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Possible Examples of Cures through Knowledge of Protein Folding

Here's why its important.

Many diseases are either cured or corrected by knowledge of proteins 3D shapes. Actually i would go as far as almost all drugs work through proteins.

(The second example most closely resembles the project aims but done via other methods.)

They work but a whole variety of ways examples:-

Old drugs:- Asprin its been round donkey's years and wasn't found by this method but some dude chewing bark of a tree.. but the reason for its ability to stop pain is protein based. Asprin is actually disables proteins for its action. stopping what naturally happens in the body. It permanantly disables Cycloxgenase(COX) and hence stop pain by a complex process. The body is amazing as aspirin only disables COX and doesn't disable other proteins which would kill you. This is done by Very shape of aspirin and how it fits only in COX proteins. This shape is precisely what we are trying to find out.

Newer reasearch which has use the newer method of reverse engineering the cure from the protein causing the disease.

Example New AIDs drug basded on GP-41 Protein.

AIDs Big disease!duh. after spending huge sums of money on it, scientist have determined the binding protein of the Virus. If you stop it from binding to cells then you stop it spreading. Simple logic not to so simple in practice.

Well they figured out the protein, sequenced it and found 3d shape. (NOT THE SAME METHOD HERE, they did not use the genome sequence). But the same aim of finding the shape. They figured out the 3D shape of it and started to make a drug to trick the virus to bind to it rather than the cell. Simply said not so easily done. but they figured it.

and now they have a drug which is protein based (a flaw since it need to be injected plus high chance of reaction) but never mind that yet. through finding the 3d shape of the human protein, they have found another target to combat AIDs. (PS this drug is not out yet, was in phase 4 clinical trials last i looked)

But the main thing whether you are a computer geek (me included) or a scientist (i'm that too) or a normal member, its about finding solutions which in turn help people.

They are nice enough to not make YOU sit in a Lab.. treasure that.. seriously.. there is nothing more boring than sitting in a white room and watch a experiement which generally takes forever and never actually work.

I thank you for the chance to contribute with this but i do have question on whether the resources are allocated most efficiently. Apart from that, i'm pretty happy with the project.

(I posted some questions in another thread)
[Feb 25, 2005 3:35:30 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Possible Examples of Cures through Knowledge of Protein Folding

Oh i forgot to answer on important question which many people seem to have..

They ask where is the cure to the disease or feed back??

Well a normal drug takes 10-15 years before available to the public (if it ever gets there 9/10 never make it). So If the project does find something useful. Expect it to be hospitals in 10-15 years time :)

Not trying to be funny but seriously, if you know the amount of work it takes then you wouldn't laughing and the best we can hope for is good leads to future cures and hope you have helped by shortening the time required to search for targets.
[Feb 25, 2005 3:46:50 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Possible Examples of Cures through Knowledge of Protein Folding

Oh i forgot to answer on important question which many people seem to have..

They ask where is the cure to the disease or feed back??

Well a normal drug takes 10-15 years before available to the public (if it ever gets there 9/10 never make it). So If the project does find something useful. Expect it to be hospitals in 10-15 years time :)

Not trying to be funny but seriously, if you know the amount of work it takes then you wouldn't laughing and the best we can hope for is good leads to future cures and hope you have helped by shortening the time required to search for targets.

I think these medicines that are developed are not the correct action for eliminating deseases--they treat the affect not the cause I think there are many things contributing to these problems as in the food we eat the way its processed-additives-hormones added to promote growth--nutrients taken out of the ground--i have noticed different tastes in foods over the years. Its like in tree growth they force trees to grow faster .If they dont produce or mature in about 20 years they abandon that part of forrest and sell it off-- old growth trees dont rot like like this new process of forced feeding-- its the same with us we eat fertilized food that i beleive do not have the nutrients they had years ago --I personally think we are looking in the wrong direction. find out what is causing all these mutations and we will find the answer not to say that these medicines arent a good thing they are but i think there is a simple answer that we are overlooking
[Mar 16, 2005 3:12:22 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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