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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: Project completion |
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Thread Status: Active Total posts in this thread: 14
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Umm.... that doesn't actually say anything at all about how long the project will last. The current prediction is that FightAIDS@Home will have work at least until the end of 2008. Beyond that, my crystal ball is hazy. The current prediction is correct but way too conservative. Read the entire paper I cited. These researchers are bellowing "Full Speed Ahead!!!" FAAH is not going to end anytime soon, certainly not within the next 5 years. I think that was a more of a prediction by Scripps regarding in silico experiments in general (not just FAAH), but hopefully FAAH will continue for quite a while. |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: 
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Umm.... that doesn't actually say anything at all about how long the project will last. The current prediction is that FightAIDS@Home will have work at least until the end of 2008. Beyond that, my crystal ball is hazy. The current prediction is correct but way too conservative. Read the entire paper I cited. These researchers are bellowing "Full Speed Ahead!!!" FAAH is not going to end anytime soon, certainly not within the next 5 years. I think that was a more of a prediction by Scripps regarding in silico experiments in general (not just FAAH), but hopefully FAAH will continue for quite a while. Nope; again, read the entire paper! Here's another relevant quote (from the paper's abstract): "[Our work so far has enabled us to find] an AutoDock binding energy “significance” threshold of -7.0 kcal/mol between significant, strongly binding ligands and other weak/nonspecific binding energies. This threshold captures nearly 98% of known inhibitor interactions while rejecting more than 95% of suspected noninhibitor interactions. These methods should be of general use in virtual screening projects and will be used to improve further FightAIDS@Home experiments." Simplified entire-paper translation: 1) We are just now (Feb 2007) getting to the point where we really understand how to use this distributed computing stuff to attack HIV  , &2) Even though FAAH computing power is rising, our appetite for it is rising much faster  , &3) Now that we better understand what to do, FAAH is about to get medieval on HIV's ass!!!  |
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
Correct me if I'm wrong, but the algorithms know how to handle target threshold energies and move on to the next step when it is convinced it cannot reach them. Observe the actual processes and Best Energy graph C carefully which in UD client is much more visual than in BOINC graphics.
----------------------------------------As you will see in today's announcement of the FA@H update release, quorum is reduced to 2 i.e. initial distribution is 2 and only if that fails would a 3rd and subsequent be send to find matching second result. It indicates the improvement and better understanding of the process.
WCG
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Papa3, FAAH would definitely like to run and run forever, or until HIV is eradicated at least. However, the comment is their paper is about in silico experiments in general, and in silico docking in particular - not about the future of FAAH.
All we know at this point is that FAAH has firm plans to run until the end of 2008 - experiments planned, work on the way. This time next year, they may have planned more. It depends on the results they get (and the funding, of course). Or, to put it another way: FAAH have arranged with WCG enough work to last until the end of 2008. There is nothing stopping them arranging more, and I hope they do. |
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