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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Common cold is a virus and there is no cure for it. How can we say that they can find a cure for AIDS ? No way.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
As for the common cold, looking up Rhinovirus ( http://en.wikipedia.org/wiki/Rhinovirus ) I find:
There are over 105 serologic virus types that cause cold symptoms, and rhinoviruses are responsible for approximately 50% of all cases. ....... There are no vaccines against this virus as there is little-to-no cross-protection between serotypes. Pneumonia is another catch-all term referring to 70+ viral and bacterial diseases. If we only had 1 cold virus to contend with, we might have major research projects underway trying to beat it. But with 105 different diseases, all called the same thing, we are waiting for the technology to improve. Almost nobody would pay much for a cure that left us vulnerable to 104 other types of colds. But people are willing to pay for a cure to HIV. Lawrence |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I like how some people refer to such things as being so simple when infact the universe we know is actually very complex and no generalizations can sufficient account for all the properties.
I found this in the following link from the cdc: "Both HA and NA regions encompassed a sufficient number of polymorphic sites to define subtypes." http://www.cdc.gov/ncidod/eid/vol12no04/05-1441.htm I decypher from the following article that the Influenza virus(flu) is a polymorphic virus. I suspect evolution has made these viruses become very smart at outsmart our immune system as it only recognizes the last viral signature or antigen. It can take days to produce the proper and correct antibodies to a new virus. I don't have a degree in this line of stuff but I do know we severly under estimate the evolution process and adaptation of viruses. I believe new viral strains are created every year of the flu which we try to adapt vaccinations against the 13 most major ones but don't always succeed in covering all the new strains and we might be causing them to adapt faster also by doing so. In short, I think we have alot to learn before making dumb assumptions. Viruses might always be the thorn in our side which we may never completely get rid of them as they are the great equalizer or balancing force in nature. Look at Mumps...1,100 new cases just popped up...in people who were injected with the MMR vaccinations. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
It all points to what I have already stated. There can not be a cure for HIV / AIDS. Virus can not be treated. May be it can be controlled if the particular strain is benevolent to human beings and allows it to be controlled.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I think there can be a way. No one really tries much for the cold virus, because quite frankly, it's not all that deadly and we've lived with it for thousands of years (i think). There's a cure for everything, the question is just whether or not it's attainable within a reasonable period of time.
----------------------------------------If we do find the cure for HIV, it's most likely a drug which targets a very essential viral protein in a certain way. Specifically, it'd inhibit the protein in such a way that in order to gain resistance to the drug, the virus would have to mutate the protein to a nonfunctional version of the protein. Thus, if it the virus doesn't get mutations to protect itself from the drug, it'll "die", but if it does get mutations, the protein can't function any longer and it'll still "die." If you do some reading, this seems to be what happens with a certain enzyme called lysin. Bacteriophages (viruses which infect bacteria) use this enzyme to break up the bacteria's cell wall in order to escape and spread. When they tested this class enzymes as an antibiotic in the laboratory, they got no detectable bacteria which could survive treatment with the enzyme. What probably happened was that the bacteriophages, over millions of years, evolved an enzyme which both killed the bacteria and is difficult to adapt to. If there's a mutation in the target of this enzyme, the bacteria dies because of how vital the target is. If it doesn't adapt to it, the enzyme kills it. Getting kinda long, i know =P If that doesn't turn out to be the case, I personally think using modified viruses to modify our DNA will be capable of curing MANY diseases. This might be in the somewhat distant future, though, since there doesn't seem to be much interest in this field atm. But when it does get developed, there could probably be some way where you can literally just delete or overwrite any viral DNA which got introduced, and voila, virus is gone. of course, it's not as easy as i made it seem, but i think this method has a lot of potential. [Edit 1 times, last edit by Former Member at Apr 28, 2006 2:11:50 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I am currently going for school for electronic engineering and get to take a fair amount of calculus. I suspect on a chemical level that drugs would need to be designed to cover a certain amount of "derivatives" or mutations the virus could modify into as a safety measure to ensure effective drugs and minimal dosage requirements.
I don't even want to think about the mathematical nightmare involved but I suspect once they derived the right formulas then we might have the right recipe to destroy viruses on a large, consistent, predictable scale. Might not even know what I'm talking about tho...just an idea I had while reading the last post that we would never defeat a virus or cure it. I think it's really about being smarter in the end and taking into account everything that can occur. Maybe, drugs could be designed to have certain amount of derivatives themselves to prevent resistance? ** Most everything in the universe tries to seek the lowest stable point and be in balance. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
V.S.S.SARMA, smallpox is a virus - a particularly nasty one, as I'm sure you know.
We have eradicated smallpox. Completely. With enough effort, we can do the same for any disease. The reason we don't attempt a cure for the common cold is because doing so would be prohibitively expensive, and a cold merely causes mild discomfort. Palliative medicine works out much cheaper. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Well, excellent point Didactylos. But then how was smallpox treated ? Did Edward Jenner use a drug to cure it ? No way. He tried variolation which subsequently became vaccination. WHO decided that the virus should be eradicated in 1967 and by 1971, lo, it was gone from the face of the earth. The point is, if they had been trying to eradicate smallpox with drugs, the work would still be going on and smallpox would have killed many millions of people. There is a need to learn from this cure to bring about the eradication of the HIV virus. All the drug cures that they are finding will take many many years of research and funding but will not eradicate the disease.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
You seem to be taking an entirely negative view. Vaccination would be an important part of any eradication program. Unfortunately, HIV works in a very different way to smallpox, and currently there is no vaccine. It seems likely that a live or attenuated vaccine will never work, although a synthetic vaccine is a vague possibility. Of course, if there were a vaccine, (or even the possibility of one) then you would be entirely correct.
But the work we are doing here is entirely new. Why predict failure without understanding what is being done? At the very, very, worst, we will rule out a large number of possible drugs, allowing research and funding to be diverted to other avenues of HIV research. (A minor correction: smallpox was eradicated by 1979, not 1971.) |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Didactylos: Are there any viral diseases which are cured by drug therapy ?
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