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World Community Grid Forums
Category: Support
Forum: Suggestions / Feedback
Thread: Project idea: imputation |
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Thread Status: Active Total posts in this thread: 17
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello Impute,
First, let me say that your tenacity is admirable, however your efforts here are largely misdirected. The primary audience of the World Community Grid Forum is the group of computer owners who contribute computer time to the Grid, and indirectly, to researchers. Your efforts would best be directed toward identifying researchers or research organizations that share your specific goals, requesting that they consider making a proposal to WCG to create a project. You need to be prepared for the eventuality that they are unable to respond to you in a meaningful way. Professsionals of this level of expertise are a surprisingly small group, but they are also well networked, so you should also ask if they know of research organizations that more nearly match your goals. I seem to detect in your forum entries a certain level of desperation. If that is valid, I wish to sympathize, and encourage you to channel that urgency more in the direction I have suggested. Best wishes. Paul |
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twilyth
Master Cruncher US Joined: Mar 30, 2007 Post Count: 2129 Status: Offline Project Badges: 
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Impute: As others have said, you need to contact researchers directly. You would be surprised at how responsive they can be if you approach them the right way.
----------------------------------------I would try to contact someone at a local University in their molecular biology department and tell them of your interest and ask them to put you in touch with someone there who is familiar with this field of research. Then talk to that person and explain what you have in mind - a distributed computing project that would use the power of WCG to analyze publicly available genomes (at least I think that's what you're saying). That person should have some idea of who in the field of research would a) have an interest in such a project and b) have the staff capable of both coding the necessary application as well as structuring the data for distribution and analyzing the results. All WCG does is handle the basic mechanics of distribution, retrieval and reporting. The actual science is pretty much a black box to both us and the staff. Of course the staff has a better idea of what to look for in terms of results being returned but even they aren't familiar with the science involved in the projects. You need to think of WCG as something akin to the post office. We accept letter and packages, process and deliver them but we don't really look very closely at the contents.   |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you very much for your replies.
It is quite true that I have become exasperated at the responses that I have received here and elsewhere about the imputation idea. However, at least here people have been very cordial. Yes, I do agree that finding a research organization to make the proposal to the World Community Grid would be the best way to go. The problem is that the people who currently do not have access to genome imputation are the many 100,000s who have genotype results. These people do not strictly fall under the domain of any research organization. The idea is to allow people who have their own genotype files to submit these results and have them imputed. Typical gene chips report 1 million SNPs. Imputation would yield 35 million more high quality SNPs, though this requires substantial computing resources. The rules of the WGS specifically require project applicants to be research organizations. I thought that there might be some variance given in this instance. This would be a project where people could help people without a research intermediary. The epsilon 4/4 carriers who will almost certainly late onset Alzheimer dementia expressed considerable interest in this idea. I will try and find some research organization that would be willing to help them. |
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KLiK
Master Cruncher Croatia Joined: Nov 13, 2006 Post Count: 3108 Status: Offline Project Badges: 
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The programs for genome imputation have been written and are freely available. For example, Impute2 and Beagle. There already is an overwhelming scientific demand for imputation. There have been over 10,000 GWAS published. However, there is no large scale distributed computing program that is currently devoted to this task. The WCG could provide the computing power to help the scientists running the imputations. In addition, scientists must now have the technical know how to run the programs, a WCG project would simplify the task for them. If the WCG provided this service, then there would almost certainly be an overwhelming demand from the scientific community. The proposal could be written on behalf of the scientific organizations that would demand the service. WCG would & could provide the servers that can send out the data for crunching... but first things first: 1. scientist must apply to WCG 2. scientist from University MUST COMPLY with WCG regulations (many of the scientist were rejected by WCG) 3. scientist must send DATA |
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noderaser
Senior Cruncher United States Joined: Jun 6, 2006 Post Count: 297 Status: Offline Project Badges: 
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If you can't come up with a plan that fits the rules for WCG, you can always create your own BOINC project. After all, it is open source software--but that would require a bit more work on your part.
----------------------------------------Unless you find some researchers who are interested in the results, you're probably going to have to take it upon yourself. It sounds a bit like you're trying to get everyone else to do the work for you. ---------------------------------------- [Edit 1 times, last edit by noderaser at Jun 10, 2014 3:46:39 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Of course we actually place more credence on the views of members who also contribute to WCG
 http://www.worldcommunitygrid.org/stat/viewCo...alue=&firstLoad=false |
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JmBoullier
Former Community Advisor Normandy - France Joined: Jan 26, 2007 Post Count: 3715 Status: Offline Project Badges: 
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It sounds a bit like you're trying to get everyone else to do the work for you. Never delay to tomorrow what could have been done yesterday by somebody else.  |
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