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World Community Grid Forums
Category: Official Messages
Forum: News
Thread: Research update from the MCM team (September 2023) |
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Thread Status: Active Total posts in this thread: 12
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WCGAdmin
World Community Grid Admin Joined: Jun 9, 2020 Post Count: 175 Status: Offline |
The MCM team?s analysis has shown that ovarian cancer results were dishomogeneous. We will begin running additional ovarian work units starting September 25th.
https://www.worldcommunitygrid.org/about_us/article.s?articleId=802 |
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danwat1234
Advanced Cruncher Joined: Apr 18, 2020 Post Count: 56 Status: Offline Project Badges: 
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How many ovarian work units are estimated to be released? Sounds like you may benefit from additional compute after all. Could you explain further what an ideal graph would look like and why?
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Dayle Diamond
Senior Cruncher Joined: Jan 31, 2013 Post Count: 452 Status: Offline Project Badges: 
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The results were dishomogeneous.
That seems like something that would have revealed itself some time ago. What's the scope of this discovery? Are these new work units meant to clarify why the results were not expected, or to replace years of work that's already calculated? Are we running 160 billion gene signature calculations again? |
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johncmacalister2010@gmail.com
Veteran Cruncher Canada Joined: Nov 16, 2010 Post Count: 799 Status: Offline Project Badges: 
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The results were dishomogeneous. That seems like something that would have revealed itself some time ago. What's the scope of this discovery? Are these new work units meant to clarify why the results were not expected, or to replace years of work that's already calculated? Are we running 160 billion gene signature calculations again?  crunching, crunching, crunching. AMD Ryzen 5 2600 6-core Processor with Windows 11 64 Pro. AMD Ryzen 7 3700X 8-Core Processor with Windows 11 64 Pro (part time)  |
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johncmacalister2010@gmail.com
Veteran Cruncher Canada Joined: Nov 16, 2010 Post Count: 799 Status: Offline Project Badges:
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The results were dishomogeneous. That seems like something that would have revealed itself some time ago. What's the scope of this discovery? Are these new work units meant to clarify why the results were not expected, or to replace years of work that's already calculated? Are we running 160 billion gene signature calculations again? I wish I could understand this stuff…….. crunching, crunching, crunching. AMD Ryzen 5 2600 6-core Processor with Windows 11 64 Pro. AMD Ryzen 7 3700X 8-Core Processor with Windows 11 64 Pro (part time) |
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Robokapp
Senior Cruncher Joined: Feb 6, 2012 Post Count: 264 Status: Offline Project Badges: 
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the opposite of homogeneous.
basically "diverse". |
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thunder7
Senior Cruncher Netherlands Joined: Mar 6, 2013 Post Count: 238 Status: Offline Project Badges:
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The MCM team?s analysis has shown that ovarian cancer results were dishomogeneous. We will begin running additional ovarian work units starting September 25th. https://www.worldcommunitygrid.org/about_us/article.s?articleId=802 Great to read that this long-running project is going on. Will you be adding the 500 year badge soon? Perhaps 1000/2000 too? |
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TigerLily
Senior Cruncher Joined: May 26, 2023 Post Count: 280 Status: Offline Project Badges: 
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What's the scope of this discovery? Are these new work units meant to clarify why the results were not expected, or to replace years of work that's already calculated? Are we running 160 billion gene signature calculations again? The scope of the new run is to extend the number of signatures to clarify the behaviour of the already calculated results. Ovarian calculations seem to perform better with longer signatures than shorter ones, a behaviour completely opposite to what was observed in lung cancer. Due to this preference, a much lower number of signatures had been run for ovarian cancer, compared to lung. Before we decide that there is a molecular reason behind this preference, we'd rather obtain a larger number of signatures. We are not going to discard previous results, and we are not going to run as many signatures as lung cancer, but we will be constantly monitoring the signatures' behaviour to test if the pattern starts changing or solidifies. As for the specific number of work units that will be sent out, we are still in the process of building the work units and will provide an update regarding the number of work units at that point. We will also continue to provide updates as we analyze the results. [Edit 1 times, last edit by TigerLily at Sep 25, 2023 5:49:38 PM] |
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TigerLily
Senior Cruncher Joined: May 26, 2023 Post Count: 280 Status: Offline Project Badges:
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How many ovarian work units are estimated to be released? Sounds like you may benefit from additional compute after all. Could you explain further what an ideal graph would look like and why? Hi danwat1234,We are currently building the work units and will update with an exact number once they are complete. The expected graph would be closer to a normal distribution: https://en.wikipedia.org/wiki/Normal_distribution Ovarian calculations seem to perform better with longer signatures than shorter ones, a behaviour completely opposite to what was observed in lung cancer. Due to this preference, a much lower number of signatures had been run for ovarian cancer, compared to lung. Before we decide that there is a molecular reason behind this preference, we'd rather obtain a larger number of signatures. |
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Adamos86
Cruncher Greece Joined: Jun 25, 2018 Post Count: 8 Status: Offline Project Badges:
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Thanks for the explanation
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