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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding
Thread: Does This Project Aid In Curing The Disease Of Aging? |
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Thread Status: Active Total posts in this thread: 4
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I am a member of a Non-Profit Organization which has a goal of Scientific Conquest Of The Disease Of Aging. There are Many Scientists all over the world who are involved in this Great And Noble Cause. To my knowledge, speaking to the scientists will yield more information, aging is caused by "Internal Influence" (DNA) And "External Influence" (Oxygen, Radiation, also Viruses and other living matter contribute to damage). I am hoping this project aids in dealing with the "Internal Influence" side. If we find out what genes are responsible for what, we can create a more intelligent and efficient biological structure. Better regeneration and Defence will be possible. Oxygenation, Radiation, Viral and such damages will be 100% efficiently repaired. People will be able to regenerate lost limbs, a lbind child will have the ability of sight ( All body parts simply will be able to regenerate if lost or damaged, period). There are also Cosmetic applications; Knowing all the DNA, will give us the ability to also choose how we look, that is; Eye colour, Height, Skin tone etcetera. Although this is a question I will give the Websites of some of the best individuals who are working towards such goals.
Websites Are; http://www.gen.cam.ac.uk/sens/ http://imminst.org http://www.mprize.org Post Script; Once again, Viewing the websites does this project aid in True Anti-Aging? Why I say True Anti-Aging is because Plastic surgery, Botox and so on do nothing, the cells are still dying; Those are just cosmetic procedures which do not contribute to Biological Immortality. Thank You. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I will answer this question with a qualified 'Yes'. [Please note: I am not a scientist and I may be wrong.] The internal workings of a cell (metabolism, etc.) involve many cycles with material handed off from one protein to another, sometimes being modified and sometimes not. Meanwhile, other proteins do nothing but regulate the 'working' proteins and send and receive messages. There are many different research paths to try to elucidate these cycles. One way is to study the structure of the folded protein molecule and try to figure out which other proteins it works with and what it does. This information is then stored as an annotation for that protein. We are trying to build a database predicting the structures of small proteins (<= about 150 amino acids) so that, among other things, these cycles can be figured out.
Understanding the internal cycles controlled by proteins within the cell is basic biological research that will help with understanding a number of processes, including aging, cell repair, metabolic diseases, etc. Another point to keep in mind is that most basic cycles are found in all cells, but hundreds of millions of years of mutations can produce proteins serving the same function that appear from the genetic sequence to be very different. Once they are folded, the similarity is much easier to see. So figuring out something in a yeast cell can lead to an immediate understanding of how that cycle works in human cells, if you know the structure of the proteins in the yeast cell and know the structures of human proteins. Then it becomes a matter of spotting the analogous human proteins using their structural similarity, even though the DNA templates look quite different. Hope I have not gotten it all wrong.  Lawrence |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
It is hard for me to imagine any other research that can have more of a direct and dramatic effect on understanding the "disease of aging."
 The following is an excerpt from the January, 2004 edition of their magazine published by www.LEF.org. (See archives at this URL for complete articlel.) I have been a member for over 20 years. Protein Degradation Initiated by Free Radicals Another pathway to aging involves the accumulation of proteins with toxic carbonyl groups. Carbonylation results from protein oxidation and reactions of proteins with sugars, aldehydes, and lipid peroxidation products. Protein carbonylation increases with age, damaging about one-third of the body’s proteins later in life. These dysfunctional proteins accumulate in vital organs, clogging the cellular machinery just as the buildup of sludge clogs an automobile engine until it seizes. Carbonylated proteins are visible in aging skin and cataracts. Their destructive effects on cellular function underlie diverse age-related conditions, from neurodegeneration, cardiovascular disease, and kidney failure to the chromosomal instability that leads to cancer. New research shows that as yeast cells age through succeeding cell divisions, a threshold is crossed that dramatically increases chromosomal instability, thereby increasing genetic defects by a multiple of 40 to 200.13 Chromosomal instability is a prerequisite for tumor development and increasingly is recognized as a driver of age-related degeneration. The authors of the yeast study point out that mutation rates increase with age, while the risk of developing cancer increases more than tenfold in humans from age 40 to age 70. They postulate that the accumulation of age-related damaged proteins thwarts the cell’s sensors for detecting DNA damage. Thus damaged proteins prevent cells from repairing damaged DNA or activating an orderly cell-death program. Consequently, damaged cells survive and reproduce, leading to mounting genetic, and in particular chromosomal, instability. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thanks Lawrencehardin and Julied; You both have given me greater insight when it comes to this matter, I do appreciate it.
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