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World Community Grid Forums
Category: Community
Forum: Chat Room
Thread: MERS (Middle East respiratory syndrome) VIRUS |
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Thread Status: Active Total posts in this thread: 12
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
It's recently in the news. A deadly virus.
Is there anything WCG can do to help find a vaccine? |
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PecosRiverM
Veteran Cruncher The Great State of Texas Joined: Apr 27, 2007 Post Count: 1053 Status: Offline Project Badges: 
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I think that's something to ask the researcher's.
----------------------------------------We're here when they need our help.    |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I have been struggling with my new Windows 8.1 computer. I am finally getting the upper hand but I have not been doing any deep searches on the news. The MERS coronavirus seems new. It will have to be crystallized before xray diffraction analysis can create a computer model for in silico testing. I have not checked, but I doubt anybody hasa proper computer model yet.
 Lawrence |
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cjslman
Master Cruncher Mexico Joined: Nov 23, 2004 Post Count: 2082 Status: Offline Project Badges: 
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It will have to be crystallized before xray diffraction analysis can create a computer model for in silico testing. No idea what that means (no compliant on you're part Lawrence, it just means I have to go Google it  ). Anyway... that is what we are here for... MERS, SARS, etc. These should be the diseases that the WCG crunches in the future. I'm ready, bring it on !!!  CJSL Gotta keep crunching, there's a world to save !!! PS: "in silico": is an expression used to mean "performed on computer or via computer simulation." (I'm getting there... slowly but surely) |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
These should be the diseases that the WCG crunches in the future. WCG crunch what they are given, not what they or we want! It is the researchers outside of WCG who provide! |
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cjslman
Master Cruncher Mexico Joined: Nov 23, 2004 Post Count: 2082 Status: Offline Project Badges:
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Yeah, Alan, I know that... I guess it was my subconscious that was expressing it's wishful thinking
----------------------------------------.CJSL Crunching for a better future... |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Yes, I also wish to see more projects to help.
MERS has been described as a deadlier cousin of SARS, with as high as 30% fatality. SARS has been around for some time now, but still no vaccine or computing projects either. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi cjslman and jr1,
----------------------------------------My apologies for being unintelligible in my last post. Naturally WCG has to wait for scientists to propose a project but often there is a more important reason why diseases are not being investigated on computers. Molecules are all curled up so that only a surface is presented for chemicals to attack. This surface has to be mapped by X-ray diffraction analysis. There are a lot of potential problems that techniques are slowly being developed to overcome. For example, shortly after we began FAAH in 2005 (maybe in 2007?) improvements revealed an 'allosteric' site which we spent years finding several drug candidates to work against. This was more than a decade after first mapping the target molecule, so that shows how much we need to improve our technology. Before xraying a molecule, it has to be crystallized out of liquid suspension. This is a lengthy process that sometimes succeeds and sometimes fails. The HCC project we worked on was an attempt to develop a high throughput crystallization technique using computer vision. I think that it was Target #10 for HFCC that we waited a year for before giving up. It just would not crystallize. Our computers are helpless against molecules that refuse to crystallize. Crystallizing molecules is more rule-of-thumb kitchen cooking than high-tech button pushing. Sorry for not being clearer before, Lawrence [Edit 1 times, last edit by Former Member at May 19, 2014 7:34:26 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Talking molecules or protein/virus/pathogen needing to be crystallized? We know the success had at hfcc in getting their previous new target prepared, and the news read a women getting 10 million doses of measles inoculant and being cured of myeloma http://www.usatoday.com/story/news/nation-now...ncer-mayo-clinic/9115363/. How they figured that out to try this is amazing. How many years of research went before to get to this idea?
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cjslman
Master Cruncher Mexico Joined: Nov 23, 2004 Post Count: 2082 Status: Offline Project Badges:
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Lawrence... thank you so very much for your detailed explanation. It helped a lot to understand the process.
----------------------------------------CJSL Gotta keep crunching, there's a world to save !!! |
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