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Concanavalin A, contructs NCI-1, can against all kinds of type A influenza (H1N1 & H5N1 included). It has successfully been applied to many type A influ patients to treat and to protect in Asia. Belowed are some literatures for reference:

Concanavalin A in NCI-1 to Anti-Type A Influenza
Activation of influenza-specific memory cytotoxic T lymphocytes by Concanavalin A stimulation
Maya Tsotsiashvilli, Raphael Levi, Ruth Arnon and Gideon Berke*
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Received 20 July 1997; revised 23 September 1997; accepted 25 September 1997.
Available online 21 May 1998.
Abstract
Traditionally, the in vitro activation of virus-specific memory cytotoxic T lymphocytes (CTLs) has been achieved by stimulating the CTLs with antigen-presenting cells (APCs) infected with an appropriate virus or pulsed with virus-specific antigenic peptides. Here, we describe the utilization of the polyclonal activator Concanavalin A (Con A) for in vitro restimulation of memory CTLs from virus-primed mice. Using this simple method, the activation of splenocytes with Con A for 3 days (i) eliminates the need to stimulate with virus-pulsed APCs and (ii) generates CD8+ CTLs that exhibit virus specificity and MHC-restricted lytic activity similar to CTLs obtained by conventional viral restimulation. In vitro Con A stimulation of splenocytes from BALB/c mice primed with the A/Texas/77 or A/Japanese/57 strain of influenza virus and from C57L/J mice infected with the A/Texas strain, generated CTLs with specific lytic activity. Hence reactivation of memory CTLs by this method is a general phenomenon rather than a mouse or viral strain-specific one. The Con A stimulation method used here had a recall of long-term (1 year) memory CTLs that effectively lysed virally infected targets. Further Con A-stimulated effector lymphocytes from virally primed animals have been shown to recognize and subsequently lyse target cells pulsed with virus or virus-derived peptides. The Con A reactivation of specific anti-viral CTLs may facilitate (i) studying anti-viral CTL responses and (ii) identifying of viral epitopes when unknown or when appropriate viral stimulation is impossible.
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Concanavlin A in NCI-1 to Anti-Type A Influenza
Nature 288, 164 - 165 (13 November 1980); doi:10.1038/288164a0
Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line
LIN YUN LU & BRIGITTE A. ASKONAS*
National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
*To whom correspondences should be addressed.
Spleen cytotoxic T cells killing influenza virus-infected target cells are cross-reactive for the different type A influenza viruses, in contrast to the circulating antibodies, which show fine specificity for each A virus subtype variant1,2. This finding has raised the question of whether a single T cell can recognize cells infected with all the type A viruses. T-killer cell lines with specificity for alloantigens and the male Y antigen can be selected by means of growth factors present in the supernatant of T cells stimulated with Concanavalin A (refs 3−7). We report here that we have been able to establish clones of mouse T cells killing target cells infected with influenza virus. Our cell line maintains the same specificity as the heterogeneous spleen cell population from infected mice, in as far as the T-killer cells are specific for A influenza virus, but do not discriminate between the different type A viruses. The cell line maintains H−2 restriction and does not kill cells infected with B influenza virus. The cells grow in the presence of T-cell growth factor and do not require antigen for growth although they maintain their receptors for type A virus. They can also be stimulated by irradiated T-helper cells from mice primed by type A influenza infection in the presence of type A virus-infected cells.

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