PS--Although phase 1 of GO Fight Against Malaria is ending, our other World Community Grid project "FightAIDS@Home" is still going strong. We also started collaborating with many other prominent experts on HIV, as part of a newly-created Center called the "HIVE". See: http://fightaidsathome.scripps.edu/ and http://hive.scripps.edu/ . In fact, we will soon expand the FightAIDS@Home project and start targeting three different allosteric sites on HIV reverse transcriptase that were recently discovered and three different allosteric sites of HIV integrase that were also recently discovered. In addition, we will soon add the ability to perform docking calculations with the software "AutoDock Vina" on FightAIDS@Home, which will enable us to increase the speed and scale of our virtual screens against these three drug targets from HIV/AIDS by several orders of magnitude.

Please keep helping our other World Community Grid project by checking and/or changing your preferences to make sure that you can contribute calculations to advance FightAIDS@Home.

Thank you all very much for your help and generous support!

Best wishes,
Alex L. Perryman, Ph.D.

we will switch to Vina for a while on FAAH, since it is not only faster but also more accurate against at least one of the allosteric sites on HIV reverse transcriptase. We plan to switch back and forth between Vina and AutoDock on FAAH, depending on which docking program is more accurate in positive control calculations against the particular site of the particular drug target against which we are screening compounds.

Thank you very much for your interest and your support!

Cheers,
Alex L. Perryman, Ph.D.