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World Community Grid Forums
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Thread: Proteome folding 75% done in 8/05? Why aren't we done yet? |
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Thread Status: Active Total posts in this thread: 7
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
According to this published article, written on August 22, 2005, the World Community Grid was, at that time, 75% completed with the human proteome folding project -- having amassed 14,000 years of computing in just 9 months. That suggests to me that about 5,000 more years of computing, or less, would finish the job; well, that was more than six months ago, and the WCG has collected another 19,000 years or so of CPU time, so why aren't we done yet? I realize that time is also being spent on AIDS research (I came here from FA@H and fully support that research here, and have my profile set to do all research), but if even just a third of that additional time were spent on folding, it ought to be done by now. Did WCG just make a mistake in its estimate of how much was done and how much more needed completion? I have no 'beef' here; I'm just curious.
Cheers. Bill Velek |
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retsof
Former Community Advisor USA Joined: Jul 31, 2005 Post Count: 6824 Status: Offline Project Badges: 
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We have finished the phase I folding for human part. They are not ready to go yet with HPF Phase II, so we then started to fold some plant material. There are some other threads on this. Aradopsis, a mustard plant, was the first addition to go under the crease. Then, there is a database of Swiss-prot proteins I think we're hitting now.
----------------------------------------The latest status update from Dr. Bonneau at http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=5626 says that we have crunched 90 genomes! Back when he was talking about Arabidopsis, he said we had crunched 80 genomes. The recent update says that we are crunching through Swiss-Prot. It is a database of annotated proteins set up back in 1986 (in Zurich then, now I believe it is hosted in the United Kingdom) when scientists had to do proteins one at a time rather than a genome at a time. So these are proteins somebody considered important. If our predicted structure for one of these proteins is very similar to anything we have crunched in our 90 genomes, then the annotated information probably applies to our protein as well. It's one way to avoid reinventing the wheel! mycrofth Instead of just refolding and refolding old data, we are doing useful scientific work. My Pentium III/500 just finished an HPF workunit --- after 8 days. There's a whole forum section above concerning the HPF project, so I will not point to any particular thread.
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----------------------------------------Work+GPU i7 8700 12threads School i7 4770 8threads Default+GPU Ryzen 7 3700X 16threads Ryzen 7 3800X 16 threads Ryzen 9 3900X 24threads Home i7 3540M 4threads50% [Edit 5 times, last edit by retsof at Mar 8, 2006 2:35:51 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thanks for the update, retsof. When I read your first paragraph, I was leaning toward changing my config to do just AIDS research, since I consider human disease more important than plant research. However, after reading the quote from mycrofth, I'll leave it like it is since the plant research will probably have indirect applications to human disease, too.
Cheers. Bill Velek |
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retsof
Former Community Advisor USA Joined: Jul 31, 2005 Post Count: 6824 Status: Offline Project Badges:
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Thanks for the update, retsof. When I read your first paragraph, I was leaning toward changing my config to do just AIDS research, since I consider human disease more important than plant research. However, after reading the quote from mycrofth, I'll leave it like it is since the plant research will probably have indirect applications to human disease, too. I let the computer power determine my usage and give them a profile to fit. My slow one can only work on HPF. More choices (plants, etc.) of proteins means that the confidence in folding ANYTHING can be increased.Cheers. Bill Velek My fast systems prefer the AIDS project because the transfer files are tiny and the computers can quickly get back to crunching. There may be some different project splits coming soon anyway. Things are running smooth here. I just crunch what I see.
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----------------------------------------Work+GPU i7 8700 12threads School i7 4770 8threads Default+GPU Ryzen 7 3700X 16threads Ryzen 7 3800X 16 threads Ryzen 9 3900X 24threads Home i7 3540M 4threads50% [Edit 1 times, last edit by retsof at Mar 8, 2006 3:42:36 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
billvelek, that's right. one day we are going to be part spinach!!
---------------------------------------- http://www.google.com/search?hl=en&q=plan...22&btnG=Google+Search [Edit 1 times, last edit by Former Member at Mar 8, 2006 7:22:51 PM] |
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retsof
Former Community Advisor USA Joined: Jul 31, 2005 Post Count: 6824 Status: Offline Project Badges:
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billvelek, that's right. one day we are going to be part spinach!! 
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Work+GPU i7 8700 12threads School i7 4770 8threads Default+GPU Ryzen 7 3700X 16threads Ryzen 7 3800X 16 threads Ryzen 9 3900X 24threads Home i7 3540M 4threads50% |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
billvelek, that's right. one day we are going to be part spinach!! |
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