I am doing the same thought process, but am a little further along on what I have. In short, the GPU projects are getting rather thin. Folding is nice (I have two Maxwell and four Pascal cards on it), but they haven't upgraded their software for awhile and I am going to wait until they come out with Core 22 before pushing on to the next generation cards, probably late this year or sometime next year. I think you can afford to wait in other words for the Volta, and get the benefits of it on the new core.

I currently think that CPU projects are more interesting for a variety of sciences, both biomedical research, physics and astronomy if you are interested. I just finished a Ryzen 1700 build myself (Ubuntu 17.10), and will be building a Ryzen 2700 next year. I always give them six months after introduction to get the bugs out, or at least identify them, which saved me the "segfault" errors on the 1700, not to mention the memory compatibility problems. But the 2700 is just a die shrink, so such caution may not be quite so necessary. Good luck.

PS - If you need another biomedical CPU project, the great Rosetta is the one to get. Dr. Baker will undoubtedly be receiving a Nobel Prize before long; it is just a matter of when, not if.
https://www.nytimes.com/2017/12/26/science/protein-design-david-baker.html?_r=0
However, as I have posted on their forum, my Ryzen does not do so well on it in terms of output or errors. I use my Ivy Bridge chips instead, with Ubuntu 16.04, and save the Ryzen for here, where it does great.

The problem with GPUGrid (I have done it a lot) is that they don't always have work. They can keep your GPU busy for several months, and then very little for months more. Folding always has work, but you do need to install its own software. I use both Folding on the GPU and BOINC for CPU work on all my machines (five Ubuntu and one Windows).

I think you mean CPU to my knowledge they do not a GPU client I believe there software does not one on GPU's

Why is that? Liquid cooling would likely prolong the life of the card, and keep it cooler so you could probably overclock. But the expense of modifying an existing card (assuming it isn't liquid cooled stock) with an expensive water block, and adding a radiator seems like a lot of expense.

I am not particularly a fan of OEM design cards that just blow hot air back around in the case, but they seem to work fine for gamers. Granted, that is not the same as 24/7 computing. I much prefer the blower style of Founders Edition cards for compute. This design pulls air from inside the case, across the heatsink, and out the back of the computer. The cards can be stacked next to each other, and won't overheat like OEM design will. We have machines with up to 4 and 8 reference design cards at work for compute purposes, and with proper case flow, the cards don't even get close to thermal throttling.