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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding
Thread: How does this project different from Folding@Home? |
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Thread Status: Active Total posts in this thread: 14
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Folding@Home is trying to simulate critical folding processes to learn how to approximate them with less laborious computational methods. Everybody else is using easier methods, though less accurate. Read the articles in ABOUT at http://boinc.bakerlab.org/rosetta/ for more detailed information. In particular, HPF is actually folding proteins to produce a database of predicted structures.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you!
Although I don't understand......  |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Well, each project is different. We are trying to fold proteins without known structures and we are storing the predicted structures in a database. So far we have done this for 90 genomes +. Folding@Home is studying proteins with a known structure, trying to find an algorithm that will allow them to fold the proteins into their known structure.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Oh, I understand now.
Thanks!!!  |
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bigmike
Cruncher Joined: Nov 14, 2005 Post Count: 1 Status: Offline |
Well, each project is different. We are trying to fold proteins without known structures and we are storing the predicted structures in a database. So far we have done this for 90 genomes +. Folding@Home is studying proteins with a known structure, trying to find an algorithm that will allow them to fold the proteins into their known structure. Thank you. That's the most concise description of the difference that I've read. Any chance you can make this thread sticky? |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
From Wikipedia.org
Recent developments in the protein folding world by both David Baker's research group at the University of Washington and Rama Ranganathan's research group at the University of Texas Southwestern Medical Center have demonstrated that the folding of proteins, as well as protein-protein interactions and protein engineering can be best solved using principles of cooperative evolutionary conservation. This is not the approach taken by Folding@home, which has rendered it somewhat obsolete. This recent work is tied to the Rosetta@Home distributed computing protein modeling effort. My English is not good..... So is Folding@home obsolete? confused http://en.wikipedia.org/wiki/Folding%40home |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I would not consider the Folding@Home approach to be obsolete. It is a very computationally intensive method that offers a chance to REALLY understand how proteins fold. But for the moment it is more pragmatic to use simpler, less accurate methods when actually folding proteins computationally. Rosetta is a good 'rule of thumb' program for folding proteins, while GROMACS tries to show scientists what actually happens during folding.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank You Very Much for your explanation.
It is clear! |
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Victor A. Wedge
Cruncher Joined: Mar 7, 2006 Post Count: 1 Status: Offline Project Badges: 
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Well, each project is different. We are trying to fold proteins without known structures and we are storing the predicted structures in a database. So far we have done this for 90 genomes +. Folding@Home is studying proteins with a known structure, trying to find an algorithm that will allow them to fold the proteins into their known structure. At first, I thought this answered a question I came here with. But on closer examination I'm not so sure. I saw the application 'rosetta 4.22' running under WCG and decided to detatch from rosetta@home as long as I was attached to WCG. I was unaware of folding@home until now. I have very limited crunching horsepower, but I'm thinking this: attach to folding@home while remaining attached to WCG (which will include rosetta@home's mission) ... or am I totally off the mark about rosetta@home? |
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