The structural information for the HIV-1 protease comes from a few sources.
The main source for crystal structures (i.e. structures solved by x-ray
crystallography is the Protein Data Bank (PDB). In addition to being the
worlds main repository for protein crystal structures, the PDB has a very
nice web site with excellent general background and educational material.
The site is www.rcsb.org/pdb (or type "pdb" at a search engine). While
you're there, check out the "Molecule of the Month" feature written and
illustrated by David S. Goodsell, an Associate Professor here at Scripps
and member of the Olson lab. The June 2000 edition of the Molecule of
the Month features the HIV-1 Protease.

We also have a collection of "modeled" structures of HIV-1 protease
mutants and docking to these modeled structures is an active area of
research.

Lindy