I see no problem, Linux queries the environment during boot and adapts so unless you’ve moved part of the disk space to another drive then it will run quite happily.

I have Kubuntu 20.04 running on a Ryzen 9 3900X.
Works like a charm for WCG. In parallel I operate GPUGrid for the Nvidia 2070S on the same machine.

I have not been able to get any wireless to work with Linux, so all my Linux machines are wired, at least to a hub which is wired to a wireless range extender. It is my understanding that the wireless protocols are proprietary so are not built into most Linux distributions. I seem to remember Sekerob posting about a Linux distro which had the wireless drivers integrated in to the distro, but I can not find it at the moment. If I do, I will post a link if I do.
Cheers

Same here. Ubuntu worked fine on 18.xx with a USB WiFi adapter. On 20.xx none of them work unless I install a new WiFi card on the Motherboard. Unfortunately, most of my Linux machines are USFF devices too small for a card. So I had to search through the parts closet and install a switch & cat6 patch cables to get them to connect. I thought I was done with Ethernet cables!!!

I have loaded every driver package I could find on "Ask Ubuntu" and nothing has worked except installing a new WiFi card and loading its proprietary driver. I hope this gets fixed in the next distro.

My linksys AE1000 wifi usb stick works on both systems. The linksys AC1200 doesn't work on either version 18 or 20 Ubuntu.