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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: RNAi Therapy for all diseases |
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Thread Status: Active Total posts in this thread: 7
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Ok this is Block Buster News .There has been a new therapy for all diseases called RNAi .Im wandering how this is linked to the World Community Grid .as this is genomic research also .Evidently they only lack a delivery method for alot of diseases . GEO
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Been said before...I have mentioned RNA Interference(RNAi) myself. It's a lost cause for the most part for now. Even the best scientists have probably barely or never heard of it much less your local doctor.
1998 was probably the first I heard of RNAi yet a doctor wouldn't have a clue or even most scientists as work is still in pre-embyronic stages of understanding. A simple good search will pull up all there is to know in seconds. I believe the mechanism called "dicer" could be useful in helping to eliminating HIV from the body in combination with multiple drugs to achieve this affect. Some would serve as markers to flag the target foriegn RNA for destruction. Here is a nice animination with a women speaking if you just like to cut to the chase and know what RNAi is about in a nut shell: http://www.nature.com/focus/rnai/animations/index.html Here is a nov 7th 2005 link from Science Daily http://www.sciencedaily.com/releases/2005/11/051106180933.htm January 2006 http://www.physorg.com/news9868.html http://www.brightsurf.com/news/headlines/view.article.php?ArticleID=22569 http://www.wi.mit.edu/news/archives/2006/cpa_0505.html |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Perhaps not a lost cause after all...
May 25th 2006 http://www.sciencedaily.com/releases/2006/05/060525120239.htm |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Great news! Thanks for the update, Rbolo!
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
These are very exciting drugs. Before I realized that I couldn't stomach killing rats anymore, I was doing research on another kind of gene-inhibiting drug caled pNA, or peptide-nucleic acid - it was one of the hopefuls for an antisense drug (for genetic disorders, not for retroviruses), but solubility and delivery issues make it very difficult.
As was mentioned above, the biggest problems with these drugs are their size. RNAi that is ten nucleic acid bases in length will be approximately ten times the size of an average drug. Increased size means that it is even more difficult to either dissolve them, or to get them into the cells once they are dissolved. In a glass dish RNAi seems to work pretty well. In an animal, it's really tough to get them to the afflicted tissue let alone into the afflicted cells. Hopefully someone will come up with a solution to this problem! |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi Travis,
Why not use a virus as a vector? |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi Travis, Why not use a virus as a vector? Viruses can, and are currently used to deliver interfering sequences -- do a quick search on "lenti virus" and "RNAi" and see what comes up. |
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