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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding - Phase 2
Thread: Suggestions for Future Organisms to Fold |
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Thread Status: Active Total posts in this thread: 27
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello dpenfoldbrown
----------------------------------------Reference: dpenfoldbrown [Dec 11, 2012 12:04:22 AM] post . Thanks for your response. It was enlightening. Again, thanks for your discussion and interest - it's definitely got me thinking. Well, the contents of your post got me thinking too. I wanted to edit my [Dec 10, 2012 1:34:50 PM] post to include the following:An argument for efforts that 'benefit the living' can be made against the arguments for efforts that would 'benefit the sick'. With research on ageing, we approach both -- and this complements the existing 'benefit for the sick' WCG projects. At the time then, little did I know that there exists an even higher level of abstraction for which your 'effects' are members. Viewed as such, with ageing as just one 'effect', it is clear to me now why HPF2's mandate does not readily accept any instance of 'effects'. I believe there is a subtle distinction that I'm trying to get at between a specific target such as aging, and a general and more spanning target such as "things important to human health," or "the nature of food crops." I know that looks a little laughable, in text, but our goal is more to be broad... If ever you folks hear me laugh on that one, that's me saying: 'You folks are doing an excellent job' !It's simply that there is a LOT to do and look at, and prioritizing is tough. Indeed, as we have this eternal dilemma on the hardware-side: so much crunching to do, so few machines to crunch with, so that whatever resource we get better be: not only the top priority, but also the most 'right' in terms of over-all direction.So, on balance, I think it wise to stay the current WCG course. ; ; andzgridPost#730 ; [Edit 1 times, last edit by Former Member at Dec 13, 2012 1:59:13 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Nope, Archaea is still definitely on the table. Just taking a bit of a rest because we have less interest from the community / less pressing desire to look at it.
I really like the idea of Archaea, though. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Brewer's yeast?
Half joking but I imagine a lot of people would crunch for better beer. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Yeast was done at the beginning, for good reason. :D
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twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2130 Status: Offline Project Badges: 
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Yeast are probably the simplest form of eukaryote - single-celled organisms with a nucleus. Bacteria and archaea don'e have a nucleus.
----------------------------------------  [Edit 1 times, last edit by twilyth at Dec 18, 2012 9:28:27 PM] |
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twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2130 Status: Offline Project Badges:
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Here's an interesting article from the Economist from a few months back on the importance of the microbiome. I wanted to find something on this Nature Communications article referenced in the Dec 8 New Scientist (DOI:10.1038/ncomms2266 - just a blurb though), but I couldn't find anything 'human readable' so I hit google.
----------------------------------------Here's a snippet. The link with heart disease is twofold: an observation in people, and an experiment on mice. The observation in people was made by Jeremy Nicholson of Imperial College, London. Dr Nicholson, who studies the links between metabolic products and disease, has shown that the amount of formic acid in someone’s urine is inversely related to his blood pressure—a risk factor for cardiac problems. The connection appears to be an effect that formic acid has on the kidneys: it acts as a signalling molecule, changing the amount of salt they absorb back into the body from blood plasma that is destined to become urine. Since the predominant source of formic acid is the gut microbiome, Dr Nicholson thinks the mix of bacteria there is a factor in heart disease. Stanley Hazen of the Cleveland Clinic in Ohio has come up with a second way that the microbiome can affect the heart. He and his colleagues worked with mice specially bred to be susceptible to hardening of the arteries. They found that killing off the microbiome in these mice, using antibiotics, significantly reduced their atherosclerosis—though why this should be so remains obscure. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
How about the newly discovered Lake Vostok bacterium?
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twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2130 Status: Offline Project Badges:
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I'd forgotten about this thread. Microbiome research has taken huge step forward with the development of a uniform protocol for future research .
----------------------------------------In a new report appearing in the March 2013 issue of The FASEB Journal, scientists take an important step toward designing a uniform protocol for microbiome research that ensures proper controls and considerations for variations among people. By doing this, future researchers should be able to better assess how what we ingest, whether drugs or food, affects our bodies. This "microbiome project" will rival the human genome project of the 90's. More at the link. |
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Jim1348
Veteran Cruncher USA Joined: Jul 13, 2009 Post Count: 1066 Status: Offline Project Badges: 
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I would love to have a GPU version of HPF2, to replace HCC. All the other protein folding projects I do (Folding@home, POEM and GPUGrid) provide for GPUs.
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Falconet
Master Cruncher Portugal Joined: Mar 9, 2009 Post Count: 3315 Status: Offline Project Badges: 
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I would love to have a GPU version of HPF2, to replace HCC. All the other protein folding projects I do (Folding@home, POEM and GPUGrid) provide for GPUs. According to the Rosetta@home scientists, the software isn't suitable for GPU's because not only it's huge, the speedup wouldn't be significant. Since HPF2 uses the same software I don't think this will happen...  - AMD Ryzen 5 1600AF 6C/12T 3.2 GHz - 85W - AMD Ryzen 5 2500U 4C/8T 2.0 GHz - 28W - AMD Ryzen 7 7730U 8C/16T 3.0 GHz |
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