ever being cured. There is still no cure for AIDS, MS and alot of other diseases as well, just long-term treatments. Some types of cancers don't have any treatments at all. As such, I don't worry that the drugs companies will make money out of this research. I just hope they can use it to make drugs that really work. Christine |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Dittos and kudos to Christine MH---I Pray that you recover
----------------------------------------[Edit 1 times, last edit by Former Member at Apr 25, 2005 12:05:18 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Dittos and kudos to Christine MH---I Pray that you recover Dear Marysduby, How sweet. I had primary breast cancer. No recurrence yet, but a high risk type and it's incurable if it returns. Fortunately, Genentech has just made a big advance against it. Prayers that I can figure out how in the world to get my hands on some of their medicine would be appreciated. I hope that there's some advance at ASCO that will help your wife. Best wishes, Christine |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Dittos and kudos to Christine MH---I Pray that you recover Dear Marysduby, How sweet. I had primary breast cancer. No recurrence yet, but a high risk type and it's incurable if it returns. Fortunately, Genentech has just made a big advance against it. Prayers that I can figure out how in the world to get my hands on some of their medicine would be appreciated. I hope that there's some advance at ASCO that will help your wife. Best wishes, Christine No disease is incurable. What I just said is not based on hope but Facts, fact of our existence. The required Knowledge and Technology derived from it has yet to come to being in order to destroy such Biological threats. Wish you well; Hopefully your breast cancer does not return. |
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