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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding - Phase 2
Thread: What is the difference between HPF2 and Rosetta? [RESOLVED] |
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Thread Status: Active Total posts in this thread: 15
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The Topic really asks the whole question, but now I'm curious, having been running Rosetta under BOINC for some time.
----------------------------------------Is there any connection between these projects, in terms of the science they are doing? What overlap (if any) is there? I'm a mere layman, and would appreciate some simple insight into this one, especially as I hate duplicating work, re-inventing wheels, and so on. [Edit 2 times, last edit by Former Member at Oct 11, 2010 6:50:55 PM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The Rosetta project develops 'rosetta'
HPF 'uses' the developed software in anger.... |
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
That probably behoves translation for us foreigners who are not in with English idiom.
----------------------------------------HPF2 is production and uses the application to actually generate a principle protein folding knowledge database to include non-human species to discover commonalities. R@H is constantly improving the predictive skills, but you cant apply that in production as else you get a inhomogeneous database of results for the experiment. Currently the scientists are working on a new big one to launch, the Human Microbiome Project. Here a search link for posts by the pcw216 of HPF2. http://www.worldcommunitygrid.org/forums/wcg/...=0&sort=1&rows=20 . Not read that HPF2 will be getting a version update when this experiment commences. More from Bonneau labs here: http://homepages.nyu.edu/~rb133/wcg/rbonneau_posts.html#2010
WCG
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Richard Mitnick
Veteran Cruncher USA Joined: Feb 28, 2007 Post Count: 583 Status: Offline Project Badges: 
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Rosetta does more than develop its software. here is their statement:
----------------------------------------"Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit." |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Leaving personalities aside and returning to my original post, I was wondering more about the science of these projects - in other words, is there any point in my running both?
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
Since these guys (Bonneau of HPF2 and Baker of Rosetta) are "close", there wont be duplication of effort if that's a concern. Ignoring that blurp from the Rosetta website, in my first reply to the project website, there is this link explaining more on the differentiation http://homepages.nyu.edu/~rb133/wcg/thread_3921.html in excerpt:
----------------------------------------Conversely, our project, HPF on the WCG, aims to use stable versions of Rosetta to make predictions that can be presented to biologists and biomedical researchers in comprehensive databases with intuitive front ends. HPF on the WCG can be thought of as the production phase of the project, where we produce function annotation for many genomes and then distribute this product to biologists. Due to the large number of proteins we're folding (comprehension is essential) we need a great deal of computer time if we want to make our databases comprehensive and available to biologists.
WCG
Please help to make the Forums an enjoyable experience for All! |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you, that's very clear!
Since these guys (Bonneau of HPF2 and Baker of Rosetta) are "close", there wont be duplication of effort if that's a concern. Ignoring that blurp from the Rosetta website, in my first reply to the project website, there is this link explaining more on the differentiation http://homepages.nyu.edu/~rb133/wcg/thread_3921.html in excerpt: Conversely, our project, HPF on the WCG, aims to use stable versions of Rosetta to make predictions that can be presented to biologists and biomedical researchers in comprehensive databases with intuitive front ends. HPF on the WCG can be thought of as the production phase of the project, where we produce function annotation for many genomes and then distribute this product to biologists. Due to the large number of proteins we're folding (comprehension is essential) we need a great deal of computer time if we want to make our databases comprehensive and available to biologists. |
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
OK, could you plz open your Opening post in edit and insert just as I did for this post, insert [RESOLVED] in the title. Then support knows it needs no further attention.
----------------------------------------Thanks for crunching at WCG.
WCG
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
OK, so Movieman's second reply got deleted quietly yet again?
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TKH
Former World Community Grid Admin USA Joined: Aug 13, 2005 Post Count: 775 Status: Offline Project Badges: 
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Dear Members,
As you know we do not allow intolerance and personal attacks in our forums. You have plenty of other avenues for these types of discussions. We appreciate all our members and thank you all for your dedication to advancing science to help humanity. Tedi |
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