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World Community Grid Forums
Category: Active Research
Forum: Help Stop TB
Thread: Interesting News Articles About TB |
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Thread Status: Active Total posts in this thread: 17
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cjslman
Master Cruncher Mexico Joined: Nov 23, 2004 Post Count: 2082 Status: Offline Project Badges: 
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I'll start this thread with this article:
----------------------------------------World Tuberculosis Day: The ancient disease that still takes 4,000 lives a day http://edition.cnn.com/2016/03/24/health/worl...ay-bekker-oped/index.html CJSL Crunching for a better world... |
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SekeRob
Master Cruncher Joined: Jan 7, 2013 Post Count: 2741 Status: Offline |
Test for 16 genes if or if not resistant to the TB bacterium
http://www.sciencemag.org/news/2016/03/simple...dliest-infectious-disease |
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Rickjb
Veteran Cruncher Australia Joined: Sep 17, 2006 Post Count: 666 Status: Offline Project Badges: 
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Tuberculosis resurgency in PNG's Daru a deadly strain coined 'Ebola with wings'
Updated Fri 15 Apr 2016 at 4:31pm A deadly new strain of tuberculosis is incubating on the small island of Daru in Papua New Guinea. Five years ago, reporter Jo Chandler went to PNG to cover another TB outbreak and ended up contracting a dangerous, multi-drug-resistant strain of the disease herself. She's recovered now, but five years on the TB epidemic in PNG is getting worse and a new, even deadlier strain has emerged. The experts are calling it "Ebola with wings". Now Jo Chandler has returned to the place where she contracted the disease, to find out why the international health community is up in arms about the unfolding epidemic. --- http://www.abc.net.au/news/2016-04-15/tubercu...9;s-daru-a-deadly/7330974 This was an audio (radio) item, and you can replay it from the page at the link. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Tuberculosis surveillance and monitoring in Europe 2017:
https://ecdc.europa.eu/sites/portal/files/med...onitoring-Europe-2017.pdf |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
This project studies the mycobacterium resistance of antibiotics:
https://www.zooniverse.org/projects/mrniaboc/bash-the-bug |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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Fast Cheap Testing for Tuberculosis? Soon It May Be Possible
----------------------------------------Diagnosing TB, a major killer, can be cumbersome and inaccurate. But a new way to detect byproducts of the bacteria may change that according to scientists at George Mason University Center for Applied Proteomics and Molecular Medicine https://www.nytimes.com/2018/01/01/health/tub...=14700208&tntemail0=y  [Edit 1 times, last edit by Jim Slade at Jan 2, 2018 3:08:54 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
For the first time in almost 100 years a new vaccine against tuberculosis has proved effective in humans.
The vaccine was developed by Statens Serum Institut in Denmark. The article announcing this piece of news is not available in English yet, but for those interested Google Translate may give the gist. The abstract and full article can be found in the New England Journal of Medicine |
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AlexGV
Cruncher Russia Joined: Apr 6, 2018 Post Count: 16 Status: Offline Project Badges: 
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WHO calls for urgent action to end TB
----------------------------------------First-ever United Nations High-Level Meeting on TB provides historic opportunity - Overall, TB deaths have decreased over the past year. In 2017, there were 1.6 million deaths (including among 300 000 HIV-positive people). Since 2000, a 44% reduction in TB deaths occurred among people with HIV compared with a 29% decrease among HIV-negative people; - Globally, an estimated 10 million people developed TB in 2017. The number of new cases is falling by 2% per year, although faster reductions have occurred in Europe (5% per year) and Africa (4% per year) between 2013 and 2017; - Some countries are moving faster than others - as evidenced in Southern Africa, with annual declines (in new cases) of 4% to 8% in countries such as Lesotho, Eswatini, Namibia, South Africa, Zambia, and Zimbabwe, thanks to better TB and HIV prevention and care. In the Russian Federation, high level political commitment and intensified TB efforts have led to more rapid declines in cases (5% per year) and deaths (13% per year); - Drug-resistant TB remains a global public health crisis: In 2017, 558 000 people were estimated to have developed disease resistant to at least rifampicin – the most effective first-line TB drug. The vast majority of these people had multidrug-resistant TB (MDR-TB), that is, combined resistance to rifampicin and isoniazid (another key first-line TB medicine); - WHO estimates that a quarter of the world’s population has TB infection. http://www.who.int/news-room/detail/18-09-201...-urgent-action--to-end-tb
i7-3632QM 4C/8T, 2.2GHz (2.9GHz Turbo), 35 W;
----------------------------------------i7-3630QM 4C/8T, 2.4 GHz (3.2GHz Turbo), 45 W. [Edit 1 times, last edit by AlexGV at Sep 20, 2018 7:49:05 AM] |
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l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges:
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New compound reverses drug resistance in tuberculosis
The bacteria responsible for TB are fast evolving resistance to our antibiotics, thwarting attempts to keep the disease under control. Now, scientists have found a new compound that can boost the power of existing antibiotics and even reverse the bugs' resistance. While it can be killed off with a treatment plan of antibiotics, the bacteria won't go down without a fight. Not only do they often develop a genetic resistance to the antibiotics, but they can also band together to form biofilms, which makes it harder for the drugs to do their job. [. . . ] The team started by screening 91 compounds that contain a certain chemical structure which has been seen to prevent other kinds of bacteria from building biofilms. Of those, a compound called C10 was found to have the desired effect on the TB bacteria – although it didn't kill the bugs itself, C10 prevented them from hiding under a biofilm. In experiments, when the team paired the compound with existing antibiotics like isoniazid, the combo was enough to wipe out the infection. Better yet, with C10 around far less isoniazid was needed to kill the bacteria, and spontaneous resistance to the drug never developed. The team tested the combination of C10 and isoniazid on TB bacteria that was already resistant to isoniazid, and found that it was able to kill the bugs. "This was a totally unexpected finding," says Christina Stallings, co-senior author of the study. "We had no idea we would be able to reverse drug resistance. More at https://newatlas.com/tuberculosis-compound-reverse-drug-resistance/59566/ |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
New drug for drug resistant TB
https://www.washingtonpost.com/health/new-ant...3-fd3c65ef8f9c_story.html |
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