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World Community Grid Forums
Category: Completed Research
Forum: Discovering Dengue Drugs - Together - Phase 2 Forum
Thread: Discovering Dengue Drugs - Together project update, November 2012 |
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Thread Status: Active Total posts in this thread: 29
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yoro42
Ace Cruncher United States Joined: Feb 19, 2011 Post Count: 8979 Status: Offline Project Badges: 
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All that is left is Patience.
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olivier3191
Senior Cruncher France Joined: Mar 4, 2005 Post Count: 239 Status: Offline Project Badges: 
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Given the ravages of Dengue, it's a pity this project appears to be stalled....  This project appears to be stalled for us (more precisely for our computers). It doesn't mean that the scientists have stopped working for it.  |
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branjo
Master Cruncher Slovakia Joined: Jun 29, 2012 Post Count: 1892 Status: Offline Project Badges:
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Good point Olivier
---------------------------------------- Crunching@Home since January 13 2000. Shrubbing@Home since January 5 2006  |
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NixChix
Veteran Cruncher United States Joined: Apr 29, 2007 Post Count: 1187 Status: Offline Project Badges:
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Well, given that exactly 3 months ago the project researchers posted that the project would be done within the next "few" months and that alpha testing of new work was commencing. There has been silence since then. How could anyone of us mere crunchers come to any other conclusion than that the project has "stalled".
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
2) As noted above, the results from Phase 1 of “Discovering Dengue Drugs – Together” have moved into Phase 2 of “Discovering Dengue Drugs – Together”. All calculations for Phase 2 should be completed within the next few months, after which we will move this project to a “completed” state and post our results to the web. Encouragingly, even at this stage our calculations have identified several new dengue protease inhibitors that have been validated with biochemical and cell culture assays in our laboratory; these leads are entering crucial pre-clinical pharmacokinetic and efficacy studies. In addition, most of these lead compounds inhibit both dengue and West Nile virus proteases. Thus, The Phase 2 project has been very valuable in helping to identify some false positive hits, thus allowing us to concentrate our resources and time on the most promising hits. All my best, Stan (11/14/12)I have been in the process of validating the Free Energy of Binding code after solving the issues that came up with - the molecular dynamics software version, the parametrization of ligands code, etc. Now, I have given 8 co-crystal's alpha-test and after they are done, I will submit the 2000 ligand GSBP calculation for the pre-run calculation shortly. I really appreciate all your help. I will also update about the paper that I am drafting currently on dengue virus and a portal that we have developed in collaboration with TACC soon. -Usha. (11/14/12) Right now, we are alpha testing some work units. If that goes perfectly, pre-run work units could be generated after alpha testing is completed. Once all of the pre-run work units are completed, type A work units would be generated and made available. Even under the best of circumstances, I would expect it to take at least two weeks before any type A work units would be available (and that's assuming everything goes flawlessly). A more likely estimate would be further out than that. Seippel (11/16/12) We have a batch of work units received at WCG, but we need to alpha test them. So they may become available in December, unless they get delayed by the end-of-the-year squeeze, or some other problem. Lawrence (11/17/120 It's been 2-1/2 months since the above postings. The 2-week estimate has long passed. Is there any news on readying the next/final batch for crunching? Did the alpha test complete sucessfully? It may well be that the recent hardware problems have had higher priority of course, but the question of the status of the end game of this project has been posed several times long before the recent site problems and had gotten no answer then. I can help thinking that things has gone awry, but I hope that something hasn't gone wrong with moving this project to reaching a successful conclusion and getting closer to a cure for this dreaded disease. Respectfully, NixChix Cheers Going on 4 months plus with out seeing the work units, and still not seeing any updates from the project itself here on the forums. Can we please get a new update on where things stand currently Thanks! |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
/me taps the microphone
Is this thing on??? |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
How could it be? The tenants did not pay the powerbill for longer going by the state of the building ;>)
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AgrFan
Senior Cruncher USA Joined: Apr 17, 2008 Post Count: 383 Status: Offline Project Badges: 
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/me taps the microphone Is this thing on??? No - the fact we haven't heard anything in a very long time is not a good thing. I fully expect this project to be officially over very soon. I would be surprised to see new work sent out given how long it's been since the last batch. That would be quite disappointing since I only need a few more days to reach Sapphire.
[Edit 9 times, last edit by AgrFan at Mar 21, 2013 11:18:29 PM] |
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homeslice
Cruncher USA Joined: Apr 27, 2007 Post Count: 12 Status: Offline Project Badges: 
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The fact that we haven't heard anything in a very long time might mean that they are busy using the data generated thus far to work towards a cure.
----------------------------------------Which is a good thing, not a bad thing. The work units we process unfortunately don't directly give the researchers an answer. They generally identify areas to explore that might be more promising than others. This then hopefully can lead to some lab tests. Give the scientists some leniency. Publishing papers and writing updates are a necessary evil to keep people interested and generate funding, but the truth is that time spent writing is time lost in the lab. I work in research, and the rate of progress can be glacial. Feel good that what we are doing is shortening the process considerably, but it by no means makes it immediate.  |
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