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Former Member
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Re: About Proteome Folding

Here is an article about . . . the nucleolus in the cell nucleus that produces the ribosomes that are the protein factories in the cell. Plus it discusses the organization of the chromosomes and ways of expressing or inhibiting genes on a chromosome. It starts out above my level and eventually loses me in a daze - - but it has a lot of basic information that I did not know or only knew partially.

So here it is:
13 Dec 2006 Science Daily 'Regulating The Nuclear Architecture Of The Cell': http://www.sciencedaily.com/releases/2006/12/061211090818.htm
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Re: the MoDel project

Here is an interesting Spanish project (Phase 1 of MoDel) that took 57 years of computer time running on a 200-processor supercomputer. I don't know the speed of the processors, but my guess is that the WCG could run the same computations in less than a week, even using a quorum of 3.

10 Jan 2007 Science Daily 'Spanish Scientists Reveal Dynamic Map Of Proteins, Possibilities For New Drugs' : http://www.sciencedaily.com/releases/2007/01/070109142024.htm
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Re: the MoDel project

SDSC Triples Speed Of Blue Gene Supercomputer:
http://www.hpcwire.com/hpc/1160700.html

Scientist David Baker of the University of Washington can run his Rosetta protein structure prediction code on the Blue Gene system to design proteins more complex than previously possible, opening the way for new life-giving drugs.


Tiny Laboratory Enables Huge Leaps in Mapping Protein Function:
http://www.hhmi.org/news/quake20070112.html
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Re: About Protein Folding

one thing that might help is making the work units terminate themselves after a certain time
That is what the 1-week time limit (for some projects) is supposed to do. I don't know anyone who has actually let a stuck unit reach the time limit to see if that part of the code actually works.
Lawrence Post on: Nov 19, 2006 9:29:39 PM

Here is one "No Reply" (edited) with an error also:
10000485-10000888_ --Valid 01/30/2007 15:27 01/30/2007 16:43 0.88 12.3 / 12.3
10000485-10000888_ --Valid 01/23/2007 15:34 01/23/2007 20:41 1.42 12.6 / 12.3
10000485-10000888_ --Error 01/23/2007 15:26 01/23/2007 15:31 0.00 0.0 / 0.0
10000485-10000888_ --No Reply 01/23/2007 15:26 01/30/2007 15:26 0.00 0.0 / 0.0
10000485-10000888_ --Valid 01/23/2007 15:25 01/24/2007 05:25 0.91 12.0 / 12.3
I was using 5.4.11, I'm second in the list, a valid smile I agree that a quary from the server (or an auto report from client) should be done about mid way thru the seven day time period for activity. If no activity then resend to someone else or email then resend or whatever. This can then be made a point charge against the machine, recorded, and reviewed. After so many bad points an auto-email with questions to offender. The KISS principle can be used.
Huh?
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Sekerob
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Re: About Protein Folding

PT, by coincidence was reading that one of the security philosophies is, to have all communications be initiated by the client to a known address. No unsolicited incoming messages are wanted. That makes the system substantially weaker.

Querying mid way the 7 day period and send it to another machine, if started or not, would lead to unwanted duplication of crunching effort in a number of scenarios. I certainly would switch off WCG if after 3.5 days an email comes in to remind me when BOINC should be managing it in a 'set-and-forget'. With a multi project set up, the client might be ready to start it on day five. 7 days is 7 days.

The 1 week time limit is actually 7x24 hours CPU time of processing the WU. If started on day 6 and than crunch for 4 days, it could still come back before copy 4 returns send out at 8:01:01 after the first set of 3. The WU's are programmed to self terminate as stated after 148 hours of CPU time. The UD agent WU's do that after 3 calendar weeks wallclock accumulation or 296 CPU hours.

Statistically > 90 percent returns within 4 days from sending out. Relatively few do not return within 7 days and that on the 200,000+ we do a day at present. It would still be quite a few KISSed emails. They could irritate to no end, particular as i can see that part time crunchers (very probably not interested in the points either) would get more than their fair share of these messages.

Just a 2 cent opinion :D
(if anything included u already knew, my fault :>)
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Re: About Protein Folding

Here is an article from Rice University titled 'Structural Biology Breakthrough: New Way To Analyze Moving Parts Of Large Proteins' dated 2 May 2007 in Science Daily: http://www.sciencedaily.com/releases/2007/04/070430181143.htm

And another article about a discovery linking Alzheimer's Disease and Parkinson's Disease with several other degenerative disorders: http://www.sciencedaily.com/upi/index.php?fee...1392900-bc-us-amyloid.xml
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[Edit 1 times, last edit by Former Member at May 2, 2007 6:16:08 PM]
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Re: About Protein Folding

Hey Ya
Cheers Lawrence Hardin and Sekerob. I'm an Aircraft Mechanic, out of work albeit, but the mechanical analogies are great. And my education, and thirst for more knowledge, has only been enhanced by participation in this project. So much so, that I'm going to finish my last year, finally, of college, at age 50!!!
Please also, continue to send stuff out here that is so far over my head, I am forced by curiosity to do my own research. It gets me away from being lazy,and if we are challenged, we will overcome the obstacles!! cool rose good luck
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Re: About Protein Folding

Aloha
Hey Sekerob
C//:D: to you too...
!!! cool rose good luck
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Diana G.
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Re: About Protein Folding

Hey Ya
Cheers Lawrence Hardin and Sekerob. I'm an Aircraft Mechanic, out of work albeit, but the mechanical analogies are great. And my education, and thirst for more knowledge, has only been enhanced by participation in this project. So much so, that I'm going to finish my last year, finally, of college, at age 50!!!
Please also, continue to send stuff out here that is so far over my head, I am forced by curiosity to do my own research. It gets me away from being lazy,and if we are challenged, we will overcome the obstacles!! cool rose good luck


Hi 7cures! Praise God! That is some awesome news about you graduating this year!!! Way to go! cool

Hugs!!

Diana G.
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Re: About Protein Folding

That's awesome 7cures - congrats! applause
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