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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: FightAIDS@Home project update - Novemeber 2015 |
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Thread Status: Active Total posts in this thread: 22
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branjo
Master Cruncher Slovakia Joined: Jun 29, 2012 Post Count: 1892 Status: Offline Project Badges: 
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 You have it skivelitis, don´t you? Robokapp can have it as well if (s)he want one. What else do you need?Cheers  Crunching@Home since January 13 2000. Shrubbing@Home since January 5 2006  [Edit 1 times, last edit by branjo at Dec 1, 2015 9:12:08 PM] |
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ErikaT
Former World Community Grid Admin USA Joined: Apr 27, 2009 Post Count: 912 Status: Offline Project Badges: 
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but have 1 question though: We have notified Dr. Olson about your question. Please be patient in waiting for his response.- did any of this research reach to final production of any medicine in last 10y? or to be more exact, in those 9 mentioned HIV PR inhibitor drugs - was in any of those compounds used 1 from SRI/HIVE research here on WCG? thx for answer in advance, dr Olson Thank you, ErikaT |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The short answer is no -- none of the compounds identified in phase I of FAAH are currently on the market as drugs for treatment of HIV. This is, in fact, the anticipated result of our research, since we seek to find new approaches to drug design, and are not in the field of producing new drugs, per se. At best we hope to find new lead compounds and new drug target sites (which we have done). It would be up to larger entities (such as pharmaceutical companies) to take our research and use it to develop new drugs themselves -- which entails optimizing leads to make them bio-available with low or no toxicity or side effects. In addition it requires resources beyond our capabilities to run very costly clinical trials to test the efficacy and safety of the drug candidates on large human test populations.
The drug development pipeline is a long and costly one -- typically requiring many years and upward of a billions dollars. The basic research that we do, is typically not done by "big pharma" since it is "early stage" and speculative work-- with no definite product guaranteed. This is why the support of the FightAIDS@home volunteers is so important to enable new methods, approaches, and leads. Art Olson |
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges: 
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thank you, dr Olson
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Seoulpowergrid
Veteran Cruncher Joined: Apr 12, 2013 Post Count: 815 Status: Offline Project Badges: 
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thank you, dr Olson +1 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
thank you, dr Olson +1+2 |
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SekeRob
Master Cruncher Joined: Jan 7, 2013 Post Count: 2741 Status: Offline |
Always at the top of the FAH2 forum... 'update Novem
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges:
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The short answer is no -- none of the compounds identified in phase I of FAAH are currently on the market as drugs for treatment of HIV. This is, in fact, the anticipated result of our research, since we seek to find new approaches to drug design, and are not in the field of producing new drugs, per se. At best we hope to find new lead compounds and new drug target sites (which we have done). It would be up to larger entities (such as pharmaceutical companies) to take our research and use it to develop new drugs themselves -- which entails optimizing leads to make them bio-available with low or no toxicity or side effects. In addition it requires resources beyond our capabilities to run very costly clinical trials to test the efficacy and safety of the drug candidates on large human test populations. The drug development pipeline is a long and costly one -- typically requiring many years and upward of a billions dollars. The basic research that we do, is typically not done by "big pharma" since it is "early stage" and speculative work-- with no definite product guaranteed. This is why the support of the FightAIDS@home volunteers is so important to enable new methods, approaches, and leads. Art Olson One more think dr.Olson. All of us here, have a great respect for you , your science & your team. You've all done a great job identifying new potential candidates, which might end mortality of AIDS as a complication made from HIV in upcoming decades. But recently some of us have been worried about our donation of CPU power & electricity (which we both pay with our money), as some individuals in US (Martin Shkreli ) have been buying licences for HIV & other drugs to raise prices in most liberal capitalist way. Maybe I'm a little more social capitalist (though I fancy to think of myself as a liberal-democrat, which comes as a center to right-wing in Croatia, EU - actually a member of a EPP in European parlament ) which finds that getting so much funds from the ill people is just plain wrong! So may we urge you & your team, but also WCG, to include a clause not to deal with such individuals in the future when trying to develop a drug to save the World from HIV & AIDS. Or also any other research here (a plea to WCG)! Thank you, Luka |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I believe you are not understanding Dr. Olson's reply. As he said, it will take Pharmaceutical companies to take the research from his lab and develop the drugs. Which ever company manufactures the drug will hold the patent for a given number of years. Enter Mr. Shkreli. He will either buy the patent rights to the drug or buy the pharmaceutical company including all the company's patent rights. Mr. Shkreli can then do as he wishes (within regulatory rules) with those rights. None of Mr. Shkreli's actions have anything to do with the Olson lab or WCG as it happens well downstream of those institutions. Secondarily, if the research results are in the public domain, as required by WCG and agreed to by the Olson Lab, by definition, they are open and available to anyone including Mr. Shkreli.
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges:
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I believe you are not understanding Dr. Olson's reply. As he said, it will take Pharmaceutical companies to take the research from his lab and develop the drugs. Which ever company manufactures the drug will hold the patent for a given number of years. Enter Mr. Shkreli. He will either buy the patent rights to the drug or buy the pharmaceutical company including all the company's patent rights. Mr. Shkreli can then do as he wishes (within regulatory rules) with those rights. None of Mr. Shkreli's actions have anything to do with the Olson lab or WCG as it happens well downstream of those institutions. Secondarily, if the research results are in the public domain, as required by WCG and agreed to by the Olson Lab, by definition, they are open and available to anyone including Mr. Shkreli. I do understand it...but I'm also thinking few steps ahead, to stop some bad people with bad practice in that industry (when FDA will not)! after all, most of HIV is in Africa...if we make a database that would help develop a cure, then Africa should also have to afford it! Not only wealthy US citizen.  |
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