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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding - Phase 2
Thread: Atomically-precise protein folding software developed! aids nanotechnology! Comprehensive model is first to map protein folding at atomic level |
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Thread Status: Active Total posts in this thread: 4
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Scientists at Harvard University have developed a computer model that, for the first time, can fully map and predict how small proteins fold into three-dimensional, biologically active shapes. The work could help researchers better understand the abnormal protein aggregation underlying some devastating diseases, as well as how natural proteins evolved and how proteins recognize correct biochemical partners within living cells. http://www.physorg.com/news82056528.html
----------------------------------------Since Atomically-precise protein folding software has been developed should it be adopted by the hpf poject? at least in fase 3 if it wiil continue? u can read the news here http://www.physorg.com/news82056528.html http://www.foresight.org/nanodot/?p=2363 bonus link longevity test http://www.mylonglife.com/lifespan.htm [Edit 6 times, last edit by Former Member at Nov 17, 2006 1:39:35 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Here is the first response from Folding@Home: http://forum.folding-community.org/ftopic16807.html
The press release leaves out a lot of the details in the paper. The program uses a very simplified model. We will have to see how it does at structure prediction. I think that we have a 1995 press release in our old threads that announces the solution of the protein folding problem. Lawrence |
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
The key in the original press release is "small protein". Suppose some reactions will come from the Rosetta scientists as well where a thread was opened. Possibly Dr. R.Bonneau could comment here from the HPF2 perspective, which is a high resolution computation.
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WCG
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Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
Here's the word from Dr. Baker aka Mr. Rosetta:
----------------------------------------Message 31281 - Posted 17 Nov 2006 3:51:16 UTC I gave a seminar at Harvard today, and had a chance to talk with my friend Eugene Shakhnovich, the senior author on the paper discussed in this thread. I haven't read or even seen the paper myself, but he told me he was embarrassed about all the media attention which he said was way overblown. Universities have press offices which can hype up papers much more than the scientists feel they deserve, and often considerable accuracy is lost in the process (I don't know in this case as I haven't read the paper or the press release, but I have certainly seen this in the past).
WCG
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