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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: Sulfathiazole role in fighting AIDS? |
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Thread Status: Active Total posts in this thread: 4
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Evil Homer
Cruncher Joined: Oct 30, 2006 Post Count: 1 Status: Offline |
I recently had work unit "faah3197_Sulfathiazole_MIN_xMut_md09550_02" and recognised sulfathiazole as one of the sulfonamide group of antibacterials which disrupt folate synthesis in bacteria. But since humans don't synthesise folate, I would be interested to know the relevance of this to AIDS research. Is it anything to do with the hypesensitivity reactions these drugs are known to produce, such as Stevens-Johnson syndrome?
Thanks in advance |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
No. FightAIDS@Home screens millions of drug-like molecules. This is just one of many.
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GIBA
Ace Cruncher Joined: Apr 25, 2005 Post Count: 5374 Status: Offline |
Hey Evil,
----------------------------------------I think that you make a important observation. This drug besides others have strong effects and reactions in Humans. Despite of AIDS be more dangerous that this effects and reactions, I think that we can get some help to clarify your question, if some FA@H scientists will post more information here. Maybe Dr. Alex Perryman can help more (he is one of this scientists of FA@H that sametimes participates in this fora).  Regards. Giba.
Cheers ! GIB@
 Join BRASIL - BRAZIL@GRID team and be very happy ! http://www.worldcommunitygrid.org/team/viewTeamInfo.do?teamId=DF99KT5DN1 |
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mgl_ALPerryman
FightAIDS@Home, GO Fight Against Malaria and OpenZika Scientist USA Joined: Aug 25, 2007 Post Count: 283 Status: Offline Project Badges: 
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Hi Evil Homer,
Good eye! I selected "sulfathiazole," because it was one of the available fragments in SYBYL 7.2's library of fragments. I chose it as a simple chemical probe, which I am using to characterize the potential allosteric inhibitor site on the sides of HIV protease. I picked many different fragments, I modified many of them by adding different chemical groups to the same region of each fragment, and I am now testing how well each series of fragments performs. These are very preliminary studies. I am just trying to see which fragments might be able to bind weakly to that potential allosteric site, and I am trying to find out which types of modifications tend to increase the binding affinities of these test fragments within our computational models. Thanks for your help and your interest, Dr. Alex L. Perryman |
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