If you are issuing a large amount of assets to an address, or indeed sending a large number of transactions to that address, then your problem will be the large number of UTXOs (unspent transaction outputs) which belong to that address. This can lead to slow transaction building like you see.
You can confirm if this is a problem by examining the utxocount field of the output from getwalletinfo.
The solution is to combine UTXOs, either explicitly using the combineunspent API, or else using the autocombine* runtime parameters (which are configured for sensible behavior by default). But this is only possible if the address has send as well as receive permissions.
As for these errors you are seeing in the debug log, it would be helpful for us to know what API calls were being made (if any) at the timestamps shown for those errors. And please also confirm which version of MultiChain you are using.