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Halo Jones
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Animal experimentation and WCG

Hello dear crunchers and scientists.
I have an ethical question about animal testing and the WCG. Does the World Community Grid's computer simulations for medical research increase or decrease the need for animal testing? How big is the impact, if any?

I believe compounds found by WCG must be tested in vitro or/and in vivo for further research and possible drug development for a long time, but if in silico research WCG is performing significantly reduces need for lab animals, it would be a valid argument for attracting animal rights people to start crunching (and a motivational boost for everyone I guess). Some large organization like PETA writing an article and encouraging people to join WCG would be really nice.
[Apr 5, 2017 11:37:13 AM]   Link   Report threatening or abusive post: please login first  Go to top 
hiimebm
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Re: Animal experimentation and WCG

I would think that regulatory agencies would still need actual live tests. On the other hand, knowing exactly how something (compounds) works , it would reduce the dependence on animal testing.
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[Apr 5, 2017 6:32:06 PM]   Link   Report threatening or abusive post: please login first  Go to top 
KerSamson
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Re: Animal experimentation and WCG

Hi Halo Jones,
research is a (very) long process covering, in case of WCG projects, "in silico" research activities.
The initial aim of "in silico" projects is to enable and to speed-up the identification of possible "candidates" on a very wide scale as well as to better understand particular mechanisms. Such research activities would be more or less impossible - or taking decades or centuries - if based on in vitro only.
Afterwards, it remains necessary to perform further "in vitro", "ex vivo" and at the end "in vivo" research activities.
On my side, I am not sure that relying on PETA support would be a good idea since this organisation is, for my taste, too media-oriented whereas research is at first a work requiring quietness for a long period.
Cheers,
Yves
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[Apr 15, 2017 6:37:47 AM]   Link   Report threatening or abusive post: please login first  Go to top 
Halo Jones
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Re: Animal experimentation and WCG

Thank you both EBM9000 and KerSamson for your replies, I guess you are both right.

I agree, number crunching may not be actually "PETA-style", but they do promote alternative testing methods, and even fund some. http://www.peta.org/issues/animals-used-for-e...ernatives-animal-testing/

It's difficult to find facts or any estimates for actual numbers, but I'll continue searching...
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[Edit 2 times, last edit by Halo Jones at Apr 15, 2017 10:57:25 AM]
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Former Member
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Re: Animal experimentation and WCG

PETA evokes strong political reactions in people which would be extremely counterproductive.
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Halo Jones
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Re: Animal experimentation and WCG

You are right, Citizen422, it does. But certainly no one is bringing PETA here. The idea was completely the opposite.
(Everyone please feel free to replace it with your favourite organization, it was just an example of big organization promoting in silico research, any would do just fine. But that wasn't the actual topic in the first place...) So, how about the original question about animal experimentation and the WCG?
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[Edit 1 times, last edit by Halo Jones at Apr 15, 2017 2:54:47 PM]
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nasher
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Re: Animal experimentation and WCG

I would think that even if with these projects if animal testing is not able to be reduced the fact that we are providing a new ability of computers to do the data crunching that in the future less and less will need to be tested. Animal testing is always a hard one. everything we can do on the computer makes us know more about the proteins and such therefore we should be able at least in the future reduce and maybe eliminate animal testing
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KLiK
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Re: Animal experimentation and WCG

I would think that even if with these projects if animal testing is not able to be reduced the fact that we are providing a new ability of computers to do the data crunching that in the future less and less will need to be tested. Animal testing is always a hard one. everything we can do on the computer makes us know more about the proteins and such therefore we should be able at least in the future reduce and maybe eliminate animal testing

+1

But this also has to be confirmed by doctors / researchers!
cool
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widdershins
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Re: Animal experimentation and WCG

Or you could look at it the opposite way. Thanks to improvements in computer based research it is faster/cheaper/easier to identify potential compounds for further testing. So it could be argued that increased numbers of potential compounds being identified might actually increase the amount of animal testing.

Let's not get too hung up on whether it reduces animal testing or not. You could spend all day arguing the pros and cons of computer research. The bottom line is that you have a computer that is a miracle of modern technology at your disposal.

You have two choices:

a) Ignore those dead or dying from medical ailments and leave your expensive miracle of technology turned off except for when you want to watch cat videos on YouTube

or

b) Use it to try to further medical science, accepting that should your computer find a miracle cure for cancer/HIV or whatever it will almost certainly involve some animal testing at some point.

Make your choice and live with the consequences. I've made mine.
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KerSamson
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Re: Animal experimentation and WCG

The development process of a new medicine is a long and complex process. Between the identification of a possible active pharmaceutical ingredient (API) and the end of the pharmaceutical product development, there are many activities to be carried out and animal experimentation is only one of those.
Animal experimentation, if necessary, follows a lot of other investigations. Not every possible candidate will go through (until) animal experimentation.
Cheers,
Yves
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[May 15, 2017 6:58:29 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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