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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding - Phase 2
Thread: HPF1 update from baker lab |
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Thread Status: Active Total posts in this thread: 4
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I'm working tonight on a manuscript with my former graduate student Rich Bonneau on some of the results from HPF1 done on the world community grid. We predicted structures for all the proteins in one of the best studied eukaryotic organisms--the yeast used to make bread and beer, and then integrated these predictions with other experimental data to assign 500 proteins of previously unknown structure to protein structural families. After this is done, we will start working on the report on the structures of human proteins also done in HPF1. These efforts used the low resolution version of rosetta (which is all we had several years ago when the HPF project started); I am of course excited about HPF2 which is using the protocol we have been improving on rosetta@home (I sent Rich and the collaborators at IBM the code last March) and should produce much more accurate models.
http://boinc.bakerlab.org/rosetta/forum_thread.php?id=1177#24241 Have A Nice Day All........... |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Just to clarify: the above is a direct quotation of David Baker.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Here is another report on the HPF1 paper by David Baker at Rosetta@home: http://boinc.bakerlab.org/rosetta/forum_thread.php?id=1177#34088
In another news, I just put the final touches on the paper describing the first round of results from the rosetta WCG project led by my former graduate student Richard Bonneau who is now a professor at NYU. This paper is going to be published in a very successful relatively new journal called Public Library of Science, which is based on the premise that all research results should be freely available to everybody, and hence there are no subscription fees; anybody can freely look at all the papers they publish. I'll put up the link to the paper as soon as it appears so you can see how this works. |
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depriens
Senior Cruncher The Netherlands Joined: Jul 29, 2005 Post Count: 350 Status: Offline Project Badges: 
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That's very good, hopefully rbonneau will also post a small explanation over here!
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