excuse for not answering this fndemntl question earlier:

good question ... i thought i had put that up... in any case i detail this in the proposal i sent to IBM and remembering writing that I mistakenly thought i had comunicated it all via the forum.

actual answer:

2 seperate biomedical focuses of hpf2 :
1) malaria + human secreted proteins AND
2) cancer biomarkers

The second phase (HPF2) would take important proteins with interesting novel predictions from HPF1 and refine those predicted structures (with something we call all-atom mode) to a higher level of resolution/accuracy (HPF1 == fold resolution, broad fold-function survey; HPF2 == higher res for more detailed conclusions). I’ll talk more about this next month.
We will focus in this second stage on malaria and human proteins that are predicted to be secreted proteins. These proteins are central to our understanding of Host-Pathogen interaction. We will also go after cancer biomarkers (proteins that are over-expressed in tissues or tumors of cancer patients) identified as part of several ongoing studies at the ISB.

is this the correct amount of detail?

There are many out there that are foaming at the mouth to get some cancer stuff to work on --- since it has affected so many family members directly.

Great news!!

Thanks a lot Dr. Bonneau for this update. Yes, that is sufficient detail. I am predicting that there might be an HPF3 and HPF4 , since cancer and malaria are only two diseases out of many.